Autoimmune Development in Phenotypic Type 2 Diabetes Patients

Brooks-Worrell, Barbara; Ismail, Heba M.; Wotring, Michael G.; Liemin, A.U.; Kimmie, Crystal; Felton, Jamie L.; Palmer, Jerry P.

doi:10.1016/j.clim.2007.03.367

Cited by 1 publication

(3 citation statements)

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“…The prevalence of these autoantibody negative T1D patients was estimated to comprise up to 19% of newly diagnosed T1D patients . In contrast to Wang's study, the subset of autoimmune T2D patients identified as autoimmune, with the presence of islet‐reactive T cells but negative for islet autoantibodies, comprised approximately 50% of the autoimmune T2D patients .…”

Section: Changing Ideas On T2d Pathogenesismentioning

confidence: 60%

“…It is currently not known what the prevalence of islet autoimmunity in T2D patients is. However, studies have indicated that the percentage may be as high as 50% of T2D patients . The development of islet‐reactive T cells in T2D patients may be related to the established systemic inflammation associated with obesity .…”

Section: Discussionmentioning

confidence: 99%

“…How does the presence of islet‐specific T cells correlate with β‐cell function in T2D pathophysiology? Previous studies have demonstrated that islet‐reactive T cells appeared to be associated with the progressive loss of β‐cell function in T2D patients . To investigate the interaction of islet‐specific T cells and β‐cell function, autoimmune T2D patients (positive for islet‐reactive T cells) were randomized onto a diabetes drug known to have anti‐inflammatory properties, rosiglitazone, versus a diabetes drug known to stimulate β cells but without immunoregulatory properties, glyburide in a study conducted by Brooks‐Worrell et al .…”

Section: Clinical Relevance Of Islet‐specific T‐cell Responses In T2d?mentioning

confidence: 99%

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Islet autoimmunity in phenotypic type 2 diabetes patients

Brooks-Worrell

Narla

Palmer

2013

Diabetes Obesity Metabolism

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Historically, type 2 diabetes (T2D) was considered a metabolic disease of aging. However, recent discoveries have demonstrated the role of chronic systemic inflammation in the development of insulin resistance and subsequent progression to T2D. Over the years, investigations into the pathophysiology of T2D have identified the presence of islet specific T cells and islet autoimmune disease in T2D patients. Moreover, the cell-mediated islet autoimmunity has also been correlated with the progressive loss of β-cell function associated with T2D disease pathogenesis. In this manuscript, the involvement of cell-mediated islet autoimmune disease in the progression of T2D disease and the similarities in islet specific T cell reactivity between Type 1 (T1D) and T2D are discussed.

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Section: Changing Ideas On T2d Pathogenesismentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Clinical Relevance Of Islet‐specific T‐cell Responses In T2d?mentioning

confidence: 99%

See 1 more Smart Citation