Autogenous Transplantations of Pigmented and Unpigmented Ear Skin in Guinea Pigs

Saxton, John A.; Schmeckebier, Mary M.; Kelley, Robert W.

doi:10.2307/1537372

Cited by 10 publications

(1 citation statement)

References 3 publications

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“…The results of transplantation experiments bear on some of the questions of gene action in pattern formation. In the guinea pig, skin transplants in the ear have been performed by CARNOT and DEFLANDRE (1896), LOEB (1897), and SAXTON, SCHMECKEBIER, and KELLEY (1936). These were all autoplastic except for some by the first authors.…”

Section: Transplantationmentioning

confidence: 99%

Studies on the Tricolor Pattern of the Guinea Pig. Ii. The Distribution of Black and Yellow as Affected by White Spotting and by Imperfect Dominance in the Tortoise Shell Series of Alleles

Chase

1939

Genetics

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HE tricolor pattern of the guinea pig can be analyzed into two com-T ponents: (I) the pattern of color and white and ( 2 ) the pattern of black and yellow. The former has been considered in the previous paper Pattern of black and yellowThe tortoise shell pattern consists of yellow hairs sprinkled lightly among black hairs in a few irregular, asymmetrical regions over the body. This is the typical pattern of family D, a highly inbred strain which never shows white. Occasionally a foot has a small area of segregated yellow at the tip. Large areas often appear to be solid black.The tricolor pattern of black, yellow, and white, was a feature of the earliest scientific description of the guinea pig. According to CUVIER this variety was described by ALDROVANDUS about 1550 (CASTLE 1912).Compared with the tortoise shell, the tricolor has a tendency to greater segregation of black and yellow hairs (WRIGHT 1917), giving typically i n addition to some brindling clear areas of black, yellow, and white. The individual irregularity of the black-yellow pattern is even greater than for the color-white pattern.In 1916 IBSEN proposed the symbol e p (partial extension of black) for the gene determining the tortoise shell pattern. Later (1919) he reported on the inheritance of the three alleles at this locus, E (self black) dominant over e p and e (self yellow), and e p dominant over e. The question of dominance in multiple allelic series is interesting and a quantititve study has been one of the objects in the present investigation.No statistical analysis of the array of. modifiers of this pattern has been made but the existence of such modifiers will be shown by differences in average number of yellow hairs in certain experiments.1 Submitted in partial fulhlment for the degree of Doctor of Philosophy at the University of Chicago.2 The author is grateful to PROFESSOR SEWALL WRIGHT of the University of Chicago for the suggestion of this problem, the use of pattern records, the facilities for breeding experiments, and the constant stimulating guidance throughout the work. The guinea pig colony has been maintained under a grant to the University of Chicago from the Rockefeller Foundation.

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Section: Transplantationmentioning

confidence: 99%

Studies on the Tricolor Pattern of the Guinea Pig. Ii. The Distribution of Black and Yellow as Affected by White Spotting and by Imperfect Dominance in the Tortoise Shell Series of Alleles

Chase

1939

Genetics

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Pigmentation in autoplastic and homoplastic grafts of skin from fetal and newborn hooded rats

Rawles

1955

Am. J. Anat.

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Autogenous transplantation of pigmented dorsal and ear skin to defects in white skin in various surface areas of the guinea pig

Kelley

Loeb

1939

Anat. Rec.

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ONE PLATE (ONE FIGURE)In former investigations Loeb (1897) studied the autogen017s transplantation of pigmented ear skin into defects of white skin in the ears of guinea pigs. These investigations were continued by Sale ( W ) , Seelig ( '13), and by Saxton, Schmeckebier and Kelley ('36). It was shown that the pigmented epidermis, or a t least certain of its constituents, invaded adjoining areas of the white epidermis, and it was only after a consideralde period of time that this invasion came to a conclusion.There remained tlie question as to whether the invading transplanted epithelium replaced the neigliboring host epidermis in its entirety, or whether it was merely the chromatophores of the pigiiieiited transplant which moved into the adjoining white epiderniis and supplied the latter with melanin granules. It appeared possible to answer this question experinleiitally. This possibility was based on the fact that the ear and dorsal skin of the guinea pig differ in thickness under normal conditions. By replacing the thin dorsal skin with the thicker ear skin, and vice versa, the secondarily pigmented skin in the surrounding host tissue should assume the cliaracteristic thickness of the traiisplunted skin and

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Autogenous Transplantations of Pigmented and Unpigmented Ear Skin in Guinea Pigs

Cited by 10 publications

References 3 publications

Studies on the Tricolor Pattern of the Guinea Pig. Ii. The Distribution of Black and Yellow as Affected by White Spotting and by Imperfect Dominance in the Tortoise Shell Series of Alleles

Studies on the Tricolor Pattern of the Guinea Pig. Ii. The Distribution of Black and Yellow as Affected by White Spotting and by Imperfect Dominance in the Tortoise Shell Series of Alleles

Pigmentation in autoplastic and homoplastic grafts of skin from fetal and newborn hooded rats

Autogenous transplantation of pigmented dorsal and ear skin to defects in white skin in various surface areas of the guinea pig

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