Autoimmune hepatitis and pregnancy

Braga, António; Vasconcelos, Carlos; Braga, J. P.

doi:10.1016/j.bpobgyn.2020.03.007

Cited by 11 publications

(9 citation statements)

References 40 publications

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“…This was consistent with the findings of Huang et al [19], who reported that in comparison to the general population, there is an increased risk of fetal death among women with cirrhosis (0.7% vs. 2.8% respectively). In contrast, both Stokkeland et al [9] and Braga et al [8] found that there was no statistically significant association between AIH and stillbirth or neonatal mortality. However, these studies did not comment on the proportion of cirrhosis in their participants.…”

Section: Discussionmentioning

confidence: 90%

“…inflammation and necrosis that can result in hepatic cirrhosis [8]. Autoimmune hepatitis is reported to be more common in women, especially during their childbearing years.…”

Section: Case Report Peer Reviewed | Open Accessmentioning

confidence: 99%

“…Autoimmune hepatitis is reported to be more common in women, especially during their childbearing years. While most autoimmune disorders are better controlled during pregnancy due to a state of immune tolerance, some women experience severe flares of AIH [8]. Prednisolone and Azathioprine are the treatments of choice during pregnancy to treat and prevent flares [9,10].…”

Section: Case Report Peer Reviewed | Open Accessmentioning

confidence: 99%

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Hepatic cirrhosis with portal hypertension secondary to alpha-1 antitrypsin deficiency and autoimmune hepatitis in pregnancy: A case report

Galibert

O’Rourke

Wolski

et al. 2022

J Case Rep Images Obstet Gynecol

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Introduction: Previously, women with cirrhosis rarely became pregnant due to hypothalamic-pituitary dysfunction. However, with advancements in the care of patients with chronic liver disease, pregnancy is becoming more common in this cohort. We will outline the complex, multidisciplinary approach toward managing an obstetrics patient with portal hypertension in the context of previously decompensated liver cirrhosis. Case Report: A 29-year-old primigravida woman was referred to the Obstetric Medicine Clinic with an unplanned pregnancy at 16 weeks’ gestation. This was on a background of previously decompensated liver cirrhosis and portal hypertension, in the context of alpha-1 antitrypsin deficiency and autoimmune hepatitis. The patient had one upper gastrointestinal bleed at 19 weeks’ gestation and underwent three gastroscopies throughout her pregnancy. At 32+6 weeks gestation, she had an elective lower uterine segment Caesarean Section and delivered a healthy liveborn female. Conclusion: Currently, there are no studies that explore pregnancy outcomes in women with cirrhosis secondary to alpha-1 antitrypsin deficiency. This case describes the pregnancy of a woman with previously decompensated liver cirrhosis and portal hypertension, in the context of alpha-1 antitrypsin deficiency and explores the associated management dilemmas.

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Section: Discussionmentioning

confidence: 90%

“…inflammation and necrosis that can result in hepatic cirrhosis [8]. Autoimmune hepatitis is reported to be more common in women, especially during their childbearing years.…”

Section: Case Report Peer Reviewed | Open Accessmentioning

confidence: 99%

Section: Case Report Peer Reviewed | Open Accessmentioning

confidence: 99%

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Hepatic cirrhosis with portal hypertension secondary to alpha-1 antitrypsin deficiency and autoimmune hepatitis in pregnancy: A case report

Galibert

O’Rourke

Wolski

et al. 2022

J Case Rep Images Obstet Gynecol

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“…AIH may occur in patients undergoing liver transplantation due to different diseases. De novo AIH after transplantation may be caused by an immune response to an allogeneic antigen that triggers an autoimmune response[ 41 , 42 ]. Recurrent AIH is associated with elevated liver enzymes and IgG before liver transplantation, lymphoplasmacytic infiltration and steroid deficiency after liver transplantation[ 43 , 44 ].…”

Section: Pregnancy and Liver Transplantionmentioning

confidence: 99%

“…The pathogenesis of recurrent or de novo AIH after liver transplantation is unclear, and may be related to factors such as transplanted organs and immunosuppressive drug treatment. Early rapid diagnosis can avoid strong rejection and possible secondary liver transplantation[ 41 - 43 ].…”

Section: Pregnancy and Liver Transplantionmentioning

confidence: 99%

Pathogenesis of autoimmune hepatitis

Fan¹,

Liu²,

Lv³

et al. 2021

WJH

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Autoimmune hepatitis (AIH) is a chronic progressive liver disease whose etiology and pathogenesis are not yet clear. It is currently believed that the occurrence of AIH is closely related to genetic susceptibility and immune abnormalities, and other factors such as environment, viral infection and drugs that may cause immune dysfunction. This article reviews the pathogenesis of AIH and describes the latest research results in the past 5 years.

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Pregnancy and Liver Disease

Miller

Westbrook

2022

In Clinical Practice

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Autoimmune hepatitis and pregnancy

Cited by 11 publications

References 40 publications

Hepatic cirrhosis with portal hypertension secondary to alpha-1 antitrypsin deficiency and autoimmune hepatitis in pregnancy: A case report

Hepatic cirrhosis with portal hypertension secondary to alpha-1 antitrypsin deficiency and autoimmune hepatitis in pregnancy: A case report

Pathogenesis of autoimmune hepatitis

Pregnancy and Liver Disease

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