2021
DOI: 10.29328/journal.jhcr.1001016
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Autoimmune hemolytic anemia in COVID-19 patients, the « transmissible » direct Coombs test

Abstract: Background: Like other viruses, the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) appears to be responsible for several autoimmune complications. The occurrence of autoimmune hemolytic anemia has been described in several case reports. This AIHA was also noticeable by the important number of blood transfusions required for COVID-19 (coronavirus disease 2019) patients. By investigating RBC coating autoantibodies, this article attempts to clarify the autoimmune aspect of the anemia in the context … Show more

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Cited by 8 publications
(7 citation statements)
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“…The exact mechanism of AIHA in the setting of COVID-19 infection remains unknown. One proposed mechanism is that the SARS-CoV-2 cytokine-rich inflammatory environment causes alteration in antigen presentation creating cryptic antigens [ 21 ]. Those cryptic antigens stimulate T lymphocytes which in turn activates autoreactive B lymphocytes to produce antibodies against those antigens [ 21 - 23 ].…”
Section: Discussionmentioning
confidence: 99%
See 4 more Smart Citations
“…The exact mechanism of AIHA in the setting of COVID-19 infection remains unknown. One proposed mechanism is that the SARS-CoV-2 cytokine-rich inflammatory environment causes alteration in antigen presentation creating cryptic antigens [ 21 ]. Those cryptic antigens stimulate T lymphocytes which in turn activates autoreactive B lymphocytes to produce antibodies against those antigens [ 21 - 23 ].…”
Section: Discussionmentioning
confidence: 99%
“…One proposed mechanism is that the SARS-CoV-2 cytokine-rich inflammatory environment causes alteration in antigen presentation creating cryptic antigens [ 21 ]. Those cryptic antigens stimulate T lymphocytes which in turn activates autoreactive B lymphocytes to produce antibodies against those antigens [ 21 - 23 ]. These antibodies then coat the red blood cells (RBCs) causing the positive DAT in around 44-46% of COVID-19 patients [ 21 , 24 ].…”
Section: Discussionmentioning
confidence: 99%
See 3 more Smart Citations