Autoimmune Antibodies in Mongol Families

Wren, Peter J J; Da, Evans; Vetters, J. M.; Chew, Andrew

doi:10.1016/s0140-6736(67)90008-6

Cited by 19 publications

(5 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, religion and paternal age, as well as maternal gravidity, parity, and number of abortions were not significantly different in the two kinds of families.g An increased frequency of thyroid antibodies in mothers of subjects with Down's syndrome has also been reported in families in north and central Italy by Burgio and coworkers 2o and Vaccaro and colleagues,21 in Canada by Dallaire and associates,22 in Czechoslovakia by Engelberth and coworkers,23 in Belgium by Vanhaelst and colleagues,24 and in Cleveland by Kaplan and Zsako; 25 one group of investigators reported negative results. 26 These data leave little doubt that there is increased prevalence of thyroid autoimmunity in the families of subjects with Down's syndrome. Three important questions remain unanswered: (1) Do mothers destined to have children with Down's syndrome have a higher frequency of thyroid autoantibodies prior to conception of the chromosomally abnormal fetuses?…”

Section: Discussionmentioning

confidence: 99%

Thyroid Autoimmunity and Down's Syndrome*

Fialkow

1970

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

Trisomy 21 is the immediate cause of Down's syndrome, but primary etiologic mechanisms have not yet been conclusively demonstrated. Among the factors mentioned as possibly predisposing to trisomy 21 are parental irradiation,1-3 maternal virus infection,-l genes enhancing the likelihood of faulty chromosomal distribution, and a factor related to parental a~t o i m m u n i t y .~ As one approach to testing the latter possibility, we have performed immunoclinical investigations on several largc groups of families in which there were subjects with Down's syndrome."-S The details of these investigations will be presented elsewhere;in this communication, the data are summarized and possible interpretations are discussed. STUDY GROUPSFour hundred and eighty-three families of subjects with Down's syndrome, ascertained in three different ways, have been investigated. These consist of 295 families who reside in Winnipeg and other areas of Manitoba (Manitoba Study); 82 families of patients living at home who were ascertained through a small private school for mentally retarded children in the Seattle area (10 families) and through the Genetics Clinics at the University of Washington Hospital and the Children's Orthopedic Hospital and Medical Center (Seattle-Home Study); and 106 families of subjects in the two state institutions for the mentally retarded in the Seattle area (Seattle-Institution Study). The parents in the Manitoba Study were matched for age and sex with Manitoba blood bank donors. Serological results in younger sibs and probands were compared with those expected for age and sex based on results obtained in 252 children without thyroid, hepatic, or chromosomal diseases who were seen at the Children's Orthopedic Hospital and Medical Center. Probands and sibs over the age of 19 years were compared with Manitoba blood bank donors. The Seattle-Clinic families were matched for maternal age with families of well babies or children with genetic diseases. Only parents were systematically studied for thyroid antibodies. The index cases in the 106 control families for the Seattle-Institution group had mental retardation not known to be associated with a chromosomal aberration. They reside in the same institutions as d o the probands with Down's syndrome, and they were matched with them for probands' age and for maternal age. Other factors, such as probands' sex, paternal age, maternal reproductive

show abstract

Section: Discussionmentioning

confidence: 99%

Thyroid Autoimmunity and Down's Syndrome*

Fialkow

1970

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

show abstract

“…High incidence of thyroid autoantibodies [1,17,55,82,96], of spontaneously occurring prccipitins of milk proteins [66], and of Australia antigen which is frequently present in patients with anicteric viral hepatitis and leukemia [3,14,90]. Pathological findings in the thymus indicat ing abnormal Hassall's corpuscles [11] which, as recently suggested, may play a role in long-term immunity [13].…”

mentioning

confidence: 99%

Impaired <i>in vitr</i><i>o</i> Response of Circulating Lymphocytes to Phytohemagglutinin in Down’s Syndrome: Dose- and Time-Response Curves and Relation to Cellular Immunity

Rigas

Elsasser

Hecht³

1970

Int Arch Allergy Immunol

View full text Add to dashboard Cite

“…Such findings are supported by publications •< -reporting on a com bination of gonadal dysgenesis and thyroid dysfunction [14,32], and by the observation th a t thyroid diseases occur more frequently in the m others of children suffering from DS [7,8]. On the other hand, Wren and his associates [35] found no cor relation between the presence of TAA and DS. A definitive conclusion in this respect is m ade difficult by the fact th a t different m ethods were em ployed for th e dem onstration of TAA, and in addition be cause observations differ as to the lim it of normal values [2,10,33].…”

Section: Resultsmentioning

confidence: 65%

“…However, other reports have been published to the contrary [13]. Certain authors found th a t th e pre sence of thyroid autoantibodies (TAA) was more frequent in children with DS and in their parents [4,10,11,15,16], a finding which the investigations of W ren and his associates [35] failed to confirm.The present study was designed to determ ine w hether (a) TAA occur more frequently in children with DS and their parents th a n in norm al individuals; (b) SA is increased in such p atie n ts; (c) the pre sence of TAA nrom oles SA. …”

mentioning

confidence: 99%

Thyroid Autoantibodies and Satellite Associations in Down’s Syndrome

Schüler

Koos²,

Siegler³

et al. 1970

Hum Hered

View full text Add to dashboard Cite

Studies of 20 children suffering from Down’s syndrome and of their parents have shown that the presence of thyroid autoantibodies was significantly more frequent in these children and in their parents than in the controls. Thyroid activity appeared to be normal in all cases of Down’s syndrome except for one child with mild hypothyroidism. Satellite association was found to be more frequent in cases of 21-trisomy (420 cells) than among controls (440 cells), but the difference was not significant. Satellite association with satellite approximation was, however, significantly more frequent in 21-trisomy. ‘G’ chromosomes were associated more frequently than ‘D’ chromosomes. The presence of thyroid autoantibodies had no effect on satellite association, either in cases of 21-trisomy or in healthy individuals.

show abstract

Autoimmune Antibodies in Mongol Families

Cited by 19 publications

References 8 publications

Thyroid Autoimmunity and Down's Syndrome*

Thyroid Autoimmunity and Down's Syndrome*

Impaired <i>in vitr</i><i>o</i> Response of Circulating Lymphocytes to Phytohemagglutinin in Down’s Syndrome: Dose- and Time-Response Curves and Relation to Cellular Immunity

Thyroid Autoantibodies and Satellite Associations in Down’s Syndrome

Contact Info

Product

Resources

About