Autoimmune Diseases of Digestive System

Vt, Ivashkinl; Sheptulina, A.F.; Kl, Raĭkhel'son; Ea, Losik; Kv, Ivashkin; Okhlobystin, Alexey; Ek, Baranskaia; Ea, Polouvektova; Os, Shifrin

doi:10.15690/vramn.v70i2.1306

Cited by 5 publications

(7 citation statements)

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“…Морфологически этот тип гастрита характеризуется выраженной атрофией фундальных желез с кишечной метаплазией. В детском возрасте атрофические формы гастрита имеют начальный характер с очаговой деструкцией фундальных желез, гиперплазией париетельных клеток, увеличением числа D и G клеток [51,[53][54][55].…”

Section: аутоиммунный гастрит связь с сахарным диабетом I типаunclassified

Autoimmune gastritis in children with type I diabetes mellitus

Koltuntseva

Novikova

Ревнова

et al. 2022

jour

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Diabetes mellitus continues to be the most common endocrine-metabolic pathology. In childhood, type 1 diabetes mellitus prevails - an autoimmune, genetically determined disease, as a result of which this type of diabetes is often combined with other autoimmune diseases. Autoimmune gastritis, the marker of which is antibodies to the parietal cells of the stomach, is quite rare in the children’s population, but with type 1 diabetes, its frequency increases significantly. The article presents the results of recent studies of the relationship between type 1 diabetes mellitus and autoimmune gastritis in children. The results of a study of the prevalence of antibodies to parietal cells of the stomach in type 1 diabetes mellitus in children, factors affecting this indicator are presented. The pathogenetic aspects of the relationship of these diseases are analyzed.

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Section: аутоиммунный гастрит связь с сахарным диабетом I типаunclassified

Autoimmune gastritis in children with type I diabetes mellitus

Koltuntseva

Novikova

Ревнова

et al. 2022

jour

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“…Использование Стероидная терапия позволяет достичь высокого уровня ремиссий как при типе 1 АИП (98-99%), так и при типе 2 (92%) [61]. Повторные диагностические исследования возможны после 2 нед стероидной терапии, а если не наблюдается значительного улучшения, следует предположить иную этиологию процесса [9,62].…”

Section: дифференциальнаяunclassified

“…Минимально эффективной дозой преднизолона при АИП является 30-40 мг/сут (0,6-1 мг/кг веса тела пациента) [37,62].…”

Section: дифференциальнаяunclassified

The diagnostic imaging of autoimmune pancreatitis

Luk’yanchenko¹,

Lauenstein

Романова³

2019

Vestn. rentgenol. radiol.

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Представлены основные сведения о панкреатической манифестации IgG4-ассоциированной болезни, описаны ее клинические и морфологические проявления. Подробно освещены варианты отображения данного заболевания при рентгеновской компьютерной и магнитно-резонансной томографии, в том числе при внутривенном контрастировании. Указаны отдельные причины сложностей, возникающих при дифференциальной диагностике аутоиммунного панкреатита со злокачественными опухолями поджелудочной железы. Упомянуты варианты лечения данного заболевания. Ключевые слова: аутоиммунный панкреатит; IgG4ассоциированная болезнь; компьютерная томография; магнитно-резонансная томография; обзор.

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“…There are two main types of gastrointestinal involvement, including inflammatory bowel disease (IBD) and autoimmune liver disease (ALD) ( 1 ). IBD includes ulcerative colitis (UC) and Crohn’s disease (CD), while ALD includes autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) ( 2 ). These conditions can happen both independently and together.…”

Section: Introductionmentioning

confidence: 99%

Ulcerative colitis complicated by primary sclerosing cholangitis and autoimmune hepatitis overlap syndrome: a case report and literature review

Zhang

Lin

et al. 2023

Front. Immunol.

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Primary sclerosing cholangitis (PSC), autoimmune hepatitis (AIH), and ulcerative colitis (UC) are immune diseases of the digestive system. Some patients develop overlap syndrome, the presentation of two or more of the clinical, biochemical, immunological, and histological features of these conditions simultaneously or sequentially. The incidence of UC in PSC-AIH overlap syndrome is as high as 50%. In contrast, PSC-AIH overlap syndrome is rare in UC patients. However, because it has a low prevalence and has been studied in less detail, PSC is often misdiagnosed as primary biliary cholangitis (PBC) in its early stage. Herein, we reported a case of a 38-year-old male patient who presented to a clinician in 2014 with irregular bowel habits. A colonoscopy suggested UC. In 2016, the patient was found to have abnormal liver function and was diagnosed with PBC by pathology. He was treated with ursodeoxycholic acid (UDCA) but this had no effect on his liver function. Additional liver biopsies in 2018 indicated PBC-AIH overlap syndrome. The patient refused hormone therapy for personal reasons. Following UDCA monotherapy, his liver function remained abnormal. The patient was reexamined after repeated abnormal liver function tests and bowel symptoms. Systematic laboratory testing, imaging diagnosis, colonoscopy, liver biopsy, and various pathological examinations conducted in 2021 were used to diagnose the patient with PSC-AIH-UC overlap syndrome. He was treated with various drugs, including UDCA, methylprednisolone, mycophenolate mofetil, and mesalazine. His liver function improved significantly after treatment and follow-up is ongoing. Our case report highlights the need to raise awareness about rare and difficult-to-diagnose clinical disorders.

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Autoimmune Diseases of Digestive System

Cited by 5 publications

References 0 publications

Autoimmune gastritis in children with type I diabetes mellitus

Autoimmune gastritis in children with type I diabetes mellitus

The diagnostic imaging of autoimmune pancreatitis

Ulcerative colitis complicated by primary sclerosing cholangitis and autoimmune hepatitis overlap syndrome: a case report and literature review

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