Autoimmune Haemolytic Anaemia in Infancy with Anti‐Kp<sup>b</sup> Specificity

Win, Nay; Kaye, T.; Mir, Naheed; Damain-Willems, C.; Chatfield, Catherine

doi:10.1046/j.1423-0410.1996.7130187.x

Cited by 12 publications

(6 citation statements)

References 8 publications

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“…The possibility that blood transfusions may be associated with an increased risk of cancer recurrence and a higher incidence of postoperative bacterial infections has been widely discussed for two decades, although still without a clearcut conclusion [17, 18, 19]. Some evidence has been presented showing a lower incidence of postoperative bacterial complications when leukodepleted red cells are used [20].…”

Section: The Development Of Blood Component Therapymentioning

confidence: 99%

Liquid–Stored Red Blood Cells for Transfusion

Högman¹

1999

Vox Sanguinis

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Blood transfusion in a modern sense means the transfusion of red cells, when necessary supplemented by other components. The demand for plasma and plasma fractions and for platelets for therapeutic use has had an influence on the technique for preparing red cells. Automated devices have made it possible to perform collection as well as separation under more standardized conditions. Improved techniques for storage of red cells have prolonged the shelf life somewhat but most of the available methods disregard the rapid loss of 2,3–diphosphoglycerate and the accompanying increase in oxygen affinity. Methods are available which reduce the number of contaminating leukocytes to low levels, but information is still incomplete as to the degree of depletion actually needed.

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Section: The Development Of Blood Component Therapymentioning

confidence: 99%

Liquid–Stored Red Blood Cells for Transfusion

Högman¹

1999

Vox Sanguinis

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“…It has been speculated that some unknown blood-borne oncogenic viruses may be present [1, 2, 3, 4, 5]. Although allogeneic blood transfusions may have immunomodulatory effects, the precise mechanisms have not been elucidated [6, 7]. It has therefore also been speculated that some immunologic response to transfusion may favor a subsequent development of NHL [1, 2, 3, 4].…”

Section: Introductionmentioning

confidence: 99%

Blood Transfusion at Delivery and Risk of Subsequent Malignant Lymphoma in the Mother

Anderson¹,

Brandt

Ericson

et al. 1998

Vox Sanguinis

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Background and Objectives: Blood transfusion has been shown to be a risk factor for non-Hodgkin’s lymphoma (NHL). Materials and Methods: In a cohort of 77,928 women with bleeding complications at delivery in the period of 1973–1986, subsequent NHL cases were identified and the number was compared with the number expected from national incidence rates. In a case-control study the proportion of transfused NHL cases was compared with the proportion of transfused controls. Results: The observed number of NHL in the cohort was 18 versus 22.0 expected. Information on transfusion was obtained for 15 of the NHL cases and none (0%) was transfused versus 32 out of 136 controls (23%). Conclusions: Blood transfusion at delivery is not a risk factor for NHL. The immune tolerance induced by pregnancy may reduce the risk of NHL associated with the transfusion of allogeneic blood cells.

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“…4 Fetal anemia may be due to the immune destruction of erythroid progenitor cells that have reacted with maternal Kell antibodies 5 Although KEL1 is the most immunogenic of all the Kell antigens, other Kell antigens are also immunogens and have been reported to sensitize mothers and cause fetal anemia. [6][7][8] Kell surface antigens are expressed early during erythropoiesis as determined in two different cell culture systems and have been shown to be expressed ahead of many other blood group antigens. 9,10 There is, however, little information on the expression of XK, the K other protein component of the Kell blood group complex, and thus in this study we compare the onset of expression of Kell and XK in sorted human hematopoietic progenitor cells (HPCs) and in mouse progenitor cells of defined lineage.…”

mentioning

confidence: 99%

“…Anti‐K (anti‐KEL1) can cause fetal anemia by inhibiting the growth of erythroid progenitor cells 4 . Fetal anemia may be due to the immune destruction of erythroid progenitor cells that have reacted with maternal Kell antibodies 5 Although KEL1 is the most immunogenic of all the Kell antigens, other Kell antigens are also immunogens and have been reported to sensitize mothers and cause fetal anemia 6‐8 . Kell surface antigens are expressed early during erythropoiesis as determined in two different cell culture systems and have been shown to be expressed ahead of many other blood group antigens 9,10 .…”

mentioning

confidence: 99%