Autoimmune and Connective Tissue Disease in Skin of Color

Singh, Babu; Walter, Scott; CallaghanIII., Daniel J.; Paek, Jennifer; Lam, Christina

doi:10.1007/978-3-319-53961-4_12

Cited by 2 publications

(3 citation statements)

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“…The clinical features in our case align with the classic presentation of morphea, demonstrating the diagnostic challenge it poses [ 9 ]. The diagnosis is mainly clinical, relying on the characteristic features of the lesions and patient history [ 10 ].…”

Section: Discussionsupporting

confidence: 69%

“…The presented case of morphea underscores the complex and multifaceted nature of this rare autoimmune skin disorder [ 9 ]. Morphea is characterized by localized areas of skin hardening and thickening, typically presenting as oval or linear-shaped lesions with variable coloration, ranging from white to reddish-brown or purple.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, genetics and biomarker research offers promise for the future [ 9 ]. Recent studies have identified genetic susceptibility factor associations with morphea and found with the HLA class II allele DRB1*04:04 and class I allele HLA-B*37 [ 2 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

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Morphea Involving the Lips and Gingiva: A Rare Case Report

Albagieh,

Alshagroud,

Aladnan

et al. 2023

Cureus

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Morphea is a subtype of scleroderma that does not involve Raynaud's phenomenon or internal organ involvement. It is a connective tissue disease that features the excessive deposition of collagen in the dermis and subcutaneous tissue, leading to a thickening of the dermis and subcutaneous tissue, eventually forming a scar-like lesion. We represent a 19-year-old male Saudi patient displaying a white patch on the marginal gingiva of tooth #21 and multiple yellowish papules on the outer surface of the lip. Both teeth #21 and #22 have experienced recession and bone loss. The patient’s clinical history and histopathology revealed characteristic features of localized scleroderma. A treatment was proposed involving immunosuppressants, methotrexate, and pimecrolimus cream along with topical corticosteroids and excimer laser therapy (308 nm). The patient followed the treatment plan for a full month and the white patch quickly improved for the patient. Afterward, the patient has been taking only methotrexate with a significant but gradual improvement. In this paper, we discuss the differential diagnosis to be considered and present an unusual occurrence of localized scleroderma in the oral cavity.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%