Autoimmune Hepatitis Overlapping with Primary Sclerosing Cholangitis.

Primary Sclerosing Cholangitis and Autoimmune Hepatitis Overlapping Syndrome Complicated by Ulcerative Colitis

“…PSC-AIH overlap syndrome (PSC-AIH OS) is a rare disease characterized by the biochemical and histological features of AIH and the cholangiography abnormalities found in PSC. However, there have been few reports of AIH-PSC OS in Japan (3,4). We herein report a case of PSC-AIH OS complicated by ulcerative colitis (UC).…”

Long-term, low-dose immunosuppression for myasthenia does not affect collateral, asymptomatic sclerosing cholangitis

“…Low-dose AZT has a sufficient therapeutic effect on MG without deterioration of PSC. Possibly, AZT was beneficial even for PSC, since the patient exclusively required ursodesoxycholic acid, PSC did not progress so far, and AZT has also been recommended as a treatment of PSC 5 . Immunosuppressive agents other than AZT were considered, but they were rejected because AZT is the only approved immunosuppressive drug for MG and since other agents are potentially liver-toxic as well.…”

“…Immunosuppressive agents other than AZT were considered, but they were rejected because AZT is the only approved immunosuppressive drug for MG and since other agents are potentially liver-toxic as well. Continuation of steroids was also considered since they may have a beneficial effect on PSC 5 and on MG, but they were lastly stopped for their side effects, their ineffectivity on the AchR-antibody titers, and since PSC did not deteriorate after their discontinuation.…”

Primary Sclerosing Cholangitis

“…These patients likely have a more favorable long-term prognosis in terms of survival with low rates of progression to large duct PSC [126]. PSC has also been described as an "overlap" syndrome with autoimmune hepatitis [115,127,128].…”