Autoimmune gastritis in autoimmune thyroid disease

Venerito, Marino; Radünz, Marcus; Reschke, Kirsten; Reinhold, Dirk; Frauenschläger, Katrin; Jechorek, Doerthe; Mario, F. Di; Malfertheiner, Peter

doi:10.1111/apt.13097

Cited by 38 publications

(32 citation statements)

References 36 publications

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“…In line with our previous report, we confirmed the presence of atrophy in the antrum in a subset (39%) of patients with AIG 11. It is of interest to note, that none of the patients with H. pylori -positive AIG had atrophy of the antrum, which however does not preclude the hypothesis that H. pylori infection might in some cases serve as trigger for AIG.…”

Section: Discussionsupporting

confidence: 92%

“…In patients with advanced OGA serum PG I levels are decreased whereas PG II levels are normal or may even be increased. Therefore, low serum PG I levels or a low ratio of PG I to PG II are used as surrogate markers for advanced OGA 11. In OGA the decreased gastric acidity results in loss of the negative pH control effect and consequent increased gastrin release from antral G cells.…”

Section: Introductionmentioning

confidence: 99%

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Oxyntic gastric atrophy inHelicobacter pylorigastritis is distinct from autoimmune gastritis

et al. 2016

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Oxyntic gastric atrophy inHelicobacter pylorigastritis is distinct from autoimmune gastritis

et al. 2016

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“…In a prospective study, the clinical, morphological, and serological phenotype of OGA in AIG was compared with OGA as a consequence of H. pylori infection in patients undergoing oesophagogastroduodenoscopy from July 2011 to October 2014 . Overall, OGA was diagnosed in 34/452 (22 women, age 61±15 years).…”

Section: Gastric Cancer: Screening For Preneoplastic Conditionsmentioning

confidence: 99%

Gastric cancer – clinical and epidemiological aspects

et al. 2016

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Gastric cancer (GC) ranks fifth for cancer incidence and second for cancer deaths. Epidemiological data showed that survivors of Hodgkin's lymphoma and patients with pernicious anemia etiologically linked to autoimmune gastritis are at increased risk of GC. Screening of patients with autoimmune thyroid disease by means of pepsinogen (PG) I and PG I/II detected autoimmune gastritis with oxyntic gastric atrophy in one of four patients and may be recommended for GC prevention purposes. The International Agency for Research on Cancer reported a positive association between consumption of processed meet and increased GC risk. A new GC risk prediction model based on biological markers, age, gender, smoking status, family history of GC, and consumption of highly salted food showed good predictive performance, and might prompt individuals to modify their lifestyle habits, attend regular check-up visits or participate in screening programs. A novel GC classification based on gene expression of primary resected cancers correlated with clinicopathological features. Noncoding RNA for GC screening remains the focus of multiple studies. Patients with early GC undergoing endoscopic resection are more likely to develop metachronous lesions than patients undergoing surgery and endoscopic surveillance is warranted in this special cohort. The addition of gastrectomy to chemotherapy did not improve survival of patients with advanced GC and a single noncurable factor. Apatinib, a novel oral vascular endothelial growth factor receptor 2 tyrosine kinase inhibitor, improved the median overall survival of patients with advanced GC and progressive disease after two or more lines of prior chemotherapy of nearly 3 months.

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“…Its prevalence, despite some difference of sex, age, race, and iodine intake, reaches about 5% in the general population (20). Much less frequent is the chronic autoimmune atrophic gastritis (type A gastritis or body/fundus gastritis), which represents only some 5% of the whole spectrum of chronic gastritis and must be differentiated from the one associated with chronic Helicobacter pylori (Hp) infection (type B gastritis or antral gastritis) (21, 22). HT is characterized by diffuse inflammatory changes with lymphocytic infiltration of the thyroid gland, leading to the destruction of the thyroid epithelial cells with subsequent fibrosis (23).…”

Section: Chronic Autoimmune/hashimoto’s Thyroiditis and Cagmentioning

confidence: 99%

“…The role of environmental factors in triggering autoimmune gastritis has been more studied and a stronger link between H. pylori infection and CAG has been detected, despite not sufficient to establish a causative relationship between these two diseases (21). H. pylori infection affects approximately 50% of the world population and is in turn the most common cause of chronic gastritis.…”

Section: Chronic Autoimmune/hashimoto’s Thyroiditis and Cagmentioning

confidence: 99%

Hashimoto’s Thyroiditis and Autoimmune Gastritis

Cellini¹,

Santaguida²,

Virili³

et al. 2017

Front. Endocrinol.

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The term “thyrogastric syndrome” defines the association between autoimmune thyroid disease and chronic autoimmune gastritis (CAG), and it was first described in the early 1960s. More recently, this association has been included in polyglandular autoimmune syndrome type IIIb, in which autoimmune thyroiditis represents the pivotal disorder. Hashimoto’s thyroiditis (HT) is the most frequent autoimmune disease, and it has been reported to be associated with gastric disorders in 10–40% of patients while about 40% of patients with autoimmune gastritis also present HT. Some intriguing similarities have been described about the pathogenic mechanism of these two disorders, involving a complex interaction among genetic, embryological, immunologic, and environmental factors. CAG is characterized by a partial or total disappearance of parietal cells implying the impairment of both hydrochloric acid and intrinsic factor production. The clinical outcome of this gastric damage is the occurrence of a hypochlorhydric-dependent iron-deficient anemia, followed by pernicious anemia concomitant with the progression to a severe gastric atrophy. Malabsorption of levothyroxine may occur as well. We have briefly summarized in this minireview the most recent achievements on this peculiar association of diseases that, in the last years, have been increasingly diagnosed.

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Autoimmune gastritis in autoimmune thyroid disease

Abstract: SUMMARY BackgroundAutoimmune gastritis leads to oxyntic gastric atrophy, a condition at increased risk for gastric cancer. Autoimmune gastritis in conjunction with autoimmune thyroid disease has been reported previously.

Cited by 38 publications

References 36 publications

Oxyntic gastric atrophy inHelicobacter pylorigastritis is distinct from autoimmune gastritis

Oxyntic gastric atrophy inHelicobacter pylorigastritis is distinct from autoimmune gastritis

Gastric cancer – clinical and epidemiological aspects

Hashimoto’s Thyroiditis and Autoimmune Gastritis

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