Autoimmune diseases associated with non-Hodgkin lymphoma: a nationwide cohort study

Fallah, Mahdi; Liu, Xiangdong; Ji, Jianguang; Försti, Asta; Sundquist, Kristina; Hemminki, Kari

doi:10.1093/annonc/mdu365

Cited by 168 publications

(121 citation statements)

References 30 publications

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“…In previous studies reported by Hemminki et al AS patients in Sweden showed an increased risk for multiple myeloma (32), a decreased risk for digestive tract cancer (33), and no altered risk for non-Hodgkin lymphoma (34). In female cancer types of the breast, uterus, ovary and other genital organs, a low SIR in female patients with AS was noted (35).…”

Section: Female -----------------------------------------------------mentioning

confidence: 83%

Ankylosing spondylitis and the risk of cancer

Chang

Nguyễn

et al. 2017

Oncology Letters

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Abstract.Cancer is a multifactorial disease, and imbalances of the immune response and sex-associated features are considered risk factors for certain types of cancer. The present study aimed to assess whether ankylosing spondylitis (AS), an immune disorder that predominantly affects young adult men, is associated with an increased risk of cancer. Using the Taiwan National Health Insurance Research Database, a cohort of patients diagnosed with AS between 2000 and 2008 who had no history of cancer prior to enrollment was established (n=5,452). Age-and sex-matched patients without AS served as controls (n=21,808). The results revealed that the overall incidence of cancer was elevated in patients with AS [standardized incidence ratio (SIR), 1.15; 95% confidence interval (CI), 1.03-1.27]. AS carried an increased risk of hematological malignancy in both sexes, colon cancer in females and bone and prostate cancer in males. Young patients with AS (≤35 years) and patients with a Charlson comorbidity index (CCI) ≥2 experienced a higher incidence of cancer (males, SIR 1.92, and 95% CI 1.04-3.26; females, SIR 2.00 and 95% CI 1.46-5.50). The cancer risk was increased during the first 3 years following the diagnosis of AS (SIR 1.49, 95% CI 1.29-1.71), and overall cancer-free survival was significantly decreased in patients with AS patients of both sexes (P<0.0001). Therefore, AS was found to be associated with an increased risk of cancer. All AS patients must be screened for hematological malignancies, for prostate and bone cancer in males, and for colon cancer in females, particularly younger patients with a CCI ≥2.

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Section: Female -----------------------------------------------------mentioning

confidence: 83%

Ankylosing spondylitis and the risk of cancer

Chang

Nguyễn

et al. 2017

Oncology Letters

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“…Twenty-three patients were documented with NHL resulting in an SIR of 7.1 [ 3 ]. More recently, Fallah et al observed 143 NHL cases after an average 9 years of follow-up of 4,570 SS patients with an SIR of 4.9 [ 32 ]. …”

Section: The Incidence Of Non-hodgkin Lymphoma In Patients With Sjögrmentioning

confidence: 99%

“…Diffuse large B-cell lymphoma was the main histological subtype ( n = 41 cases), followed by follicular cell ( n = 28), mantle cell ( n = 4), and T-cell and small lymphocytic lymphomas (one each). In addition, this cohort included 15 other unspecifi ed NHL subtypes [ 32 ].…”

Section: Subtypes Of Sjögren Syndrome-associated Non-hodgkin Lymphomasmentioning

confidence: 99%

Lymphoproliferative Disorders Associated with Sjögren Syndrome

Tarella

Ramadan

Gueli

et al. 2016

Connective Tissue Disease

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“…In addition, the risk of hematological malignancies is also worth noting because many studies have found higher risk of hematological malignancies in patients with specifi c immunemediated diseases (8)(9)(10)(11). Th e data of population-based study of overall and site-specifi c cancer risk in patients with IBD is still scarce and all of them are carried out in Western countries (12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%