Autoimmune Thyroid Disease in Rheumatoid Arthritis: A Global Perspective

Roldán, Jorge Cárdenas; Amaya-Amaya, Jenny; Hoz, Juan Castellanos-de la; Giraldo-Villamil, J.; Montoya-Ortiz, Gladys; Cruz‐Tapias, Paola; Rojas-Villarraga, Adriana; Mantilla, Rubén D.; Anaya, Juan Manuel

doi:10.1155/2012/864907

Cited by 78 publications

(83 citation statements)

References 103 publications

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“…The prevalence of thyroid disorders noted in a Colombian cohort of RA patients was 9.8% (mean age 51.92, n=800) with higher levels of thyroid antibodies (28 (29). Moreover, the prevalence was higher in patients with early RA (6-24 months).…”

Section: N Discussion and Conclusionmentioning

confidence: 89%

Comorbidities and related factors in rheumatoid arthritis patients of south India- Karnataka Rheumatoid Arthritis Comorbidity (KRAC) study

Chandrashekara

Shobha

Dharmanand³

et al. 2017

Reumatismo

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SUMMARYThe aim was to study the prevalence of comorbidities in rheumatoid arthritis (RA) patients in everyday clinical practice and their association with disease-specific and demographic factors. The multi-center study recruited 3,247 (at 14 centers, and 265) were excluded due to incomplete data. The number of subjects considered for the analysis was 2982. The mean (±standard deviation) age was 48.98±12.64 years and the male-to-female ratio was 1:5. The data was collected based on a pre-structured pro forma by trained clinical research associates through interview and verification of charts and reports available in the patient records. The following comorbidities were studied: cardiovascular disease, hypertension, diabetes mellitus, hypercholesterolemia, thyroid disease, psychiatric diseases like depression, and pulmonary disease. Hypertension (20.7%), diabetes mellitus (14.4%) and thyroid disease (18.3%) were the most prevalent comorbidities. Hypercholesterolemia (5.3%), pulmonary diseases (2.1%), cardiovascular diseases (0.2%) and depression (0.03%) were prevalent in ≤5% of the study population. The overall presence of comorbidity increased with age and reduced with the duration of illness prior (DOIP). The age, gender, and DOIP differed significantly between groups with and without hypercholesterolemia. Females had a statistically increased prevalence of thyroid disease. The prevalence of comorbidities in RA patients from south India is around 40% and the incidence of comorbidity increased with age. As per the literature evidence, the prevalence in the current study subjects was higher when compared to prevalence of similar diseases occurring in the general south Indian population.

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Section: N Discussion and Conclusionmentioning

confidence: 89%

Comorbidities and related factors in rheumatoid arthritis patients of south India- Karnataka Rheumatoid Arthritis Comorbidity (KRAC) study

Chandrashekara

Shobha

Dharmanand³

et al. 2017

Reumatismo

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“…The number of patients with hypothyroidism and hyperthyroidism were 4.3%. A literature review disclosed a geographical variation of thyroid disease in RA ranging from 0.5% to 27% [31].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D, inflammatory markers, steroid use and systemic factors: which is the culprit in rheumatoid arthritis associated osteoporosis?

Saad

AbulSaad²,

Ali³

2016

Int Arch Med

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Aim: To explore the risk factors for osteoporosis in Rheumatoid Arthritis (RA) patients. Methods:A cross-sectional study was conducted on 93 patients meeting the American College of Rheumatology -European League Against Rheumatism classification criteria for RA 2010(ACR-EULAR). Serum 25-OH vitamin D (25(OH) D levels was measured. In addition, the levels of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), rheumatoid factor (RhF), anticyclic -citrullinated protein/peptide antibodies (Anti-CCP) were assessed. Dual-energy X-ray absorptiometry (DEXA) was also used to measure the bone mineral density BMD of the left femur at the time of recruitment. Results:The RA cohort was predominantly female (88.2%). The average age of the participants was 46.5 ± 15.2 years. Osteoporosis was present in 25 (26.9%). Osteoporotic cases were significantly older (p <0.001), female (p = 0.032) and had significantly more frequencies of diabetes (p = 0.022) and hypertension (p = 0.018) and had significantly lower calcium (p = 0.038). Logistic regression model for factors affecting osteoporosis showed that Steroids intake, increasing age and decreasing serum calcium were factors increasing the likelihood of having osteoporosis. Vitamin D did not show any relation with osteoporosis. Serum inflammatory markers like ESR, CRP, R.F and anti-CCP were higher in osteoporotic group but not significant. Conclusions:The results of this analysis indicated that systemic factors like age and intake of steroids are culprit factors in rheumatoid arthritis associated osteoporosis.

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“…При наличии у пациента аТПО и/или аТГ и нор-мальном гормональном статусе говорят только об «им-мунологических нарушениях», хотя такие больные ос-таются в группе риска развития АЗЩЖ в дальнейшем [27,28].…”

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“…Частота АЗЩЖ при РА в разных странах колеблется от 0,5 до 27%, еще чаще у больных РА наблюдается продук-ция органоспецифических аутоантител: аТПО (5-38%), аТГ (6-31%) [28][29][30][31][32].…”

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