Autoimmune hemolytic anemia as a presenting manifestation of Hodgkin disease

Chu, Jhih‐Wei; McElfresh, Arthur E.; Waeltermann, Robert M.

doi:10.1016/s0022-3476(76)80542-2

Cited by 22 publications

(7 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This was also found by others [6,13]. It is noteworthy that the number of patients with malignant disease is fairly high, unlike May and Bryan [9] and Chu et al [4], who are of the opinion that AIHA is rarely associated with malignant disease in chil dren.…”

Section: Discussionsupporting

confidence: 61%

Auto-Immune Haemolytic Anaemia in Childhood

Luca¹,

Casadei²,

Piero³

et al. 1979

Vox Sanguinis

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 61%

Auto-Immune Haemolytic Anaemia in Childhood

Luca¹,

Casadei²,

Piero³

et al. 1979

Vox Sanguinis

View full text Add to dashboard Cite

show abstract

“…In other series, AIH secondary to underlying chronic disorders made up a much higher proportion of cases, and im mune deficiency, collagen or lymphoproliferative diseases were seen in up to near ly 40% of patients [4,[6][7][8][9][10]. The well-recognised association in children of AIH and Hodgkin's disease [10,[14][15][16][17] or giant cell hepatitis [18] was not seen in the pres ent study.…”

Section: Association With Other Disordersmentioning

confidence: 76%

Autoimmune Haemolysis in Childhood and Adolescence

et al. 1984

View full text Add to dashboard Cite

The clinico-pathological features of 42 children with autoimmune haemolysis are described. Over 65 % of cases were seen before their 5th birthday. In this group males predominated by the ratio of 2.5:1, but in the older children both sexes were equally affected. The incidence decreased from 1 in 188 × 10³ in young males to 1 in 1,780 × 10³ in children over 10. Cases were classified serologically. Of particular note was the frequency of Donath-Landsteiner haemolysis which equalled that due to warm autoantibodies; together these groups made up 79% of the total cases. Most haemolytic episodes followed an acute infection. This was frequently mild and often involved the upper respiratory tract; in only 2 patients was haemolysis associated with underlying collagenosis. Typically there was a sudden onset of pallor and malaise; jaundice, splenomegaly and hepatomegaly were found in about half the subjects. Haemoglobinuria was characteristic of Donath-Landsteiner haemolysis. The illness was severe, with Hb levels falling below 6.0 g/dl in 28 patients. Prednisolone, blood transfusion and, where indicated, antibiotics were usually effective in treating the illness, with splenectomy reserved for cases where this treatment was unsatisfactory. In several individuals no treatment was required. Recovery was rapid, and complete recovery occurred in 83 % of patients, usually within 6 months. Although 2 patients died, a generally optimistic prognosis can be given, particularly in the absence of an underlying chronic disorder.

show abstract

“…18,19 The frequency of Coombs'-positive hemolytic anemia in children with Hodgkin's disease is probably lower, with only a few reported cases. [20][21][22][23][24] In contrast, an estimated 10 to 25 percent of patients with B-cell chronic lymphocytic leukemia have had autoimmune hemolytic anemia at some time during the course of the disease. 25 When Hodgkin's disease is accompanied by a Coombs'-positive autoimmune hemolytic anemia, the hemolysis is usually detected at the time of the diagnosis or a relapse, but it has been reported to precede the diagnosis by an interval of up to three years.…”

Section: Dr W Hallowell Churchill's Diagnosismentioning

confidence: 99%

“…The Coombs' test may be a marker of disease activity, becoming negative with definitive treatment and positive again before a relapse. 18,19,[21][22][23][24][25] However, no known association between a positive Coombs' test and a poor outcome has been demonstrated in patients with Hodgkin's disease. In fact, in one study, the Coombs' test often became negative in the terminal phase of the disease.…”

Section: Dr W Hallowell Churchill's Diagnosismentioning

confidence: 99%

Case 13-1997

Churchill¹,

Nguyen²

1997

N Engl J Med

View full text Add to dashboard Cite

A 32-year-old man was admitted to the hospital because of IgG antibody and Coombs'-positive hemolytic anemia resistant to corticosteroid treatment.The patient had been well until about five months earlier, when he began to have low-grade fever, night sweats, and nonpleuritic pain in the right deltoid region. Laboratory tests were performed at another hospital. The urea nitrogen, creatinine, glucose, total protein, ferritin, and lactate dehydrogenase levels were normal; the results of other tests are shown in Tables 1, 2, and 3. A radiograph of the chest was normal. Microscopical examination of an aspirated bone marrow specimen showed erythroid hyperplasia. A tuberculin skin test was negative, with positive controls. Prednisone (80 mg daily) was administered. The fever and sweats subsided, and the hematocrit rose to 25.5 percent.Two months before admission, the patient was seen at this hospital. Treatment with prednisone was continued. Several weeks before admission the hematocrit decreased to 18 percent. Five days before admission, a computed tomographic (CT) scan of the thorax (Fig. 1) showed bulky right axillary lymphadenopathy. A CT scan of the abdomen and pelvis (Fig. 2) revealed hepatosplenomegaly and lymphadenopathy, principally in the para-aortic, aortocaval, and right pelvic regions. A magnetic resonance imaging (MRI) examination of the right arm (Fig. 3) showed an abnormal signal in the medulla of the humerus, a finding consistent with regenerating marrow. Microscopical examination of an aspirated bone marrow specimen showed marked trilineage hematopoiesis. Microscopical examination of thick and thin blood smears showed no *To convert value to micromoles per liter, multiply by 0.1791.

show abstract

Autoimmune hemolytic anemia as a presenting manifestation of Hodgkin disease

Cited by 22 publications

References 3 publications

Auto-Immune Haemolytic Anaemia in Childhood

Auto-Immune Haemolytic Anaemia in Childhood

Autoimmune Haemolysis in Childhood and Adolescence

Case 13-1997

Contact Info

Product

Resources

About