Autoimmune hemolityc anemia concomitant with sequential autoimmune hepatitis-primary biliary cirrhosis overlap syndrome and Hashimoto’s thyroiditis: A new entity of autoimmune polyendocrine syndrome

Gentile, Massimo; Verta, Michael J.; Vigna, Ernesto; Lucia, Eugenio; Mazzone, Carla; Perugini, D.; Gentile, Carlo; Bisconte, Maria Grazia; Romeo, Francesco; Leo, Pasqualina De; Betterle, Corrado; Morabito, Fortunato

doi:10.1007/bf03346469

Cited by 6 publications

(2 citation statements)

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“…The association between PBC and warm autoimmune hemolytic anemia (wAIHA) is quite rare. To our knowledge, only 20 case reports have been described in the literature . Here we reported a case of PBC‐associated wAIHA.…”

Section: Introductionmentioning

confidence: 86%

Primary biliary cholangitis associated with warm autoimmune hemolytic anemia

González-Moreno

Martínez-Cabriales

Cruz-Moreno

et al. 2016

J of Digest Diseases

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There are many autoimmune diseases associated with primary biliary cholangitis (PBC), known as primary biliary cirrhosis; however, the association between PBC and warm autoimmune hemolytic anemia (wAIHA) has rarely been reported. It is documented that hemolysis is present in over 50% of the patients with chronic liver disease, regardless of the etiologies. Due to the clear and frequent relationship between PBC and many autoimmune diseases, it is reasonable to suppose that wAIHA may be another autoimmune disorder seen in association with PBC. Here we reported a 53-year-old female patient diagnosed with wAIHA associated with PBC.

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Section: Introductionmentioning

confidence: 86%

Primary biliary cholangitis associated with warm autoimmune hemolytic anemia

González-Moreno

Martínez-Cabriales

Cruz-Moreno

et al. 2016

J of Digest Diseases

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“…There are various reports of PBC–AIH overlap presenting with other autoimmune manifestations like concurrent Idiopathic Thrombocytopenic Purpura ITP and systemic sclerosis,[ 69 ] antiphospholipid syndrome,[ 70 ] concomitant ITP and Hashimoto's disease,[ 71 ] autoimmune hemolytic anemia,[ 72 ] and membranous glomerulonephritis,[ 73 ] which suggest the presence of shared genetic susceptibility factors in multiple autoimmune conditions.…”

Section: Aih–pbc Overlap Syndromementioning

confidence: 99%

Overlap syndromes: An emerging diagnostic and therapeutic challenge

Dhiman

Malhotra

2014

Saudi J Gastroenterol

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Overlap syndrome in hepatology is emerging as a diagnostic and therapeutic challenge, which is further complicated by the present gaps in the information regarding the immunopathogenesis of these diseases. The present review represents a concise review of literature on overlap syndromes with emphasis on prevalence, etiopathogenesis, clinical presentation, diagnosis, and management of true overlap syndromes.

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