Autoimmune phenomena in bronchial asthma with special reference to aspirin intolerance.

Szczeklik, A; Nizankowska, E; Serafin, A; Dyczek, Andrzej; Duplaga, Mariusz; Musiał, Jacek

doi:10.1164/ajrccm.152.6.8520733

Cited by 63 publications

(53 citation statements)

References 11 publications

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“…Cross-linking of the IgE-loaded high-affinity IgE receptor by multivalent antigens results in mast cell activation and subsequent release of multiple proinflammatory mediators [20]. The autoantibodies against FcεRI or IgE may be involved in the pathogenesis of asthma [17,18,19]. We found that 28.6% of asthma patients revealed positive autoantibodies against FcεRI or IgE, suggesting that autoimmunity may be involved in the pathogenesis of asthma.…”

Section: Discussionmentioning

confidence: 99%

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Autologous Serum Skin Test for Autoantibodies Is Associated with Airway Hyperresponsiveness in Patients with Asthma

Jang

Park²,

Lee³

et al. 2006

Respiration

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Background: Autoimmune diseases have been implicated as a cause of intrinsic asthma; however, there is little data on the role of autoimmunity in the pathogenesis of asthma. Objective: The purpose of this study was to investigate circulating functional autoantibodies against the high-affinity IgE receptor FcΕRI or IgE in patients with asthma. Methods: Twenty-eight patients with asthma and 19 control subjects were included. All subjects were skin tested with autologous serum to assess for the potential presence of receptor FcΕRI or IgE autoantibodies. If the serum-induced wheal diameter was 1.5 mm larger than the histamine-induced wheal diameter and that was 3 mm larger than the saline-induced wheal diameter at 30 min, the reaction was defined positive. Results: Of the 47 total subjects (both asthma patients and control subjects), 13 (27.7%) had a positive autologous serum skin test (ASST). Of the 28 asthma patients, 8 (28.6%) were regarded as having autoimmune origin. Autoantibodies against FcΕRI or IgE were found in asthma patients, irrespective of atopic status (atopy+ 3/13 vs. atopy– 5/15). The wheal diameter related to ASST was not related to atopy. Asthma patients with ASST-positive results as compared with patients with ASST-negative results exhibited a significant increased airway hyperresponsiveness (PC₂₀ methacholine, 2.70 ± 1.27 vs. 9.08 ± 2.35; p < 0.026). Conclusion: Our data demonstrate that aberrant autoantibodies against the high-affinity IgE receptor FcΕRI or IgE are related to airway hyperresponsiveness in patients with asthma.

show abstract

Section: Discussionmentioning

confidence: 99%

“…The possible involvement of autoimmunity in the pathogenesis of asthma has been proposed by few studies [15,16,17,18,19]. FcεRI is a multimeric surface receptor that is expressed exclusively as a tetramer on rodent cells, but exists as a tetramer or trimer on human cells.…”

Section: Discussionmentioning

confidence: 99%

Autologous Serum Skin Test for Autoantibodies Is Associated with Airway Hyperresponsiveness in Patients with Asthma

Jang

Park²,

Lee³

et al. 2006

Respiration

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show abstract

“…The idea of a possible involvement of autoimmunity in the pathogenesis of asthma has been proposed by earlier studies that demonstrated higher incidences of various autoantibodies against antigens in bronchial mucosa, paranasal sinus, lung, endothelial cells, and nuclei in patients with asthma, compared with healthy control subjects (7)(8)(9)(17)(18)(19). However, these observations could not establish a causal relationship between autoimmunity and asthma, partly due to lack of an identified autoantigen or lack of a logical association between these autoantibodies and airway inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…In some patients, asthma developed into the Churg-Strauss syndrome, a distinct form of systemic vasculitis characterized by eosinophilia, lung infiltration, paranasal sinus abnormality, and neuropathy (27). Rheumatic symptoms were reported to be more common among the patients with asthma with antinuclear antibodies (19). These observations suggest that asthma might be a systemic inflammatory disease in a subgroup of patients with asthma.…”

