Autoimmune pulmonary alveolar proteinosis with a history of vaping and vitamin <scp>E‐positive</scp> bronchoalveolar lavage

Chua, Tzy Harn; Takano, Angela; Yao, Yi Ju; Chow, Sau Yee; Anantham, Devanand; Tay, Cho Jui

doi:10.1002/rcr2.864

Cited by 2 publications

(4 citation statements)

References 13 publications

(31 reference statements)

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“…For instance, there were increased IL-6 levels in the brain, and elevated IL-6 is involved in carcinogenesis. In a study of a 33-year-old male, Chua et al noted that vaping products may have interacted with endogenous proteins and indirectly trigger autoimmune pulmonary alveolar proteinosis [ 61 ] . However, one limitation to better understanding these interactions is that this patient had previously used cannabis and e-cigarettes.…”

Section: Discussionmentioning

confidence: 99%

“…At 11 weeks of age, JUUL + HDM-exposed offspring exhibited pulmonary inflammation compared to their respective air + HDM controls. Additionally, JUUL + HDM female offspring showed decreased methylation of the promoter region of the Il10ra gene Chen et al [60] Female BALB/c mice E-cigarette liquid without nicotine and e-cigarette liquid containing 18 mg/mL of nicotine TNF-a protein levels were increased in the electronic cigarette groups (compared to controls), and IL-1b was suppressed in adult offspring. Additionally, methylation increased in the e-cigarette liquid without nicotine (~3X) and e-cigarette liquid containing 18 mg/mL of nicotine (~2X) Chua et al…”

Section: A Look Back To Cancer Risk In Offspring Of Women Who Smoked ...mentioning

confidence: 99%

“…Additionally, there is the possibility of epigenetic programming that can influence future lung disease in offspring [58] . These cascades of events in the future may be due to ENDS-associated byproducts that create a proinflammatory environment within which the fetus develops [60] .…”

Section: Epigeneticsmentioning

confidence: 99%

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Nicotine or marijuana vaping exposure during pregnancy and altered immune responses in offspring

Ndeke,

Klaunig,

Commodore

2024

J Environ Expo Assess

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Electronic nicotine delivery systems (ENDS) - which include electronic cigarettes or e-cigarettes, or simply e-cigs, and marijuana vaping have become increasingly popular. ENDS devices have been established as one of the tobacco quit methods and promoted to be safer compared to traditional tobacco cigarettes. Emerging evidence demonstrates that e-cigarette and marijuana vape use can be harmful, with potential associations with cancer. Herein, we summarize the level of evidence to date for altered immune response, with a focus on cancer risks in the offspring after maternal use of, or aerosol exposures from, ENDS or marijuana vape during pregnancy. From 27 published articles retrieved from PubMed, we sought to find out identified carcinogens in ENDS aerosols and marijuana vapor, which cross the placental barrier and can increase cancer risk in the offspring. Carcinogens in vaping aerosols include aldehydes, metals, tobacco-specific nitrosamines, tobacco alkaloids, polycyclic aromatic hydrocarbons, and volatile organic compounds. Additionally, there was only one passive vaping exposure case study on a human fetus, which noted that glycerol, aluminum, chromium, nickel, copper, zinc, selenium, and lead crossed from the mother to the offspring’s cord blood. The carcinogens (metals) in that study were at lower concentrations compared to the mother’s biological matrices. Lastly, we observed that in utero exposures to ENDS-associated chemicals can occur in vital organs such as the lungs, kidneys, brain, bladder, and heart. Any resulting DNA damage increases the risk of tumorigenesis. Future epidemiological studies are needed to examine the effects of passive aerosol exposures from existing and emerging electronic nicotine and marijuana products on developing offspring to cancer.

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Section: Discussionmentioning

confidence: 99%

Section: A Look Back To Cancer Risk In Offspring Of Women Who Smoked ...mentioning

confidence: 99%

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Nicotine or marijuana vaping exposure during pregnancy and altered immune responses in offspring

Ndeke,

Klaunig,

Commodore

2024

J Environ Expo Assess

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“…La falta de respuesta a tratamiento con esteroides llevó a lavado pulmonar luego del cual se consigue una dramática mejoría (9) . Debemos abordar algunos tópicos relativos a nuestro reporte.…”

Section: Discussionunclassified

Proteinosis alveolar pulmonar y lesión pulmonar inducida por uso de cigarrillo o vapeador electrónico (EVALI)

Aluán,

González,

Benítez Rojas

et al. 2023

Rev. Nac. (Itauguá)

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La proteinosis alveolar pulmonar es una enfermedad difusa que se debe a la acumulación de surfactante en los alveolos y que puede causar disnea y de manera progresiva llegar a fallo respiratorio. Aunque generalmente es de etiología inmunitaria, existen casos secundarios y congénitos. La lesión pulmonar inducida por uso de cigarrillo electrónico (EVALI) es una entidad descrita recientemente y tiene múltiples expresiones clínicas e histopatológicas, entre las cuales solo un par de reportes presentan a la proteinosis alveolar pulmonar como parte del espectro. Describimos el caso clínico y el manejo de un individuo y analizamos los posibles mecanismos celulares que podrían generar esta asociación.

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Autoimmune pulmonary alveolar proteinosis with a history of vaping and vitamin E‐positive bronchoalveolar lavage

Cited by 2 publications

References 13 publications

Nicotine or marijuana vaping exposure during pregnancy and altered immune responses in offspring

Nicotine or marijuana vaping exposure during pregnancy and altered immune responses in offspring

Proteinosis alveolar pulmonar y lesión pulmonar inducida por uso de cigarrillo o vapeador electrónico (EVALI)

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