Autoimmune Hemolytic Anemia Following MF59-Adjuvanted Influenza Vaccine Administration: A Report of Two Cases

Montagnani, Sabrina; Tuccori, Marco; Lombardo, Giuseppe; Testi, Arianna; Mantarro, Stefania; Ruggiero, Elisa; Blandizzi, Corrado

doi:10.1345/aph.1p480

Cited by 19 publications

(20 citation statements)

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“…More recently, authors have reported both positive and negative effects of squalene on the immune system. Whereas Escrich and others (2011) have hypothesized that the chemopreventive effect of extra virgin olive oil on breast cancer may be due at least in part to squalene and phenolic antioxidants, Tritto and others (2009) and Montagnani and others (2011) have attributed an autoimmune reaction of some individuals to a squalene‐based adjuvant used in flu vaccines. Although a mechanism for the possible role of squalene on immunomodulation is not yet at reach, it is apparent that the lipid molecule can in fact influence the immune system most likely by altering the immune cell membrane.…”

Section: Immune System Influencementioning

confidence: 99%

State of Knowledge on Amaranth Grain: A Comprehensive Review

Caselato-Sousa

Amaya-Farfán

2012

Journal of Food Science

211

118

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Amaranth grain is a highly nutritional pseudocereal with a superior amount of proteins when compared to true cereals. It is a reasonably well-balanced food with functional properties that have been shown to provide medicinal benefits. The health benefits attributed include decreasing plasma cholesterol levels, stimulating the immune system, exerting an antitumor activity, reducing blood glucose levels and improving conditions of hypertension and anemia. In addition, it has been reported to possess anti-allergic and antioxidant activities. The present article provides a comprehensive overview of amaranth grain that focuses on recent research reporting its use in the clinical practice and its possible benefits to human health.

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Section: Immune System Influencementioning

confidence: 99%

State of Knowledge on Amaranth Grain: A Comprehensive Review

Caselato-Sousa

Amaya-Farfán

2012

Journal of Food Science

211

118

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“…Her anemia improved within two weeks after the administration of steroids and immunoglobulin. (4) Montagnani et al [30] reported the case of a 74-year-old woman with aortic valvulopathy who developed Coombs-positive AIHA approximately three days after the administration of influenza vaccine. She died two days later after being hospitalized despite reduced anemia induced by treatment (corticosteroids and transfusion).…”

Section: Aiha Associated With Viral Infectionsmentioning

confidence: 99%

“…Although the mechanism of pathogenesis of autoimmune disorders induced by the administration of influenza vaccine is unknown, one possibility is the induction of an autoimmune response by molecular mimicry of host antigens by viral-derived peptides that induce crossactivation of autoreactive T or B cells [30]. The etiopathogenesis of autoimmune disorders induced by influenza vaccine remains unclear.…”

Section: Aiha Cases Followed By Administration Of Influenza Vaccinementioning

confidence: 99%

“…The etiopathogenesis of autoimmune disorders induced by influenza vaccine remains unclear. However, mechanism-induce autoimmune responses may elicit crossactivation of autoreactive T or B cells [30].…”

Section: Aiha Cases Followed By Administration Of Influenza Vaccinementioning

confidence: 99%

“…There are five reports [5,[30][31][32] in the English literature of AIHA that occurred several days after influenza vaccination (including cases of Evans syndrome), suggesting that the vaccinations may be the cause. The reports are as follows: (1) Tsuchiya et al [31] reported the case of a 9-year-old boy who developed Coombs-negative AIHA five days after two influenza vaccinations.…”

Section: Aiha Cases Followed By Administration Of Influenza Vaccinementioning

confidence: 99%

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Autoimmune Hemolytic Anemia Following Influenza Virus Infection or Administration of Influenza Vaccine

Shizuma¹

2014

J Blood Disord Transfus

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Autoimmune hemolytic anemia (AIHA) is caused by hemolysis induced by the reaction of autoantibodies with red blood cells. AIHA is categorized as warm, cold, and mixed types and as primary or secondary. Certain viral infections lead to secondary AIHA; however, AIHA induced by influenza virus infection or the administration of influenza vaccine is infrequent. Here, we review relevant case reports in the English and Japanese literature.

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Analysis of hematologic adverse events reported to a national surveillance system following COVID-19 bivalent booster vaccination

2023

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Hematologic complications, including vaccine-induced immune thrombotic thrombocytopenia (VITT), immune thrombocytopenia (ITP), and autoimmune hemolytic anemia (AIHA), have been associated with the original severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines. However, on August 31, 2022, new formulations of the Pfizer-BioNTech and Moderna vaccines were approved for use without clinical trial testing. Thus, any potential adverse hematologic effects with these new vaccines remain unknown. We queried the US Centers for Disease Control Vaccine Adverse Event Reporting System (VAERS), a national surveillance database, through February 3, 2023, all reported hematologic adverse events that occurred within 42 days of administration of either the Pfizer-BioNTech or Moderna Bivalent COVID-19 Booster vaccine. We included all patient ages and geographic locations and utilized 71 unique VAERS diagnostic codes pertaining to a hematologic condition as defined in the VAERS database. Fifty-five reports of hematologic events were identified (60.0% Pfizer-BioNTech, 27.3% Moderna, 7.3% Pfizer-BioNTech bivalent booster plus influenza, 5.5% Moderna bivalent booster plus influenza). The median age of patients was 66 years, and 90.9% (50/55) of reports involved a description of cytopenias or thrombosis. Notably, 3 potential cases of ITP and 1 case of VITT were identified. In one of the first safety analyses of the new SARS-CoV-2 booster vaccines, we identified few adverse hematologic events (1.05 per 1,000,000 doses), most of which could not be definitively attributed to vaccination. However, three reports of possible ITP and one report of possible VITT highlight the need for continued safety monitoring of these vaccines as their use expands and new formulations are authorized. KeywordsCOVID-19 • SARS-CoV-2 • Bivalent vaccine • Autoimmune hemolytic anemia • Immune thrombocytopenia • Vaccine-induced immune thrombotic thrombocytopenia * Jeremy W. Jacobs

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Autoimmune Hemolytic Anemia Following MF59-Adjuvanted Influenza Vaccine Administration: A Report of Two Cases

Cited by 19 publications

References 0 publications

State of Knowledge on Amaranth Grain: A Comprehensive Review

State of Knowledge on Amaranth Grain: A Comprehensive Review

Autoimmune Hemolytic Anemia Following Influenza Virus Infection or Administration of Influenza Vaccine

Analysis of hematologic adverse events reported to a national surveillance system following COVID-19 bivalent booster vaccination

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