Autoimmune hepatitis (<scp>AIH</scp>) following coronavirus (<scp>COVID</scp>‐19) vaccine—No longer exclusive to <scp>mRNA</scp> vaccine?

Shahrani, Shahreedhan; Yeong, Sooi Choong; Hilmi, Ida; Mahadeva, Sanjiv

doi:10.1111/liv.15350

Cited by 12 publications

(3 citation statements)

References 5 publications

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“…However, both conditions have also been reported in AIH [ 141 , 142 ]. To date, COVID-19 vaccines that induce AIH include mRNA vaccines, viral vector vaccines, and inactivated vaccines, with mRNA vaccines accounting for the majority and inactivated vaccines accounting for the least [ 15 , 140 , [143] , [144] , [145] , [146] , [147] , [148] , [149] , [150] , [151] , [152] , [153] , [154] , [155] , [156] , [157] , [158] , [159] , [160] , [161] , [162] , [163] , [164] , [165] , [166] , [167] , [168] ]. Clayton-Chubb et al reported for the first time a case of adenovirus-based vaccine eliciting AIH.…”

Section: Resultsmentioning

confidence: 99%

Insights into new-onset autoimmune diseases after COVID-19 vaccination

Guo

Liu

Chen

et al. 2023

Autoimmunity Reviews

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Section: Resultsmentioning

confidence: 99%

Insights into new-onset autoimmune diseases after COVID-19 vaccination

Guo

Liu

Chen

et al. 2023

Autoimmunity Reviews

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“…A total of 39 cases of COVID-19 vaccine-associated AIH syndromes were collected from databases [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ]. The median age of diagnosis was 59.0 years, with 24 (61.5%) patients over 50 years old.…”

Section: Characteristics Of Patients With Vaccine-associated Aih Befo...mentioning

confidence: 99%

“…Case reports started to appear in 2021, and 39 patients with AIH-like syndromes have been reported thus far [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ] (see Supplementary Materials ). Autoimmune hepatitis, described by Waldenström in 1951, is a progressive inflammatory liver disease that may lead to cirrhosis, hepatocellular carcinoma, liver transplantation, and even death [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical Features of COVID-19 Vaccine-Associated Autoimmune Hepatitis: A Systematic Review

Zhou

2023

Diseases

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Autoimmune hepatitis (AIH) is an inflammatory liver disease wherein the body’s immune system instigates an attack on the liver, causing inflammation and hepatic impairment. This disease usually manifests in genetically predisposed individuals and is triggered by stimuli or environments such as viral infections, environmental toxins, and drugs. The causal role of COVID-19 vaccination in AIH remains uncertain. This review of 39 cases of vaccine-related AIH indicates that female patients above the age of 50 years or those with potential AIH risk factors may be susceptible to vaccine-related AIH, and the clinical features of vaccine-associated AIH are similar to those of idiopathic AIH. These features commonly manifest in patients after the first dose of vaccination, with symptom onset typically delayed by 10–14 days. The incidence of underlying liver disease in patients with potential health conditions associated to liver disease is similar to that of patients without preexisting illnesses. Steroid administration is effective in treating vaccine-related AIH-susceptible patients, with most patients experiencing improvement in their clinical symptoms. However, care should be taken to prevent bacterial infections during drug administration. Furthermore, the possible pathogenic mechanisms of vaccine-associated AIH are discussed to offer potential ideas for vaccine development and enhancement. Although the incidence of vaccine-related AIH is rare, individuals should not be deterred from receiving the COVID-19 vaccine, as the benefits of vaccination significantly outweigh the risks.

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AZD 1222/SARS COV-2 vaccine inactivated Sinovac Biotech/tozinameran

2022

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Autoimmune hepatitis (AIH) following coronavirus (COVID‐19) vaccine—No longer exclusive to mRNA vaccine?

Cited by 12 publications

References 5 publications

Insights into new-onset autoimmune diseases after COVID-19 vaccination

Insights into new-onset autoimmune diseases after COVID-19 vaccination

Clinical Features of COVID-19 Vaccine-Associated Autoimmune Hepatitis: A Systematic Review

AZD 1222/SARS COV-2 vaccine inactivated Sinovac Biotech/tozinameran

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