Autoimmune diseases in China

Li, Ru; Sun, Xiaohuan; Liu, Xu; Yang, Yue; Li, Zhanguo

doi:10.1016/bs.ai.2019.09.002

Cited by 14 publications

(8 citation statements)

References 199 publications

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“…On the other hand, responders were characterized by the decline of relative abundance of detrimental bacteria (including Collinsella , Escherichia-Shigella ) and other genera without an explicit role ( Fusicatenibacter , Erysipelatoclostridium and Bilophila ). For Fusicatenibacter , Erysipelatoclostridium and Bilophila , they have been described to correlate with a high fat diet, obesity, T2D, Crohn’s disease, and ulcerative colitis [ 94 , 95 , 96 , 97 ]. However, the role and relationship between the genera and AD are largely uncertain; it is anticipated that they would facilitate inflammation mediated by inducing the expression of pro-inflammatory cytokines, such as IL-17A [ 98 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of a Novel E3 Probiotics Formula on the Gut Microbiome in Atopic Dermatitis Patients: A Pilot Study

Wang

Choy²,

Lin

et al. 2022

Biomedicines

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Atopic dermatitis (AD) has been shown to be closely related to gut dysbiosis mediated through the gut–skin axis, and thus the gut microbiome has recently been explored as a potential therapeutic target for the treatment of AD. Contrasting and varying efficacy have been reported since then. In order to investigate the determining factor of probiotics responsiveness in individuals with AD, we initiated the analysis of 41 AD patients with varying disease severity in Hong Kong, whereas the severity was assessed by Eczema Area and Severity Index (EASI) by board certified dermatologist. 16S rRNA sequencing on the fecal samples from AD patients were performed to obtain the metagenomics profile at baseline and after 8 weeks of oral administration of a novel E3 probiotics formula (including prebiotics, probiotics and postbiotics). While EASI of the participants were significantly lower after the probiotics treatment (p < 0.001, paired Wilcoxon signed rank), subjects with mild AD were found to be more likely to respond to the probiotics treatment. Species richness among responders regardless of disease severity were significantly increased (p < 0.001, paired Wilcoxon signed rank). Responders exhibited (1) elevated relative abundance of Clostridium, Fecalibacterium, Lactobacillus, Romboutsia, and Streptococcus, (2) reduced relative abundance of Collinsella, Bifidobacterium, Fusicatenibacter, and Escherichia-Shigella amid orally-intake probiotics identified using the machine learning algorithm and (3) gut microbiome composition and structure resembling healthy subjects after probiotics treatment. Here, we presented the gut microbiome dynamics in AD patients after the administration of the E3 probiotics formula and delineated the unique gut microbiome signatures in individuals with AD who were responding to the probiotics. These findings could guide the future development of probiotics use for AD management.

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Section: Discussionmentioning

confidence: 99%

Effect of a Novel E3 Probiotics Formula on the Gut Microbiome in Atopic Dermatitis Patients: A Pilot Study

Wang

Choy²,

Lin

et al. 2022

Biomedicines

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“…Furthermore, the systemic comorbidity reported by the patient during medical history collection was always confirmed by reviewing medical records. Regarding the potential differences between Italy and China overall in terms of incidence of comorbidities, according to the current relevant literature there are no significant differences between the two population in terms of baseline incidence of autoimmune, inflammatory, and metabolic diseases [ 33 , 34 ]. Besides, data on comorbidities among Italians are consistent with figures reported in already published studies on endometriosis [ 5 , 35 – 38 ].…”

Section: Discussionmentioning

confidence: 99%

Comorbidities and Quality of Life in Women Undergoing First Surgery for Endometriosis: Differences Between Chinese and Italian Population

et al. 2021

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An observational cross-sectional study was conducted in a group (n = 371) of fertile age women with endometriosis, by administering a structured questionnaire, in order to evaluate the incidence of gynecological and systemic comorbidities and the impact on quality of life (QoL) in two different groups of Italian and Chinese patients affected by endometriosis. Chinese (n = 175) and Italian (n = 196) women were compared regarding systemic (inflammatory, autoimmune, and mental) and gynecological comorbidities, pain symptoms, and QoL, by using the Short Form 12 (SF-12). Italian patients resulted younger at the diagnosis and suffered more frequently from severe pain than Chinese ones. Deep infiltrating endometriosis (DIE) and mixed phenotypes were more frequent in Italian patients, whereas ovarian (OMA) and superficial endometriosis (SUP) were more common in the Chinese. The Italian group showed more systemic comorbidities, and those disorder were already present before the diagnosis of endometriosis. Furthermore, the Italian group showed lower SF-12 physical and mental scores, suggesting a worse health-related QoL in Italian endometriotic patients. A number of differences has been observed between Italian and Chinese women with endometriosis in terms of comorbidities and QoL, which may be related to the ethnicity, the different health system organization and the social and cultural background.

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“…These factors may have interfered with the assay results to some extent. Third, limited clinical information of the subjects was available such as history of autoimmune disorders or hypersensitivities that may have affected our analysis, although the prevalence of autoimmune conditions is no more than 2% in the Chinese population 39 . It would also be useful to test these biomarkers in individuals with bipolar or autism spectrum disorders, or other psychiatric diseases to determine if these abnormalities are limited to SCZ.…”

Section: Discussionmentioning

confidence: 99%

DNA hyper-methylation associated with schizophrenia may lead to breakdown of self-tolerance

Wei

Yuan

Zhu

et al. 2021

Preprint

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Environmental stressors have effects on the genomic DNA methylation patterns of B lymphocytes in schizophrenia (SCZ), which may therefore perturb the immune homeostasis and trigger autoimmune responses. This study aimed to investigate the global genomic DNA methylation differences in remitters of SCZ (RSCZ) and non-remitters of SCZ (NRSCZ), further their effects on autoimmune responses of target genes. A total of 2722 Chinese Han origin subjects were recruited, including a follow-up cohort and a cross-sectional cohort. We found a DMS of cg14341177 in SCZ which inhibit the mRNA alternative splicing of BICD2, further leading to increased plasma anti-BICD2 IgG autoantibody levels. The levels of cg14341177 methylation and anti-BICD2 IgG decreased significantly in the endpoint samples of RSCZ, but not in NRSCZ. There are strong positive correlations between cg14341177 methylation, anti-BICD2 IgG, and PANSS scores. These data suggest that cg14341177 methylation and anti-BICD2 IgG levels may potentially serve as useful biomarkers.

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Autoimmune diseases in China

Cited by 14 publications

References 199 publications

Effect of a Novel E3 Probiotics Formula on the Gut Microbiome in Atopic Dermatitis Patients: A Pilot Study

Effect of a Novel E3 Probiotics Formula on the Gut Microbiome in Atopic Dermatitis Patients: A Pilot Study

Comorbidities and Quality of Life in Women Undergoing First Surgery for Endometriosis: Differences Between Chinese and Italian Population

DNA hyper-methylation associated with schizophrenia may lead to breakdown of self-tolerance

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