Autoimmune Manifestations of Acute Mercury Toxicity

Lu, Monica; Khera, Sofia

doi:10.1177/0009922820915885

Cited by 4 publications

(4 citation statements)

References 9 publications

(10 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However even subclinical mercury exposure has been linked to autoimmune disease including CASPR/LGI1/VGKC syndromes, with multiple mechanisms for this pathogenesis proposed. 7 , 8 Pediatric data is evolving, but our patient's deviation from typical patterns of autoimmunity supports the potential for mercury's causative role in inducing this rare syndrome. To the authors’ knowledge, this is the youngest documented case of mercury-induced limbic encephalitis.…”

Section: Introductionsupporting

confidence: 51%

“…Therapies used in mercury-induced Morvan syndrome included, chelation therapy, corticosteroids, and/or IVIg with gradual resolution of symptoms within 6 months in most patients. 7 , 8 Our patient's symptoms were diffuse and lacked other organ involvement characteristic of primary mercury toxicity so chelation therapy was not administered. Furthermore, given incomplete response to steroids and IVIg, our patient was treated with Rituximab, previously reported to promote complete resolution of symptoms when glucocorticoids and IVIg alone were unsuccessful.…”

Section: Discussion/conclusionmentioning

confidence: 91%

See 1 more Smart Citation

Mercury Induced Autoimmunity: A Case of CASPR2/LGI1 Autoimmune Encephalitis in a 14-Month-old

Heller,

Nolan,

Rametta

2024

Child Neurology Open

View full text Add to dashboard Cite

Contactin-associated protein-like 2 (CASPR2) autoantibodies are among those associated with several syndromes with effects on both the central and peripheral nervous systems including neuropathy and encephalitis and is most commonly seen in middle-aged to elderly males. We present a case of autoimmune encephalitis in a 14-month-old female presenting with altered mental status, refusal to bear weight, and hypertension in the setting of mercury exposure. This is the youngest reported case of CASPR2/LGI1/VGKC antibody associated autoimmune encephalitis stimulated by mercury exposure.

show abstract

Section: Introductionsupporting

confidence: 51%

Section: Discussion/conclusionmentioning

confidence: 91%

Mercury Induced Autoimmunity: A Case of CASPR2/LGI1 Autoimmune Encephalitis in a 14-Month-old

Heller,

Nolan,

Rametta

2024

Child Neurology Open

View full text Add to dashboard Cite

show abstract

“…Like accidental spillage of a bottle of Hg beads, therapeutic use of mercuric iodide, use of skin whitener, and taking indigenous or ayurvedic medicine. [53][54][55][56][57] Similarly, Malkani et al noted anti-Purkinje cell cytoplasmic-type Tr antibody positivity in a case of elemental mercury toxicity presenting with cerebellar ataxia. 30 In a developing country like India, ayurvedic drugs containing Hg are still being used abundantly and the physician should never forget to take detailed drug history when a patient presents with such phenotype.…”

Section: Mercury and Autoimmune Movement Disordersmentioning

confidence: 99%

Mercury and Movement Disorders: The Toxic Legacy Continues

Ganguly

Kulshreshtha

Jog

2021

Can. J. Neurol. Sci.

View full text Add to dashboard Cite

Mercury (Hg) exists in the environment as inorganic (metallic Hg vapor, mercurous and mercuric salts) or organic (bonded to a structure containing carbon atoms) forms. Neurotoxic effect of Hg is known for years. While the organic form (methylmercury (meHg)) led to the Minamata incidence in Japan and “wonder-wheat” disaster in Iraq, the “mad hatters” and “Danbury shakes” were related to the inorganic elemental form (Hg vapor). Human exposure to toxic Hg continues in the modern world to a large extent by artisanal gold mining, biomass combustion, chloralkali production, and indigenous medicine use to name a few. Heavy industrial use of Hg contaminates air and landfills, affecting the aquatic ecosystem and marine food chain. A detailed social and occupational history with a high index of clinical suspicion is required to not miss this toxic etiology for movement disorders like ataxia, tremor, or myoclonus. In this review, we have discussed the past and present global health impact of Hg from a movement disorder perspective. The connection of Hg with neurodegeneration and autoimmunity has been highlighted. We have also discussed the role of chelating agents and the preventive strategies to combat the neurotoxic effects of Hg in the modern world.

show abstract

“…Mercury when bio-accumulated in the body system through various environmental sources produces several disease conditions in the body ( Guzzi et al., 2020 ). It has toxic effects on the reproductive, digestive, neurological and immune systems of the body ( Boujbiha et al., 2012 ; Oliveira et al., 2020a , b ; Lu and Khera, 2020 ; Mergler et al., 2007 ). Lead causes morphological, physiological and biochemical alterations in various organ systems of the human body ( Cassleman et al., 2020 ; AL-Megrin et al., 2020 ; Abdelhamid et al., 2020 ; Abdel Moneim, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Ethanol leaf extract of Psychotria microphylla rich in quercetin restores heavy metal induced redox imbalance in rats

Orji

Awoke

Harbor

et al. 2020

Heliyon

View full text Add to dashboard Cite

Psychotria microphylla is a plant found in Africa and many parts of the world where the leaves are locally used in folk medicine for the treatment of toxicity related liver diseases. We investigated the antioxidant potentials of ethanol leaf extract of Psychotria microphylla (ELE-PM) in restoring hepatic redox dysregulations in rats exposed to heavy metals. HPLC was used in quantifying the bioactive compounds in ELE-PM. DPPH (1,1-diphenyl-2 picrylhydrazyl), FRAP (Ferric reducing antioxidant power) and NO (Nitric Oxide) assays were used for in vitro studies. The in vivo studies involved 30 rats randomly divided into 5 groups ( n = 6). Group 1 received normal saline (2 mg/kg), group 2, 3, 4 and 5 received a combined solution of Pb(NO 3 ) 2 (11.25 mg/kg) and HgCl 2 (0.4 mg/kg) respectively. After 7 days of heavy metal exposure, groups 3, 4 and 5 received a daily bolus administration of 200, 400 and 600 mg/kg body weight of EE-PM respectively through oral intubation for 28 days. HPLC quantification revealed a high amount of quercetin (27.43 ± 0.04 mg/100g), lower amounts of gallic acid (7.60 ± 0.06 mg/100g) and rutin (0.38 ± 0.009 mg/100g). Additionally, ELE-PM demonstrated strong inhibitory potentials against free radical scavenging activity generated in vitro . More interestingly, administration of ELE-PM significantly ameliorated hepatic redox dysregulations elicited by the exposure of the rats to heavy metals in a dose dependent pattern. ELE-PM is highly rich in flavonoid compound quercetin and perhaps this may be responsible for the strong antioxidant potentials exhibited in this investigation.

show abstract

Autoimmune Manifestations of Acute Mercury Toxicity

Cited by 4 publications

References 9 publications

Mercury Induced Autoimmunity: A Case of CASPR2/LGI1 Autoimmune Encephalitis in a 14-Month-old

Mercury Induced Autoimmunity: A Case of CASPR2/LGI1 Autoimmune Encephalitis in a 14-Month-old

Mercury and Movement Disorders: The Toxic Legacy Continues

Ethanol leaf extract of Psychotria microphylla rich in quercetin restores heavy metal induced redox imbalance in rats

Contact Info

Product

Resources

About