Autoimmune thyroid disease and other non-endocrine autoimmune diseases

Todorović-Dilas, L; Ičin, Tijana; Novakovic-Paro, Jovanka; Bajkin, Ivana

doi:10.2298/mpns1104183t

Cited by 18 publications

(10 citation statements)

References 28 publications

(16 reference statements)

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“…Overall, 35–40% of patients with autoimmune thyroid diseases have atrophic gastritis [26], while 33% of patients with primary hypothyroidism have been shown to have antibodies to gastric parietal cells, and 12% have pernicious anemia. Intrinsic factor antibodies have also been observed in patients with autoimmune hypothyroidism [9].…”

Section: Discussionmentioning

confidence: 99%

“…Many autoimmune diseases, such as pernicious anemia, myasthenia gravis, idiopathic hypoparathyroidism, vitiligo, celiac disease, type 1 diabetes mellitus, autoimmune liver diseases, primary biliary cirrhosis, multiple sclerosis, Addison’s disease, rheumatoid arthritis, and systemic lupus erythematosus, may accompany HT [9]. Vitamin B12 (vit-B12) deficiency has been reported frequently in autoimmune thyroid patients [10].…”

Section: Introductionmentioning

confidence: 99%

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Vitamin B12 and Vitamin D Levels in Patients with Autoimmune Hypothyroidism and Their Correlation with Anti-Thyroid Peroxidase Antibodies

Aktaş

2019

Med Princ Pract

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Background: This study was designed to investigate the vitamin D (vit-D) and vitamin B12 (vit-B12) levels and their correlation with anti-thyroid peroxidase (anti-TPO) antibodies in patients with autoimmune hypothyroidism. Methods: A total of 130 patients diagnosed with autoimmune hypothyroidism were included in the study retrospectively. The patients were divided into two groups as those having vit-B12 levels below 200 pg/mL (n = 60) and vit-B12 levels equal to or above 200 pg/mL (n = 70). These two groups were compared in terms of age, sex, thyroid-stimulating hormone (TSH), free-T4 (FT4), vit-D, and anti-TPO. The correlation between vit-B12 and anti-TPO levels was also investigated in these groups. Patients were then divided into four groups according to their vit-D levels. Patients with normal vit-D levels (25[OH]D >30 ng/mL; n = 5), those with vit-D insufficiency (20–30 mg/mL; n = 9), those with vit-D deficiency (10–20 ng/mL; n = 43), and those with severe vit-D deficiency (<10 ng/mL; n = 73). These four groups were compared in terms of age, gender, TSH, FT4, vit-B12, and anti-TPO levels. In addition, the correlation between levels of vit-D and anti-TPO was also investigated. Results: We found that vit-B12 deficiency and vit-D deficiency were associated with autoimmune hypothyroidism, and that there was a negative correlation between vit-B12 and vit-D levels and anti-TPO antibodies in these patients. Conclusion: In patients with autoimmune hypothyroidism, vit-D and vit-B12 deficiency should be investigated at the time of diagnosis and periodically on follow-ups.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vitamin B12 and Vitamin D Levels in Patients with Autoimmune Hypothyroidism and Their Correlation with Anti-Thyroid Peroxidase Antibodies

Aktaş

2019

Med Princ Pract

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“…It is suspected to be an autoimmune disease, having a genetic predisposition and being influenced by environmental and ethnic factors. [23]…”

Section: Introductionmentioning

confidence: 99%

Thyroid disorders associated with alopecia areata in Egyptian patients

et al. 2014

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Context:Alopecia areata (AA) is a common form of localized, non-scarring hair loss. The etiopathogenesis of the disease is still unclear, but the role of autoimmunity is strongly suggested. AA is commonly associated with various autoimmune disorders; the most frequent among them is autoimmune thyroid disorders.Aim:To determine whether AA is associated with thyroid autoimmunity or thyroid function abnormalities in Egyptian patients.Materials and Methods:Fifty subjects with AA (37 males and 13 females) without clinical evidence of thyroid disorders were selected from Dermatology Outpatient Clinic, Menoufiya University Hospital, Menoufiya Governorate, Egypt, during the period from June 2009 to February 2010. They were divided into 3 groups according to severity of AA. Fifty age and sex-matched healthy volunteers (35 males and 15 females) were selected as a control group. Every case and control were subjected to history taking, complete general and dermatological examination. Venous blood samples were taken from cases and controls after taking their consents for measurement of thyroid stimulating hormone (TSH), free T3, freeT4 and detection of Anti-thyroglobulin Antibody (Tg-Ab) and Anti-thyroid Peroxidase Antibody (TPO-Ab).Results:Subclinical hypothyroidism was detected in 16% of cases. There were statistically significant differences between cases and controls regarding levels of TSH, free T3 and free T4. There were significant differences between cases and controls regarding the presence of Tg-Ab and TPO-Ab.Conclusions:Every patient with AA should be screened for thyroid functions and presence of thyroid autoantibodies even in absence of clinical manifestations suggestive of thyroid affection.

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“…Although the pathogenesis of AA is still not completely understood, genetic, environmental and autoimmune factors are considered to play, most possibly, a role in its etiology. AA is a T cell-mediated organ-specific autoimmune disease (4)(5)(6). AA is associated with various autoimmune disorders such as vitiligo, atopy, Hashimoto's thyroiditis, diabetes mellitus, psoriasis, celiac disease, and lupus erythematosus (1,3,7,8).…”

Section: Introductionmentioning

confidence: 99%

Thyroid Dysfunction in Alopecia Areata

Saniee¹,

Zare²,

Radmehr³

2019

Turk J Endocrinol Metab

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Objective: Alopecia areata is commonly associated with autoimmune disorders such as thyroid dysfunction. This paper aims to evaluate thyroid dysfunction in alopecia areata patients among the Iranian population. Material and Methods: In this case-control study, 80 alopecia areata patients were recruited along with 122 age and sex-matched healthy subjects; serum thyroid stimulating hormone and anti-thyroid peroxidase levels were then compared between the groups. Results: All alopecia areata patients had similar rate of increased thyroid stimulating hormone (10% vs. 8.2%, p=0.66) and anti-tiroid peroksidaz levels (15.6% vs. 23.8%, p=0.14) as compared to the controls. Patients with disease duration >6 months had significantly higher anti-tiroid peroksidaz levels (42.9% vs. 16.9%, p=0.01), with no difference in thyroid stimulating hormone levels (19% vs. 6.8%, p=0.1). Female patients also had higher abnormal anti-tiroid peroksidaz levels (35% vs. 12.5%, p=0.01) compared to the males. Conclusion: Thyroid stimulating hormone and thyroid antibodies are not significantly increased in alopecia areata patients when compared to the normal population. Thyroid antibodies, however, were found to be increased in females and with the progression of disease duration. Therefore, thyroid function and antibodies must be evaluated in alopecia areata patients, especially in females, and along different time periods in individuals having the disease for a long time.

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Autoimmune thyroid disease and other non-endocrine autoimmune diseases

Cited by 18 publications

References 28 publications

Vitamin B12 and Vitamin D Levels in Patients with Autoimmune Hypothyroidism and Their Correlation with Anti-Thyroid Peroxidase Antibodies

Vitamin B12 and Vitamin D Levels in Patients with Autoimmune Hypothyroidism and Their Correlation with Anti-Thyroid Peroxidase Antibodies

Thyroid disorders associated with alopecia areata in Egyptian patients

Thyroid Dysfunction in Alopecia Areata

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