Section: Discussionmentioning

confidence: 99%

Identification of Cytokeratin 18 as a Bronchial Epithelial Autoantigen Associated with Nonallergic Asthma

Nahm

Lee

Yim

et al. 2002

Am J Respir Crit Care Med

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The allergic response to common environmental agents (allergens) has been regarded as an important mechanism in the development of airway inflammation of patients with asthma. However, allergic sensitization cannot be detected in a significant number of adult patients with asthma. The etiologic mechanism responsible for nonallergic asthma has not yet been identified. The idea of a possible involvement of autoimmunity in the pathogenesis of nonallergic asthma has been proposed by earlier studies. To test for the possible presence of an autoimmune response to bronchial epithelial cell antigens in nonallergic asthma, we examined circulating autoantibodies to cultured human bronchial epithelial cells (BEAS-2B) in sera from patients with nonallergic asthma by immunoblot analysis. IgG autoantibodies to the 49-kD bronchial epithelial cell antigen were detected in 10 of 23 patients with nonallergic asthma (43%), 3 of 27 patients with allergic asthma (11%), 2 of 20 patients with systemic lupus erythematosus (10%), and 3 of 34 healthy volunteers (9%) (p Ͻ 0.005). The 49-kD autoantigen was purified and identified as cytokeratin 18 by amino acid sequencing. In this study, we identified cytokeratin 18 as a bronchial epithelial autoantigen associated with nonallergic asthma. Further studies are needed to determine the significance of autoimmunity in nonallergic asthma.

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“…The idea of a possible involvement of autoimmunity in the pathogenesis of asthma has been proposed by few studies as already reviewed above. Szczeklik et al [19]assessed the autoimmune status of 185 adult patients with bronchial asthma and 46 healthy subjects of similar sex and age. The patients were divided into groups with aspirin-induced asthma, intrinsic asthma with good aspirin tolerance, and atopic asthma.…”

Section: Common Pathogenic Mechanismsmentioning

confidence: 99%

Asthma as a Paradigm for Autoimmune Disease

Rottem

Shoenfeld

2003

Int Arch Allergy Immunol

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Allergy and autoimmunity result from dysregulation of the immune system. Until recently, it was generally accepted that the mechanisms that govern these disease processes are quite disparate; however, new discoveries suggest possible common pathogenetic effector pathways. This review illustrates the concomitant presentation of these conditions and the potential relationship or common mechanisms in some cases, by looking at the key elements that regulate the immune response in both asthma and autoimmune conditions: mast cells, antibodies, T cells, cytokines, and genetic determinants. The parallel appearance of asthma and autoimmune conditions in the same patients may reveal that such aberrations of the immune system have a common pathophysiologic mechanism. Mast cells, which play a key role in asthma, and the wealth of inflammatory mediators they express, make it likely that they have profound effects on many autoimmune processes. Activation of protein kinases by inflammatory cytokines and environmental stresses may contribute to both allergic and autoimmune diseases. The presence of autoantibodies in some allergic diseases suggests an autoimmune basis for these conditions. Because of the central role T cells play in immune reactivity, the T cell receptor loci have long been considered important candidates for a common disease susceptibility within the immune system such as asthma, atopy, and autoimmunity. Immunomodulation is the key to successful treatment of asthma and autoimmune conditions.

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Autoimmune phenomena in bronchial asthma with special reference to aspirin intolerance.

Cited by 63 publications

References 11 publications

Autologous Serum Skin Test for Autoantibodies Is Associated with Airway Hyperresponsiveness in Patients with Asthma

Autologous Serum Skin Test for Autoantibodies Is Associated with Airway Hyperresponsiveness in Patients with Asthma

Identification of Cytokeratin 18 as a Bronchial Epithelial Autoantigen Associated with Nonallergic Asthma

Asthma as a Paradigm for Autoimmune Disease

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