2020
DOI: 10.1016/j.beha.2019.101136
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Autoimmune disease in CMML-the chicken or the egg?

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Cited by 18 publications
(22 citation statements)
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“…Chronic inflammation thus drives clonal selection, dominance, and independence, resulting in myeloid malignancies. 21,22 Marrow failure is probably mediated by autoimmunity in some MDS subtypes, wherein immunosuppressive therapy has been successfully employed. Conversely, CMML may predispose patients to SIADS, through cytokine production by monocytes (interleukin (IL)-6, tumor necrosis factor-α, interferon regulatory factor-1) or by abnormality of immune population in MDS/CMML.…”
Section: Discussionmentioning
confidence: 99%
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“…Chronic inflammation thus drives clonal selection, dominance, and independence, resulting in myeloid malignancies. 21,22 Marrow failure is probably mediated by autoimmunity in some MDS subtypes, wherein immunosuppressive therapy has been successfully employed. Conversely, CMML may predispose patients to SIADS, through cytokine production by monocytes (interleukin (IL)-6, tumor necrosis factor-α, interferon regulatory factor-1) or by abnormality of immune population in MDS/CMML.…”
Section: Discussionmentioning
confidence: 99%
“…TET2 loss is associated with increased expression of IL-1a, IL-6, and arginase-1 by macrophages. 21,[23][24][25][26] Polyserositis is less common and thus less well studied. Polyserositis can result from malignant infiltration or alternatively from inflammation.…”
Section: Discussionmentioning
confidence: 99%
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“…With an incidence of between 10 and 20%, the immunological sequelae of CMML and MDS are now appreciated to be a significant source of morbidity in this population [4] A recent French retrospective study demonstrated significant heterogeneity in the nature of systemic inflammatory diseases associated with CMML/MDS [3]. Notably the authors identified that CMML/MDS patients with systemic inflammatory and autoimmune diseases were more likely to have adverse risk prognostic features than controls.…”
Section: Discussionmentioning
confidence: 99%
“…It is the most common subtype of the myelodysplastic (MDS) and myeloproliferative neoplasm (MPN) overlap syndromes and has markedly a heterogenous clinical phenotype [1]. There is increasing recognition of the impact that CMML has on the patient’s immune milieu [2-4].…”
Section: Introductionmentioning
confidence: 99%