Autoimmune skin disease among dermatology outpatients in Botswana: a retrospective review

Madu, Pamela; Williams, Victoria; Noe, Megan H.; Omech, Bernard; Kovarik, Carrie L.; Wanat, Karolyn A.

doi:10.1111/ijd.14201

Cited by 17 publications

(29 citation statements)

References 21 publications

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“…Nevertheless, the classically cited prevalence approximates 0.1%-0.3% in a general hospital setting 14, 15, and LS is therefore recognized as a rare condition by the Genetic and Rare Diseases Information Center (GARD) of the National Institutes of Health (NIH) and the National Organization for Rare Disorders (NORD) 4, 5. Most recently, a report on the prevalence of LS in Botswana amassed to 0.2%, falling within this range 16. In contrast, however, the European Dermatology Forum classified LS as a common disease 17 and the prevalence of LS was observed to be 1.67% in a general gynecology clinic in the United States 18.…”

Section: Epidemiologymentioning

confidence: 99%

Lichen Sclerosus: An autoimmunopathogenic and genomic enigma with emerging genetic and immune targets

Tran¹,

Tan²,

Macri³

et al. 2019

Int. J. Biol. Sci.

108

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Lichen sclerosus (LS) is an inflammatory dermatosis with a predilection for anogenital skin. Developing lesions lead to vulvar pain and sexual dysfunction, with a significant loss of structural anatomical architecture, sclerosis, and increased risk of malignancy. Onset may occur at any age in both sexes, but typically affects more females than males, presenting in a bimodal fashion among pre-pubertal children and middle-aged adults. A definitive cure remains elusive as the exact pathogenesis of LS remains unknown. A general review of LS, histologic challenges, along with amounting support for LS as an autoimmune disease with preference for a T h 1 immune response against a genetic background is summarized. In addition to the classically referenced ECM1 (extracellular matrix protein 1), a following discussion of other immune and genetic targets more recently implicated as causative or accelerant agents of disease, particularly miR-155, downstream targets of ECM1, galectin-7, p53, and epigenetic modifications to CDKN2A, are addressed from the viewpoint of their involvement in three different, but interconnected aspects of LS pathology. Collectively, these emerging targets serve not only as inherently potential therapeutic targets for treatment, but may also provide further insight into this debilitating and cryptic disease.

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Section: Epidemiologymentioning

confidence: 99%

Lichen Sclerosus: An autoimmunopathogenic and genomic enigma with emerging genetic and immune targets

Tran¹,

Tan²,

Macri³

et al. 2019

Int. J. Biol. Sci.

108

View full text Add to dashboard Cite

show abstract

“…However, lesions can also be disseminated throughout the body surface. 5,6 Generalized DLE has higher risks of associated systemic involvement than localized DLE. Cutaneous trauma is a significant and peculiar causative factor.…”

Section: Re Vie Wmentioning

confidence: 99%

“…The inflammatory products discharged from the initial step would be focused in the second step. 6,13 In the…”

Section: Re Vie Wmentioning

confidence: 99%

“…A first nonspecific inflammatory step adds to the creation of numerous substances, including cytokines, stress proteins, adhesion molecules, or autoantigens translocated from intracellular areas. The inflammatory products discharged from the initial step would be focused in the second step . In the second step, there might be disease explicit responses, including T cells, B cells, autoantibodies, and immune deposits under the limitation of hereditary backgrounds …”

Section: Reviewmentioning

confidence: 99%

“…DLE injuries are most as often as possible experienced in photograph distributed areas with a predilection for face, scalp, and ears. However, lesions can also be disseminated throughout the body surface . Generalized DLE has higher risks of associated systemic involvement than localized DLE.…”

Section: Reviewmentioning

confidence: 99%

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A secondary discoid lupus erythematosus induced by scald of edible oil: An illustration of Koebner phenomenon

Mei

Wei

et al. 2019

J of Cosmetic Dermatology

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Background Discoid lupus erythematosus (DLE) is a most well‐known clinical variation of chronic cutaneous lupus erythematosus inside the spectrum of lupus erythematosus (LE). Cutaneous trauma remains a significant and peculiar causative factor for DLE. Aims We present a case wherein the patient demonstrated unilateral distribution of DLE on a clinically normal appearing occult facial scald of edible oil, representing Koebner phenomenon (KP) i.e. occurrence of a new skin disease at the site of an unrelated and already healed one. Patient/Methods The 53 years old female patient was unique because she experienced DLE on the nasal back. Results The injury was totally settled following a month treatment of oral hydroxychloroquine and topical 0.03% tacrolimus ointment. After three months, she encountered an accidental edible oil scald on the right upper cheek. Several small vesicles appeared on a soybean‐sized erythema base with a burning sensation. Conclusion We review the literature and conclude by discussing important histologic highlights to think about while endeavoring to perceive the fundamental character and pathogenicity of such sores.

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Incidence, Prevalence, and Mortality of Dermatomyositis: A Population‐Based Cohort Study

Kronzer

Kimbrough

Crowson

et al. 2022

Arthritis Care & Research

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Objective. We aimed to determine the population-based incidence, prevalence, and mortality of dermatomyositis (DM) using European Alliance of Associations for Rheumatology (EULAR)/American College of Rheumatology (ACR) criteria.Methods. This population-based cohort study included incident DM from January 1, 1995 to December 31, 2019. We manually reviewed all individuals with at least 1 code for DM or polymyositis to determine if they met EULAR/ ACR criteria, subspecialty physician diagnosis, and/or Bohan and Peter criteria. We age-and sex-adjusted incidence and prevalence estimates to the US non-Hispanic White year 2000 population and estimated prevalence on January 1, 2015. Standardized mortality ratios (SMRs) with 95% confidence intervals (95% CIs) compared observed to expected mortality adjusting for age, sex, and year.Results. We identified 40 cases of verified DM, with 29 cases incident in Olmsted County from 1995 to 2019. The mean age was 57 years, 26 (90%) were female, and 12 (41%) had clinically amyopathic DM (CADM). The median follow-up time was 8.2 years. The overall adjusted incidence of DM was 1.1 (95% CI 0.7-1.5) per 100,000 person-years, and prevalence was 13 (95% CI 6-19) per 100,000. The SMR was significantly elevated among the myopathic DM cases (3.1 [95% CI 1.1-6.8]) but not CADM cases (1.1 [95% CI 0.2-3.3]). The positive predictive value of ≥2 DM codes was only 40 of 82 (49%).Conclusion. This population-based study found that DM incidence and prevalence were higher than previously reported. Mortality was significantly elevated for myopathic DM but not for CADM.The content herein is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

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Autoimmune skin disease among dermatology outpatients in Botswana: a retrospective review

Cited by 17 publications

References 21 publications

Lichen Sclerosus: An autoimmunopathogenic and genomic enigma with emerging genetic and immune targets

Lichen Sclerosus: An autoimmunopathogenic and genomic enigma with emerging genetic and immune targets

A secondary discoid lupus erythematosus induced by scald of edible oil: An illustration of Koebner phenomenon

Incidence, Prevalence, and Mortality of Dermatomyositis: A Population‐Based Cohort Study

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