Autoimmune/inflammatory syndrome (ASIA) induced by biomaterials injection other than silicone medical grade

Alijotas‐Reig, Jaume; Garcia-Gimenez, Victor; Llurba, Elisa; Vilardell‐Tarrés, Miquel

doi:10.1177/0961203312458838

Cited by 31 publications

(40 citation statements)

References 30 publications

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“…Alijotas-Reig et al observed that 15 out of 185 cases (8%) of patients suffering from inflammatory/autoimmune disorders related to bioimplant injections had systemic or distant and multiple complaints that could be categorized as ASIA. SS was diagnosed in two patients representing a rather infrequent yet possible manifestation following a chronic stimulation from biomaterials used as fillers [ 89 ], an evidence reinforced by a further 3 cases published later on [ 90 ]. Thus, the epidemiology and pathomechanisms possibly linking some agents acting as adjuvants such as vaccines, silica, silicone implants and other biomaterials with SS are yet to be clarified.…”

Section: Classical Examples Of the Asia Syndromementioning

confidence: 99%

Classical Examples of the Concept of the ASIA Syndrome

et al. 2020

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Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) was first introduced in 2011 by Shoenfeld et al. and encompasses a cluster of related immune mediated diseases, which develop among genetically prone individuals as a result of adjuvant agent exposure. Since the recognition of ASIA syndrome, more than 4400 documented cases have been reported so far, illustrated by heterogeneous clinical manifestations and severity. In this review, five enigmatic conditions, including sarcoidosis, Sjögren’s syndrome, undifferentiated connective tissue disease, silicone implant incompatibility syndrome (SIIS), and immune-related adverse events (irAEs), are defined as classical examples of ASIA. Certainly, these disorders have been described after an adjuvant stimulus (silicone implantation, drugs, infections, metals, vaccines, etc.) among genetically predisposed individuals (mainly the HLA-DRB1 and PTPN22 gene), which induce an hyperstimulation of the immune system resulting in the production of autoantibodies, eventually leading to the development of autoimmune diseases. Circulating autonomic autoantibodies in the sera of patients with silicone breast implants, as well as anatomopathological aspects of small fiber neuropathy in their skin biopsies have been recently described. To our knowledge, these novel insights serve as a common explanation to the non-specific clinical manifestations reported in patients with ASIA, leading to the redefinition of the ASIA syndrome diagnostic criteria.

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Section: Classical Examples Of the Asia Syndromementioning

confidence: 99%

Classical Examples of the Concept of the ASIA Syndrome

et al. 2020

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“…5 These clinical and laboratory features related to exposure to diverse external stimuli were also studied by Shoenfeld and were identified as 'ASIA' or autoimmune/inflammatory syndrome induced by adjuvants. 6,7 So fillers can induce not only autoimmunity, but also, in a few cases, welldefined autoimmune diseases like, in our case, SLE. Considering the increasing use of fillers in general and PAI in particular, physicians should be aware of the risks of this potentially important clinical problem.…”

mentioning

confidence: 73%

A case of systemic lupus erythematosus following polyalkylimide dermal filler

Haber

Stephan

2015

Acad Dermatol Venereol

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“…There may be some debate as to whether any silicone-related reaction is always an acquired entity or whether some may have crossreactive or direct immune reactions that are stimulated after non-specific polyclonal activation for other reasons. Whereas silicone has drawn much attention in the ASIA context, various non-silicone adjuvants have also been associated with similar immune activations [61][62][63][64][65][66][67][68]. These include in the least acrylates, hyaluronic acid derivatives, acrylamides, poly-L-lactic acid, dental amalgams, various skin fillers, and vaccine components.…”

Section: Autoimmune/inflammatory Syndrome Induced By Adjuvantsmentioning

confidence: 99%

“…The clinical symptoms and signs of ASIA are considerably diverse (Tables 1, 2, and 3) [6,7,50,52,66,68,[71][72][73][74][75]. Most of the information in this regard is borrowed from the experience of ASIA and breast implants, although the clinical data relating to other foreign body materials is expanding.…”

Section: Autoimmune/inflammatory Syndrome Induced By Adjuvantsmentioning

confidence: 99%

Mast Cell Biology and Linkages for Non-clonal Mast Cell Activation and Autoimmune/Inflammatory Syndrome Induced by Adjuvants

Cimolai

2020

SN Compr. Clin. Med.

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Non-clonal mast cell activation disorder (syndrome) (NC-MCAD) and autoimmune/inflammatory syndrome induced by adjuvants (ASIA) are complex syndromic and spectral clinical entities which have contemporaneously garnered considerable attention and rightfully so. NC-MCAD presents with a predominantly allergic profile, and causative clinical variables may or may not be identified. Manifest NC-MCAD illnesses can be complex and involve several organ systems. Such diversity may be in part explained by the ubiquity and plasticity of the mast cell. ASIA, due to its broad definition, continues to expand as a clinical entity, especially with the greater recognition of what might constitute adjuvancy. Such diversity has the potential to overly stretch the boundaries for scientific investigation. For both NC-MCAD and ASIA, the inciting molecular mechanisms require elucidation. Future research would benefit from greater precision for clinical diagnosis and risk factor identification, and the latter would be potentially facilitated by the discovery of reliable laboratory markers. Some patients with ASIA may present with clinical features that may be identified as NC-MCAD. This review examines the potential spectral nexus of NC-MCAD and ASIA and considers the role of the mast cell in such a possible interface.

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Autoimmune/inflammatory syndrome (ASIA) induced by biomaterials injection other than silicone medical grade

Abstract: Infrequently, biomaterials other than silicone can provoke local inflammatory adverse reactions that may evolve into systemic autoimmune and/or granulomatous disorders. Whether or not these biomaterials act as an adjuvant, they could be included in the ASIA category.

Cited by 31 publications

References 30 publications

Classical Examples of the Concept of the ASIA Syndrome

Classical Examples of the Concept of the ASIA Syndrome

A case of systemic lupus erythematosus following polyalkylimide dermal filler

Mast Cell Biology and Linkages for Non-clonal Mast Cell Activation and Autoimmune/Inflammatory Syndrome Induced by Adjuvants

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