Autoimmune hepatitis in adult and pediatric patients: Is there any difference?

Chong, Vui Heng; Jalihal, Anand; Telisinghe, Pemasari Upali

doi:10.1007/s12664-015-0564-5

Cited by 3 publications

(13 citation statements)

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“…[26][27][28] Sixteen studies reporting AIH prevalence rates were included, with nine from Europe, 6,7,9,11,12,20,21,23,24 two from America, 4,29 and five from Asia. 3,5,8,10,30 The characteristics of these studies are summarized in Table 2. In addition, five eligible studies were available to calculate the genderspecific incidence 5,11,23,26,27 and 10 for gender-specific prevalence.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, five eligible studies were available to calculate the genderspecific incidence 5,11,23,26,27 and 10 for gender-specific prevalence. [3][4][5][6][7][8]12,23,29,30 Study quality. Results of quality assessment for included studies are listed in Tables 1 and 2.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 17 studies reporting the incidence of AIH and the study characteristics are shown in Table , with 11 from Europe, three from Asia, and three from America . Sixteen studies reporting AIH prevalence rates were included, with nine from Europe, two from America, and five from Asia . The characteristics of these studies are summarized in Table .…”

Section: Resultsmentioning

confidence: 99%

“…As an example, the crude prevalence rate of AIH in New Zealand is 24.5 per 100 000 persons; after standardizing to the WHO population, the prevalence rate changes to 18.9 per 100 000 persons . As another example, studies conducted only in pediatric population might underestimate the epidemiological results of AIH, because adults are more vulnerable to develop or presently suffer from AIH . Therefore, the pooled incidence rate in American might be underestimated because two of the three studies from America were conducted in pediatric population.…”

Section: Discussionmentioning

confidence: 99%

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Systematic review and meta‐analysis on the incidence and prevalence of autoimmune hepatitis in Asian, European, and American population

Zeng

et al. 2019

J of Gastro and Hepatol

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Background and Aim Reported incidence and prevalence rates of autoimmune hepatitis (AIH) have been sparse and heterogeneous. The aim of this meta‐analysis was to estimate the worldwide incidence and prevalence rates of AIH and reveal population difference. Methods Published articles on the epidemiology of AIH in PubMed, Embase, and Cochrane Library were systematically searched from inception to April 28, 2019. Two investigators independently reviewed these literatures and evaluated their quality. A random‐effects model was used to pool the overall incidence and prevalence rates. The impact of population difference, gender, age, study period, study quality, diagnostic criteria, and study design was further analyzed with subgroup analysis and meta‐regression. Results A total of 22 studies were included in the meta‐analysis. The pooled worldwide annual incidence and prevalence of AIH were 1.37 (95% confidence interval [CI]: 0.95–1.80) and 17.44 (95% CI: 12.01–22.87) per 100 000 persons, respectively. Subgroup analysis showed that the pooled annual incidence for Asian, European, and American population was 1.31 (95% CI: 0.42–2.20), 1.37 (95% CI: 1.10–1.64), and 1.00 (95% CI: 0.44–1.56) per 100 000 persons, respectively; the pooled prevalence for Asian, European, and American population was 12.99 (95% CI: 2.05–23.92), 19.44 (95% CI: 15.63–23.24), and 22.80 (95% CI: −13.48 to 59.07) per 100 000 persons, respectively. In addition, higher incidence and prevalence rates were observed in women than men, and a higher prevalence rate was observed in elderly than young people. Conclusions Autoimmune hepatitis is a rare disease, with a similar incidence worldwide and a higher prevalence in European and American than in Asian population.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Systematic review and meta‐analysis on the incidence and prevalence of autoimmune hepatitis in Asian, European, and American population

Zeng

et al. 2019

J of Gastro and Hepatol

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“…новки диагноза от 36 до 78% детей уже имеют цирроз печени [8][9][10]. Легкие формы аутоиммунных заболеваний печени, описанные у взрослых, редко встречаются у молодых пациентов [11].…”

Section: Introductionunclassified

Contemporary Methods of Treating Children with Autoimmune Nephric Diseases

Владимировна¹,

Shumilov²

2016

Pediatr. farmakol.

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Российский национальный исследовательский медицинский университет им. Н.И. Пирогова, Москва, Российская Федерация В обзоре проанализированы современные схемы терапии и их эффективность у детей с аутоиммунными заболеваниями печени. Описаны особенности применения стандартного режима терапии у детей, рассмотрены альтернативные схемы лечения с использованием циклоспорина, такролимуса, будесонида и урсодезоксихолевой кислоты, а также необходимость применения препаратов второй линии для лечения больных с резистентными случаями аутоиммунных заболеваний печени. Освещены перспективные направления лечения этой категории больных. Ключевые слова: дети, аутоиммунные заболевания печени, аутоиммунный гепатит, аутоиммунный склерозирующий холангит, лечение.

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