Autohemotherapy in Chronic Urticaria: What Could Be the Autoreactive Factors and Curative Mechanisms?

Sheikhi, Abdolkarim; Azarbeig, Mohsen; Karimi, Hamid

doi:10.5021/ad.2014.26.4.526

Cited by 10 publications

(10 citation statements)

References 8 publications

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“…Yu [18] Incomplete or internal inconsistent results in abstract; full article not available Jeon [53] No results related to research questions Sheikhi [54] Insufficient detail in letter to compute effect size or describe design; no further information available Nahm [55] Treatment consisted of autologous immunoglobulin, not whole blood or serum…”

Section: Reason For Exclusionmentioning

confidence: 99%

A Systematic Review of Autohemotherapy as a Treatment for Urticaria and Eczema

Brewer¹

2014

Cureus

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Section: Reason For Exclusionmentioning

confidence: 99%

A Systematic Review of Autohemotherapy as a Treatment for Urticaria and Eczema

Brewer¹

2014

Cureus

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“…The etiology of CU is not well understood, and the majority of cases are considered idiopathic or due to autoreactivity [4]. At this time, neither European nor US guidelines recommend extensive laboratory testing or skin biopsy [2].…”

Section: Pathogenesismentioning

confidence: 99%

Diet and Chronic Urticaria: Dietary Modification as a Treatment Strategy

Jaros

Shi

Katta

2019

Dermatol Pract Concept

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Patients with chronic urticaria (CU) often ask about dietary modification. Research has indicated that specific dietary changes may be helpful in a subset of patients. Immunological food reactions are rare, but potential triggers of CU include those seen in certain settings, as in patients with a history of tick bites, a history of raw or marinated fish ingestion, or those with celiac disease. Nonimmunological food intolerances may also contribute, although mechanism of action is not well understood. Trials of pseudoallergen-free diets and low-histamine diets have resulted in partial remission in a subset of patients, while oral provocation testing has confirmed that some patients experience worsening of symptoms after ingestion of food additives, tomatoes, herbs, seafood, alcohol, and other foods. An increased prevalence of vitamin D deficiency has also been noted in patients with CU compared with healthy controls. While oral antihistamines remain the mainstay of therapy in CU, education on potential dietary factors may be offered to a selection of the group of patients. For those at risk or reporting symptoms suggestive of celiac disease, vitamin D deficiency, delayed reactions to mammalian meat, or exposure to raw fish, further workup is recommended. While education on dietary modification may be offered to other patients, this approach may benefit only a subset, and no test is available to identify these patients. A minimum of 3 weeks may be needed to determine response, and only specific diets that have been systematically studied should be considered. Any elimination diet should be used with caution because of the potential for nutritional deficiencies.

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“…For antihistamine‐resistant patients, omalizumab, a humanized anti‐IgE antibody and, if ineffective, ciclosporin A are recommended treatment options . However, in some countries, such as China, Germany, India, Iran, South Korea, Turkey, Mexico and the United States, autohemotherapy is also commonly used to treat antihistamine‐resistant patients with CSU . As of now, the level of evidence in support of the efficacy of autohemotherapy in the treatment of patients with CSU is limited and the mechanisms of action are currently not well understood, which is why autohemotherapy as a treatment approach in CSU is controversially discussed (Appendix , Supporting Information).…”

Section: Introductionmentioning

confidence: 99%

Immunological effects and potential mechanisms of action of autologous serum therapy in chronic spontaneous urticaria

Buttgereit

Skov

et al. 2019

Acad Dermatol Venereol

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Background Autoimmune processes are considered to play a major role in the pathogenesis of chronic spontaneous urticaria (CSU). Very recently, interleukin 24 (IL‐24) has been identified as an immunoglobulin E (IgE) autoantigen in CSU. Some studies revealed that notably autologous serum skin test (ASST)‐positive CSU patients may benefit from autohemotherapy; however, the mechanisms of action remain unknown. We aimed to investigate the immunological effects of autologous serum injections in ASST‐positive CSU patients. Methods Sixty‐six ASST‐positive CSU patients were treated with weekly intramuscular autologous serum injections for 8 weeks and followed up for 12 weeks. Urticaria activity score (UAS7) and Dermatology Life Quality Index (DLQI) were assessed. The ASST was done at baseline, week 9 and week 21. Serum samples (baseline, weeks 9, 13 and/or 21) were analysed for the levels of IgE‐anti‐IL‐24 and immunoglobulin G (IgG)‐anti‐IL‐24 via ELISA and their ability to release histamine in basophils [basophil histamine release assay (BHRA)]. Results Autologous serum therapy resulted in a substantial improvement in disease activity and quality of life after 8 and 20 weeks. Twenty‐eight percent and 34% of patients turned ASST‐negative in weeks 9 and 21, respectively, but there was no link between their response to treatment and changes of ASST results. Also, no significant or relevant changes in BHRA were observed. In contrast, autologous serum therapy significantly decreased IgE‐anti‐IL‐24 serum levels, but not IgG‐anti‐IL‐24 serum levels, in responders but not in non‐responders. Conclusions Our findings suggest that the immunological effects of autologous serum therapy include a reduction in IgE‐anti‐IL24 autoantibodies, which may contribute to the pathogenesis of CSU.

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Autohemotherapy in Chronic Urticaria: What Could Be the Autoreactive Factors and Curative Mechanisms?

Cited by 10 publications

References 8 publications

A Systematic Review of Autohemotherapy as a Treatment for Urticaria and Eczema

A Systematic Review of Autohemotherapy as a Treatment for Urticaria and Eczema

Diet and Chronic Urticaria: Dietary Modification as a Treatment Strategy

Immunological effects and potential mechanisms of action of autologous serum therapy in chronic spontaneous urticaria

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