Autoimmune Pathogenesis in Dengue Virus Infection

Lin, Chiou Feng; Wan, Shu; Cheng, Hsien Jen; Lei, Huan Yao; Lin, Yee Shin

doi:10.1089/vim.2006.19.127

Cited by 139 publications

(126 citation statements)

References 59 publications

Supporting

Mentioning

112

Contrasting

Unclassified

Order By: Relevance

“…The levels of the terminal SC5b-9 complement complex and plasma NS1 correlated with disease severity, suggesting links between the virus, complement activation and the development of DHF/DSS 50 . Alternative hypotheses of dengue pathogenesis include the suggestions that secondary T-cell responses are blunted because stimulation of T-cell memory results in the production of heterotypic CD4 + and CD8 + cells that have a diminished capacity to kill but nonetheless release inflammatory cytokines that contribute to disease severity 51 ; that severe disease is caused by DENVs of increased virulence 52 ; and the suggestion that cross-reactivity between NS1 and human platelets and endothelial cells raises antibodies that damage these cells 53 .…”

Section: Dengue Virus Pathogenesismentioning

confidence: 99%

See 1 more Smart Citation

Dengue: a continuing global threat

et al. 2010

View full text Add to dashboard Cite

Dengue fever and dengue haemorrhagic fever are important arthropod-borne viral diseases. Each year, there are ~50 million dengue infections and ~500,000 individuals are hospitalized with dengue haemorrhagic fever, mainly in Southeast Asia, the Pacific and the Americas. Illness is produced by any of the four dengue virus serotypes. A global strategy aimed at increasing the capacity for surveillance and outbreak response, changing behaviours and reducing the disease burden using integrated vector management in conjunction with early and accurate diagnosis has been advocated. Antiviral drugs and vaccines that are currently under development could also make an important contribution to dengue control in the future.Dengue is the most important arthropod-borne viral infection of humans. Worldwide, an estimated 2.5 billion people are at risk of infection, approximately 975 million of whom live in urban areas in tropical and sub-tropical countries in Southeast Asia, the Pacific and the Americas 1 . Transmission also occurs in Africa and the Eastern Mediterranean, and rural Europe PMC Funders GroupAuthor Manuscript Nat Rev Microbiol. Author manuscript; available in PMC 2015 February 19. Published in final edited form as:Nat Rev Microbiol. 2010 December ; 8(12 0): S7-16. doi:10.1038/nrmicro2460. Europe PMC Funders Author ManuscriptsEurope PMC Funders Author Manuscripts communities are increasingly being affected. It is estimated that more than 50 million infections occur each year, including 500,000 hospitalizations for dengue haemorrhagic fever, mainly among children, with the case fatality rate exceeding 5% in some areas [1][2][3][4] . The geographical areas in which dengue transmission occurs have expanded in recent years (FIG. 1), and all four dengue virus serotypes (DENV-1-4) are now circulating in Asia, Africa and the Americas, a dramatically different scenario from that which prevailed 20 or 30 years ago (FIG. 2). The molecular epidemiology of these serotypes has been studied in an attempt to understand their evolutionary relationships 11 .This Review will provide an update on our understanding of the pathogenesis of this successful pathogen, how we diagnose and control infection and the progress that has been made in vaccine development. Dengue virus pathogenesisDengue viruses belong to the genus flavivirus within the Flaviviridae family. DENV-1-4 evolved in non-human primates from a common ancestor and each entered the urban cycle independently an estimated 500-1,000 years ago 12 . The virion comprises a spherical particle, 40-50 nm in diameter, with a lipopolysaccharide envelope. The positive singlestrand RNA genome (FIG. 3), which is approximately 11 kb in length, has a single open reading frame that encodes three structural proteins -the capsid (C), membrane (M) and envelope (E) glycoproteins -and seven non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5 [18][19][20] . ADE occurs when mononuclear phagocytes are infected through their Fc receptors by immune complexes that form between DE...

show abstract

Section: Dengue Virus Pathogenesismentioning

confidence: 99%

“…It is also widely used to classify primary or secondary infections 53,54,63,64 . Some protocols use serum dilutions to titre dengue-specific IgG 83 and others use the ratio of IgM to IgG 66,84 .…”

Section: Igg Elisamentioning

confidence: 99%

Dengue: a continuing global threat

et al. 2010

View full text Add to dashboard Cite

show abstract

“…4 This protein also parallels cellular dengue infection. High levels of markers of immune activation and severity of dengue infection have led to the hypothesis of an autoimmune response, mainly as a result of crossreactivity between anti-NS1 to host proteins, endothelial cells and platelets, 5,6 mediating complement activation 3 and triggering plasma leakage. Molecular mimicry could be involved in the pathogenesis of this autoimmune activation.…”

