Autoimmune cytopenias in chronic lymphocytic leukemia

Haider, Muhammad S; Khan, Saleem Ahmed; Nasiruddin, .; Shahid, Samra

doi:10.12669/pjms.35.5.369

Cited by 5 publications

(9 citation statements)

References 16 publications

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“…The mean age of the patients in our study was 65.8 ± 1.5 years with the maximum number of patients falling in the group of 71-80 years. While in another local study by Ehsan AY et al, 6,7 the mean age of cohort was 62.84 years. The majority of the patients in our study were male, i.e.…”

Section: Discussionmentioning

confidence: 85%

Chronic Lymphocytic Leukemia: Autoimmune Presentations in A tertiary Care Hospital of Lahore

Rashid

Aslam³

et al. 2022

Ann Pak Inst Med Sci

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Objective: To determine the frequency of presenting features and complication in chronic lymphocytic leukaemia Methodology: This descriptive study was conducted at the Hematology department, King Edward Medical University and affiliated hospitals, from July to December 2017. For every patient, a through clinical and dermatological examination, abdominal ultrasound , bone marrow examination was done. Afresh 3 ml blood sample for CBC, immune profile, and serum testing was collected by a syringe using aseptic technique. A complete blood count was carried out using Automated Haematology Analyzer (Sysmex KX-21) and chemical examination was done on Beckman Coulter Beckman coulter. Reticulocyte count was done and direct antiglobulin test using coomb’s reagent was done. Every patient was evaluated for the creteia of SLE and was categorized accordingly. Results: Out of the 150 patients enrolled in the study, 122(81.3%) were male and 28(18.7%) patients were female. The mean age was 65.8 ± 1.33 years with the majority of patients falling in the group of 71- 80 years. Out of 150 patients, 40 (26.7%) had coombs positive. Most of the patients who had coombs positive were in stage 4. The patients who presented with complications such as paraneoplastic pemphigus were 1 out of 150 patients. Splenomegaly was found in 87.3 % of all CLL patients with 13.33% presented with massive splenomegaly .Angioedema was found in 2 out of 150 patients. No case of SLE, Sjogren s syndrome Churg strauss Syndrome, Vasculitis or Richters Trasnformation was found. Conclusion: Detection of complications in a significant number of CLL patients is related to disease progression and overall survival. The treatment modalities are different in different causes of anaemia and complications due to CLL. It will help the clinicians in modifying the treatment and decreasing the misery of patients due to co morbidities.

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Section: Discussionmentioning

confidence: 85%

Chronic Lymphocytic Leukemia: Autoimmune Presentations in A tertiary Care Hospital of Lahore

Rashid

Aslam³

et al. 2022

Ann Pak Inst Med Sci

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“…A total of 16 studies met the inclusion criteria (n = 1264 patients) [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. The summary of the included studies is provided in Table 1 and Table 2 .…”

Section: Resultsmentioning

confidence: 99%

“…The mean age across 13 of the included studies was 59 ± 6 years. Eight studies described the general hematologic and clinical profile of CLL patients who sought care at their respective institutes [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ]. The authors reported the prevalence of abnormalities noted in the patients’ complete blood profiles such as anemia, thrombocytopenia, and elevated total leukocyte count.…”

Section: Resultsmentioning

confidence: 99%

Clinical Research in Chronic Lymphocytic Leukemia in Pakistan; A Systematic Review

Ammad Ud Din,

Shahzad,

Ashraf

et al. 2023

Medicina

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Background: Significant advances have been made in the treatment of chronic lymphocytic leukemia (CLL) since the turn of the new millennium. However, most clinical trials were done in developed countries where minority ethnicities were underrepresented. Materials and Methods: To gauge the quality of research in CLL being done in Pakistan, we conducted a comprehensive literature search using PubMed, Clinicaltrials.gov, and Google Scholar on 14 January 2022 following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. Results: A total of 16 studies met the inclusion criteria. The most common study design was cross-sectional. Eight studies evaluated the clinicohematological profile of CLL patients and the effect of various cytogenic abnormalities through fluorescence in situ hybridization (FISH) technique on disease progression and prognosis. Five studies discussed the prevalence of abnormalities such as autoimmune cytopenias and other serum chemistry derangements. Only two studies evaluated treatment outcomes, among which one study reported a 2-year overall survival of 65% among patients with 17p deletion. None of the studies had patients on novel targeted agents. No pharmaceutical sponsored or funded clinical trials were found. Conclusions: Our review suggests that although small clinical studies continue to be performed across the country, multiple financial and logistical barriers need to be addressed for larger, more impactful clinical trials to be conducted that will help answer demographic-specific questions and decrease reliance on foreign studies.

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“…As a result of CLL, autoimmune hemolytic anaemia is the most prevalent cytopenia. Haemorrhagic necrosis of the blood is characterised by a high reticulocyte count and a positive direct antiglobulin test, as well as elevated serum bilirubin levels (17) . Also, there were statistical significant differences between the three stages regarding CD38, β2 microglobulin and TEMs percentage where highest levels were associated with Binet stage C group.…”

Section: Discussionmentioning

confidence: 99%

Role of Proangiogenic Tyrosine Kinase with Immunoglobulin and Endothelial Growth Factor Homology Domains 2 Expressing Monocytes in Chronic Lymphocytic Leukemia

Elsheikh¹,

Elkader²,

Soliman³

et al. 2021

The Egyptian Journal of Hospital Medicine

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Background: Globally, highest hematologic malignancy in prevalence is considered chronic lymphocytic leukemia (CLL). The expression of angiopoietin-2 (Ang2) and tyrosine kinase with immunoglobulin and endothelial growth factor homology domains (Tie1), two critical components of the Ang-Tie2 pro-angiogenic pathway, in CLL cells has been demonstrated. Objective: Clarification of Tie2-expressing monocytes' (TEMs) involvement in the pathophysiology of CLL is the goal of this study. Patients and Methods: The study was case control, which was performed on 21 CLL patients; their age ranged from 46 to 71 with a mean of 58.2 ± 6.9, in addition to 21 age and sex matched healthy control subjects. Full medical histories, clinical examinations, and laboratory tests were conducted on all individuals. The percentage of TEMs in peripheral blood was determined by flow cytometry and their phenotypic characteristics defined as CD14+/CD16+/Tie-2+ cells. Results: Compared to the control group, there was a statistically significant increase in TEMs in the cases group. Among the cases group there was a statistical significant increase in LDH, uric acid, WBCs, reticulocyte, CD 38 β2 microglobulin and TEMS and statistical significant decrease in Hb with increase Binet stage. There was a statistical significant +ve correlation between TEMs and LDH, WBCs, reticulocytes, CD38 and β2 microglobulin. Also, there was a statistical significant negative correlation between TEMs and Hb and platelets count among the cases group. TEMs percentage had sensitivity, specificity and accuracy (100%) in diagnosis of leukemia at cut off > 20.95%. Conclusion: TEMs could be a part of CLL pathogenesis which can be a predictor of disease progression alongside with other prognostic indicators.

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Autoimmune cytopenias in chronic lymphocytic leukemia

Cited by 5 publications

References 16 publications

Chronic Lymphocytic Leukemia: Autoimmune Presentations in A tertiary Care Hospital of Lahore

Chronic Lymphocytic Leukemia: Autoimmune Presentations in A tertiary Care Hospital of Lahore

Clinical Research in Chronic Lymphocytic Leukemia in Pakistan; A Systematic Review

Role of Proangiogenic Tyrosine Kinase with Immunoglobulin and Endothelial Growth Factor Homology Domains 2 Expressing Monocytes in Chronic Lymphocytic Leukemia

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