Autoimmune Orchitis Induced by Autoimmunization With Seminal Plasma in the Rabbit

Yantorno, C; Debanne, Maria T.; Vottero-Cima, E

doi:10.1530/jrf.0.0270311

Cited by 34 publications

(9 citation statements)

References 10 publications

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“…Saline extract of RAG from syngeneic rats were prepared as described in the work of Yantorno et al [12]. MRAG were prepared by coupling their proteins with diazonium derivates of arsanilic and sulfanilic acid following a procedure described previously [13].…”

Section: Animals and Antigensmentioning

confidence: 99%

Antigen‐induced inhibition of autoimmune response to rat male accessory glands: distinct characteristics of I‐A‐ and I‐E‐positive peritoneal cells

et al. 1991

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The present report describes different aspects of two populations of peritoneal cells (PC) obtained from rats injected i.p. 2 h or 24 h previously with a suppressor dose of a purified fraction (FI) of rat male accessory glands (RAG) (FI-PC2h and FI-PC24h, respectively). The FI-PC2h, which are mainly I-E (OX17) positive and can suppress the autoimmune response to RAG autoantigens, have an elevated phagocytic activity against Candida albicans and capacity to reduce the dye nitroblue tetrazolium. In contrast, FI-PC24h, which are mainly I-A (OX6) positive and can potentiate the autoimmunity to RAG autoantigens, have a diminished capacity to reduce the dye and a diminished phagocytic activity. Moreover, the Toxoplasma gondii appear to have a different effect on both populations. The parasites can invade FI-PC2h while FI-PC24h offer resistance to T. gondii aggression. FI-PC2h cultured during 22 h (FI-PC2-24h in vitro), or PC obtained from syngeneic recipients injected i.p. 22 h previously with FI-PC2h (FI-PC2-24h in vivo) show, as FI-PC2h, an increase of the I-E+ cells and capacity to induce suppression of the delayed-type hypersensitivity response to RAG autoantigens when they are injected to syngeneic rats 10 and 3 days prior to the immunization with chemically modified (diazotized arsanilic and sulfanilic acid) RAG in complete Freund's adjuvant. The PC obtained 24 h after injection of irradiated rats with N-PC plus FI show an increase of I-E+ cells whereas an enhancement of I-A+ cells can be observed when the PC are obtained 24 h after injection of irradiated and bone marrow-reconstituted rats with N-PC plus FI. These findings appear to indicate that FI-PC2h and FI-PC24h are functionally different and that the population obtained 24 h after injection of FI of RAG could not originate from either the population present 2 h after injection of FI of RAG injection nor from normal PC. They appear to require bone marrow precursors.

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Section: Animals and Antigensmentioning

confidence: 99%

Antigen‐induced inhibition of autoimmune response to rat male accessory glands: distinct characteristics of I‐A‐ and I‐E‐positive peritoneal cells

et al. 1991

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“…Saline extract of RAG was prepared as described previously by Yantorno et al [8]. Chemically modified RAG (MRAG) saline ex tract was prepared by coupling RAG to diazonium dérivâtes of arsanilic and sulfanilic acid following the procedure described by Vottero-Cima et al [3].…”

Section: Antigensmentioning

confidence: 99%

Characterization of an Antigen from Rat Male Accessory Glands

Pesoa¹,

Galmarini²,

Pistoresi-Palencia³

et al. 1986

Int Arch Allergy Immunol

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An isolated soluble antigen involved in the autoimmune response against rat male accessory glands migrated as a double band when it was submitted to analytical disc polyacrylamide gel electrophoresis and as a homogeneous molecular species in SDS electrophoresis. The purified antigen had a molecular weight of approximately 78 K by SDS electrophoresis and 80 K by gel filtration chromatography. The antigen was identified as a protein and displays androgen dependency. The purified fraction was pathogenically active in microgram doses and induced humoral and delayed-type hypersensitivity responses. Besides, lesions were observed in the target organ. The cellular infiltration was located in prostate glands according to the localization of antigen by immunofluorescence findings.

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“…Saline extract of rat male accessory glands (RAG) was prepared as already described [4]. Chemically MRAG was prepared by cou pling to diazonium derivatives of arsanilic and sulphanilic acid fol lowing an earlier procedure [5].…”

Section: Antigensmentioning

confidence: 99%

Humoral Autoimmune Response to Rat Male Accessory Glands

Vottero-Cima¹,

Galmarini²,

Pesoa³

et al. 1984

Int Arch Allergy Immunol

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The ability to induce antibodies to rat male accessory glands in male and female rats was demonstrated, but a higher response with wider specificity was revealed in female animals. In order to investigate whether this different response may be influenced by sexual hormones we castrated male and female rats at 4 or 30 days after birth. After that we studied the course and specificity of their humoral response to male accessory glands comparing them with that of sham-operated, sex-matched, littermate controls. Orchidectomy in male or oophorectomy in female rats changed neither the course nor specificity of humoral immune response. We conclude, therefore, that hormonal factors do not play any important role in the experimental model under study.

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Autoimmune Orchitis Induced by Autoimmunization With Seminal Plasma in the Rabbit

Cited by 34 publications

References 10 publications

Antigen‐induced inhibition of autoimmune response to rat male accessory glands: distinct characteristics of I‐A‐ and I‐E‐positive peritoneal cells

Antigen‐induced inhibition of autoimmune response to rat male accessory glands: distinct characteristics of I‐A‐ and I‐E‐positive peritoneal cells

Characterization of an Antigen from Rat Male Accessory Glands

Humoral Autoimmune Response to Rat Male Accessory Glands

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