Autoimmune mechanisms in children with systemic lupus erythematosus

Stichweh, Dorothee; Pascual, Virginia

doi:10.1007/s11926-005-0045-4

Cited by 4 publications

(5 citation statements)

References 64 publications

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“…In cystic fibrosis, a disease characterized by chronic infection and persistently elevated levels of inflammatory cytokines like IL-6, exercise leads to larger acute increases in IL-6 than observed in controls in both children and adults (56,143). In systemic lupus erythematosis, a systemic autoimmune disease (134), brief exercise leads to abnormal cortisol, prolactin, and CD4ϩ/CD8ϩ T-cell responses (110). In pediatric arthritis, particularly systemic forms, strenuous exercise may actually exacerbate symptoms and lead to episodes of disease flare-up with pain and, on occasion, systemic manifestations of disease, including fever and malaise (personal observation and Ref.…”

Section: Lessons Learned From Dysregulated Immune Responses To Exercisementioning

confidence: 99%

Dangerous exercise: lessons learned from dysregulated inflammatory responses to physical activity

Cooper¹,

Radom‐Aizik²,

Schwindt³

et al. 2007

Journal of Applied Physiology

123

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Exercise elicits an immunological "danger" type of stress and inflammatory response that, on occasion, becomes dysregulated and detrimental to health. Examples include anaphylaxis, exercise-induced asthma, overuse syndromes, and exacerbation of intercurrent illnesses. In dangerous exercise, the normal balance between pro- and anti-inflammatory responses is upset. A possible pathophysiological mechanism is characterized by the concept of exercise modulation of previously activated leukocytes. In this model, circulating leukocytes are rendered more responsive than normal to the immune stimulus of exercise. For example, in the case of exercise anaphylaxis, food-sensitized immune cells may be relatively innocuous until they are redistributed during exercise from gut-associated circulatory depots, like the spleen, into the central circulation. In the case of asthma, the prior activation of leukocytes may be the result of genetic or environmental factors. In the case of overuse syndromes, the normally short-lived neutrophil may, because of acidosis and hypoxia, inhibit apoptosis and play a role in prolongation of inflammation rather than healing. Dangerous exercise demonstrates that the stress/inflammatory response caused by physical activity is robust and sufficiently powerful, perhaps, to alter subsequent responses. These longer term effects may occur through as yet unexplored mechanisms of immune "tolerance" and/or by a training-associated reduction in the innate immune response to brief exercise. A better understanding of sometimes failed homeostatic physiological systems can lead to new insights with significant implication for clinical translation.

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Section: Lessons Learned From Dysregulated Immune Responses To Exercisementioning

confidence: 99%

Dangerous exercise: lessons learned from dysregulated inflammatory responses to physical activity

Cooper¹,

Radom‐Aizik²,

Schwindt³

et al. 2007

Journal of Applied Physiology

123

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“…Systemic lupus erythematosus (SLE) is a debilitating autoimmune syndrome that is most prevalent among women and is characterized by antibodies against many tissues and multiorgan involvement. The etiology of SLE is unknown, but is believed to result from genetic, hormonal, and environmental factors (1). Management of this syndrome comprises the administration of antiinflammatory and/or immunosuppressive drugs dependent upon symptom severity.…”

Section: Introductionmentioning

confidence: 99%

High risk of human papillomavirus type 16 infections and of development of cervical squamous intraepithelial lesions in systemic lupus erythematosus patients

Nath¹,

Mant²,

Luxton³

et al. 2007

Arthritis & Rheumatism

111

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Objective. To determine rates of human papillomavirus (HPV) infections, abnormal cervical smears, and squamous intraepithelial lesions (SIL) among women with systemic lupus erythematosus (SLE). Methods. We investigated 30 women with SLE, 67 with abnormal smears from colposcopy clinics, and 15 community subjects with normal smears. Polymerase chain reaction results for viral DNA and HPV-16 sequencing data were correlated to cytology and colposcopic findings. . SLE patients were also more likely to be HPV-16 DNA positive than colposcopy patients (P < 0.05). SLE patients with a high HPV-16 viral load more frequently had SIL (n ‫؍‬ 6) than those with a low HPV-16 viral load (n ‫؍‬ 1; P < 0.05). HPV and HPV-16 DNA positivity were not associated with previous or current drug therapy for SLE patients. All HPV-16 DNA sequences from 6 SLE and 5 colposcopy patients were the European-type variant. Eighteen (60%) SLE patients had a previous or current cervical abnormality. At the time of study, 5 (17%) SLE patients had an abnormal cervical smear and 8 (27%) had SIL. For those diagnosed with SLE for >10 years, the rate of SIL was 44% lower than those with SLE for <5 years (odds ratio 0.56, 95% confidence interval 0.1-3.5). Conclusion. UK women with a recent SLE diagnosis had disturbingly elevated levels of HPV infections (particularly with European HPV-16 variants at a high viral load), abnormal cervical cytology, and SIL. KEY WORDS. Systemic lupus erythematosus; Human papillomavirus infection; Cervical squamous intraepithelial lesions.

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“…The disease is characterized by an immune dysregulation, with the presence of activated helper T-cells that induce a Bcell response, resulting in production of autoantibodies directed against self antigens (mainly nuclear components, particularly DNA, RNA, and nuclear proteins) [4]. The resulting circulating immune complexes, with complement activation, trigger an inflammatory vasculitis in the skin, joints, kidneys, lungs, brain, serosa, heart and the gastrointestinal tract.…”

Section: Discussionmentioning

confidence: 99%

Juvenile Systemic Lupus Erythematosus

Narchi¹,

Amirlak²

2007

CPR

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Systemic lupus erythematosus (SLE) is an uncommon chronic autoimmune disease in children. In view of its insidious onset and protean manifestations which may involve any body organ system, the diagnosis may become difficult and challenging.We review this condition, and begin by reporting three affected children to highlight its very different modes of presentation.An up-to-date review of the disease is then presented, including diagnosis, complications and recommended therapy including new therapeutic modalities

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Autoimmune mechanisms in children with systemic lupus erythematosus

Cited by 4 publications

References 64 publications

Dangerous exercise: lessons learned from dysregulated inflammatory responses to physical activity

Dangerous exercise: lessons learned from dysregulated inflammatory responses to physical activity

High risk of human papillomavirus type 16 infections and of development of cervical squamous intraepithelial lesions in systemic lupus erythematosus patients

Juvenile Systemic Lupus Erythematosus

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