Section: Discussionmentioning

confidence: 99%

Autoimmune features caused by dengue fever: a case report

Jardim¹,

Tsukumo²,

Angerami³

et al. 2012

Braz J Infect Dis

View full text Add to dashboard Cite

Autoimmunity Hematologic diseases A B S T R A C TDengue virus is the most important mosquito-borne viral disease in the world. Co-circulation of the four types of dengue viruses and expansion of dengue epidemic gave rise to infection enhancement and a big expansion of clinical aspects of the disease. Herein we report a case of a 25-year-old white woman with dengue fever and numerous associated autoimmune features.Our patient had proteinuria, an extensive right pleural effusion, a thin pericardial effusion and ascites. She had a low C3 level and positive antinuclear antibody; cryoglobulins were also positive. The numerous autoimmune features of this patient were a diagnostic challenge, since she was a young woman and could be easily mistaken for a rheumatologic patient in a newly open disease. Dengue infection probably was a triggering event causing an abnormal immune response. Therefore, dengue should be suspected in patients with hematological disorders and autoimmune features in endemic regions or those who have travelled to those regions.

show abstract

“…La presencia de anticuerpos antiplaquetarios en casos de infección por dengue ha sido evaluada en varios estudios (54-62), los cuales han informado la presencia de autoanticuerpos tanto de tipo IgM (58) como de tipo IgG (61,62), sin diferenciar entre infección primaria y secundaria. Sin embargo, se ha logrado evidenciar mayores niveles de anticuerpos antiplaquetarios en los pacientes con dengue hemorrágico y síndrome de choque por dengue, que en pacientes con dengue clásico (58).…”

Section: Virus Del Dengueunclassified

“…Existen algunas teorías que intentan explicar su aparición. La primera es que algunos epítopos antigénicos del virus del dengue, como la proteína NS1, inducen la formación de anticuerpos con reactividad cruzada contra las plaquetas (62)(63)(64); otra es que la activación policlonal de los linfocitos B conduce a la producción de anticuerpos heterotípicos capaces de reaccionar contra las plaquetas (57,61). Consideramos que estas dos posibilidades no son mutuamente excluyentes y podrían participar de forma sinérgica en la generación de la trombocitopenia.…”

Section: Virus Del Dengueunclassified

Papel de los anticuerpos antiplaquetarios en la infección viral: una revisión sistemática de la literatura

et al. 2011

View full text Add to dashboard Cite

Introducción. La trombocitopenia es un fenómeno frecuente en las infecciones virales. Uno de los mecanismos propuesto como posible explicación de su desarrollo es la destrucción plaquetaria periférica mediada por anticuerpos antiplaquetarios. Objetivo. Revisar los resultados de los trabajos originales que existen en la literatura sobre infección viral y anticuerpos antiplaquetarios en humanos, y su efecto sobre el recuento total de plaquetas. Materiales y métodos. Se hizo una búsqueda en PubMed empleando la combinación de términos: "viral infection (OR Virus diseases) AND antibody antiplatelet (OR thrombocytopenia); y antibody antiplatelet AND HIV (OR Measles, OR Dengue, OR Chickenpox OR varicella, OR Epstein Barr, OR Mumps, OR Rubella". Se obtuvieron 218 referencias, de las cuales, 65 correspondían al objetivo de la revisión. Resultados. En la búsqueda se encontró que la trombocitopenia mediada por anticuerpos antiplaquetarios se ha documentado en infecciones virales por VIH, sarampión, dengue, varicelazóster, Epstein-Barr, parotiditis y rubéola. La presencia de anticuerpos antiplaquetarios en infecciones virales por VIH, virus de Epstein-Barr y dengue, se ha asociado con la presencia de la trombocitopenia y con la gravedad de la enfermedad. Conclusiones. Aunque la aparición de anticuerpos antiplaquetarios no se considera el único mecanismo que explica la trombocitopenia desarrollada en las infecciones virales mencionadas, de acuerdo con la literatura científica disponible, su presencia se asocia con la gravedad de la trombocitopenia y con potenciales implicaciones clínicas en los pacientes.Palabras clave: virosis, anticuerpos, plaquetas, trombocitopenia, humanos. Roll of antibodies antiplatelets in viral infection: a systematic review of literatureIntroduction. Thrombocytopenia is a frequent phenomenon in viral infections. Peripheral platelet destruction mediated by anti-platelet antibodies has been one of the proposed causal mechanisms. Objective. Results were collected and analyzed from published studies on associations of human viral infections on anti-platelet antibodies and total platelet counts. Materials and methods. A PubMed search was conducted using the following terms: Viral infection (OR Virus diseases) AND antiplatelet antibody (OR thrombocytopenia) AND HIV (OR measles OR dengue OR chickenpox OR varicella OR Epistein Barr OR mumps OR rubella). Two hundred eighteen reference hits were obtained, 65 of which were relevant to this review. Results. Antiplatelet antibody-mediated thrombocytopenia has been documented in cases of HIV, measles, dengue, chickenpox, Epstein-Barr, mumps and rubella. Moreover, the presence of these antibodies has been associated with severity the disease and thrombocytopenia in viral infections. Conclusions. Although the presence of antiplatelet antibodies was not the only mechanism for explaining the thrombocytopenia developed in these viral infections, their presence was associated with severity of thrombocytopenia and with the clinical presentation of these patients.

show abstract

Autoimmune Pathogenesis in Dengue Virus Infection

Cited by 139 publications

References 59 publications

Dengue: a continuing global threat

Dengue: a continuing global threat

Autoimmune features caused by dengue fever: a case report

Papel de los anticuerpos antiplaquetarios en la infección viral: una revisión sistemática de la literatura

Contact Info

Product

Resources

About