Autoimmune pancreatitis: radiologic findings in 20 patients

Yang, Dong Hyun; Kim, K. W.; Kim, T. K.; Park, S. H.; Kim, S. H.; Kim, M. H.; Lee, S. K.; Kim, A. Y.; Kim, P. N.; Ha, Hyun Kwon; Lee, M.-G.

doi:10.1007/s00261-005-0047-8

Cited by 86 publications

(69 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our experience of 112 AIP patients, focal or segmental swelling was observed in 23.2%, and other authors have reported 9 -30% frequencies [45][46][47]. In addition, AIP with multifocal lesions has been reported [51][52][53][54] and was found in 7.1% of our cases (Fig.…”

Section: Atypical Findings Of Aipsupporting

confidence: 58%

See 1 more Smart Citation

Radiologic Findings of IgG4-Related Disease

Fujinaga¹,

Kadoya²,

Hamano³

et al. 2011

CIR

View full text Add to dashboard Cite

Section: Atypical Findings Of Aipsupporting

confidence: 58%

“…To date, we have diagnosed 112 AIP patients and observed diffuse pancreatic swelling in 53.6% and a capsule-like rim in 29.5%. Other studies with large cohorts showed diffuse pancreatic swelling in 22 -95% of patients and a capsule-like rim in 12 -90% [45][46][47].…”

mentioning

confidence: 85%

Radiologic Findings of IgG4-Related Disease

Fujinaga¹,

Kadoya²,

Hamano³

et al. 2011

CIR

View full text Add to dashboard Cite

“…This non-invasive approach is useful not only for evaluating the location, distribution, and degree of the biliary strictures by MR cholangiopancreatography, but also for demonstrating other abnormalities such as bile duct wall thickening and unusual enhancement patterns using pre-contrast and dynamic contrast-enhanced MR images. In patients with concomitant AIP, the pancreas shows imaging abnormalities highly specific for the diagnosis (e.g., diffuse enlargement, capsule-like rim around the pancreas, and irregular narrowing of the main pancreatic duct) [39,40]; therefore, the diagnostic approach needs to primarily target the pancreatic lesion. CT and MR imaging also sometimes depict IgG4-RD in other intra-abdominal organs unexpectedly.…”

Section: Ct/mrmentioning

confidence: 99%

IgG4-related sclerosing cholangitis: all we need to know

2016

View full text Add to dashboard Cite

Our knowledge and experience of IgG4-related sclerosing cholangitis (ISC) have expanded in the last decade. ISC is one of the common organ manifestations of IgG4-related disease (IgG4-RD); approximately 60 % of patients with this systemic condition have ISC in the proximal and/or distal bile ducts. ISC needs to be discriminated from primary sclerosing cholangitis, cholangiocarcinoma, and other rare forms of lymphoplasmacytic cholangiopathy (e.g., follicular cholangitis and sclerosing cholangitis with granulocytic epithelial lesions). Its diagnosis requires a multidisciplinary approach, in which serology, histology, and imaging play crucial roles. Treatments with high-dose corticosteroids typically lead to the rapid and consistent induction of disease remission. Another promising therapeutic approach is B-cell depletion with rituximab. Although disease relapse is relatively common, provided that appropriate treatments are administered, ISC is considered a ''benign'' disease with a low risk of liver failure and biliary malignancy. Its molecular pathology is characterized by Th2-dominant immune reactions, regulatory T-cell activation, and CCL1-CCR8 interactions. Particular subsets of B cells such as plasmablasts and regulatory B cells also expand. A recent global proteomic study demonstrated that three significantly activated immunological cascades in ISC were all B-cell-or immunoglobulin-related (Fc-gamma receptormediated phagocytosis, B-cell receptor signaling pathway, and Fc-epsilon receptor I signaling pathway), suggesting the crucial roles of B cells in the underlying immune reactions. Despite the expansion of our knowledge of the pathophysiology of ISC, the exact role of IgG4 remains unclear. A better understanding of its immunopathology will offer some potential drug targets for this emerging biliary disease.

show abstract

“…4,5 In an appropriate clinical setting, a constellation of imaging features is very helpful in the diagnosis of AIP. The abnormal findings are reversible with steroid therapy and thus imaging can be used as an evaluation of treatment response.…”

Section: Speaker: Jae Hoon Limmentioning

confidence: 99%

Conference Report: Korea-Japan Symposium on Autoimmune Pancreatitis

Park

Chung

Ōtsuki³

et al. 2008

Gut Liver

View full text Add to dashboard Cite

A consensus meeting on autoimmune pancreatitis (AIP) was held in Seoul on August 31, 2007. Many Korean and Japanese gastroenterologist interested in AIP participated in the joint symposium, and issues related to histology, radiology, clinical manifestation, serology, and diagnostic criteria were discussed. This joint meeting indicated the need for unified diagnostic criterion for AIP in Korea and Japan. Here, we provide a summary of the symposium presentations and discussions. (Gut and Liver 2008;2:81-87)

show abstract

Autoimmune pancreatitis: radiologic findings in 20 patients

Cited by 86 publications

References 19 publications

Radiologic Findings of IgG4-Related Disease

Radiologic Findings of IgG4-Related Disease

IgG4-related sclerosing cholangitis: all we need to know

Conference Report: Korea-Japan Symposium on Autoimmune Pancreatitis

Contact Info

Product

Resources

About