Autoimmune Disorders and Multiple Myeloma- Two Illustrative Case Reports and a Literature Review

Ávila, Ana María; Giralt, Sergío

doi:10.1016/j.rccan.2017.07.001

Cited by 3 publications

(2 citation statements)

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“…9 Several hypotheses have been proposed to explain the correlation; among them, the hyperreactivity of B lymphocytes, known in autoimmune diseases, predisposes some cell clones to escape the usual regulatory mechanisms. 12 And finally, it could be considered that condition compatible with SSc sine scleroderma present during MM exacerbations could just be a paraneoplastic syndrome. However, it is important to point out that the patient had a previous diagnosis of long-term limited SSc treated at another service.…”

Section: Discussionmentioning

confidence: 99%

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Critical digital ischaemia in systemic sclerosis exacerbated by multiple myeloma: A case report

Franco

Polho

Assad

et al. 2023

Journal of Scleroderma and Related Disorders

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Introduction: The overlapping of systemic sclerosis with hematologic malignancy has been described previously in the literature. This case report presents a patient with systemic sclerosis and multiple myeloma who had severe digital ischaemia that culminated in the amputation of several fingers. Case report: A 65-year-old White female patient was diagnosed with limited systemic sclerosis in 2002, smouldering multiple myeloma IgG/kappa in 2017 and liver cirrhosis in 2018 due to autoimmune hepatitis. In 2021, she was admitted to the emergency room with dry ischaemia of all fingers and toes despite optimized therapy, associated with visual blurring. The diagnostic hypothesis was hyperviscosity syndrome associated with multiple myeloma reactivation. The patient underwent chemotherapy and despite initial laboratory improvement, 19 digits required amputation. Conclusion: Although the association between systemic sclerosis and multiple myeloma is rare, it should be remembered in cases of significant worsening of Raynaud’s phenomenon. Causes unrelated to systemic sclerosis should also be considered in the presence of severe exacerbations in patients with other comorbidities.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%