Autogenous cultured growth plate chondrocyte transplantation in the treatment of physeal injury in rabbits

Tomaszewski, Ryszard; Bohosiewicz, Janusz; Gap, Artur; Bursig, Henryk; Wysocka, Aleksandra

doi:10.1302/2046-3758.311.2000207

Cited by 15 publications

(10 citation statements)

References 23 publications

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“…The growth plate is a cartilage between the metaphyseal and epiphyseal bone at the ends of the longitudinal bones [ 20 ]. Chondrocytes in the growth plate control longitudinal growth via proliferation, hypertrophy, apoptosis, cartilage matrix synthesis, mineralization, and vascularization [ 21 ]. The growth plate can be divided into the resting, proliferative, and hypertrophic zones according to the distinctive histological chondrocyte differentiation [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Longitudinal Bone Growth Stimulating Effect of Allium macrostemon in Adolescent Female Rats

Kim

Lee

et al. 2020

Molecules

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Allium macrostemon (AM) may affect bone growth by regulating bone formation and resorption. To examine the effect of AM on bone growth, 48 rats were divided into four administration groups in which either distilled water, AM (100 and 300 mg/kg), or recombinant human growth hormone (rhGH; 20 μg/kg) was administered for 10 days. On day 9, all animals were intraperitoneally injected with tetracycline hydrochloride (20 mg/kg), and 48 h after the injection, the rats were sacrificed. Their tibial sections were photographed to measure bone growth. Antigen-specific immunohistochemistry was performed to detect insulin-like growth factor-1 (IGF-1) and bone morphogenetic protein-2 (BMP-2). The food intake of the AM 100 mg/kg group was higher; however, the food intake of the AM 300 mg/kg group was less than that of the control group. The rhGH and AM 100 mg/kg groups showed greater rates of bone growth (359.0 ± 23.7 and 373.1 ± 28.0 μm/day, respectively) compared with the control group. IGF-1 and BMP-2 in the AM and rhGH groups were highly expressed. Indigestion at higher doses of AM led to nonsignificant bone growth in spite of increased IGF-1 and BMP-2 expression. Therefore, a suitable amount of AM could increase bone growth.

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Section: Discussionmentioning

confidence: 99%

Longitudinal Bone Growth Stimulating Effect of Allium macrostemon in Adolescent Female Rats

Kim

Lee

et al. 2020

Molecules

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“…Chondrocytes can also be obtained from different compartments in autograft or allograft. In an autologous chondrocyte experiment, Tomaszewski et al (2014) resected the medial part of the proximal tibia GP in rabbits and then implanted it in the GP defects. Histological and radiological results demonstrated that implanting of autologous chondrocytes significantly prevented the bone bridge formation and growth arrest.…”

Section: Cartilage Tissue Engineering For Gp Injuriesmentioning

confidence: 99%

Enlightenment of Growth Plate Regeneration Based on Cartilage Repair Theory: A Review

Wang

et al. 2021

Front. Bioeng. Biotechnol.

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The growth plate (GP) is a cartilaginous region situated between the epiphysis and metaphysis at the end of the immature long bone, which is susceptible to mechanical damage because of its vulnerable structure. Due to the limited regeneration ability of the GP, current clinical treatment strategies (e.g., bone bridge resection and fat engraftment) always result in bone bridge formation, which will cause length discrepancy and angular deformity, thus making satisfactory outcomes difficult to achieve. The introduction of cartilage repair theory and cartilage tissue engineering technology may encourage novel therapeutic approaches for GP repair using tissue engineered GPs, including biocompatible scaffolds incorporated with appropriate seed cells and growth factors. In this review, we summarize the physiological structure of GPs, the pathological process, and repair phases of GP injuries, placing greater emphasis on advanced tissue engineering strategies for GP repair. Furthermore, we also propose that three-dimensional printing technology will play a significant role in this field in the future given its advantage of bionic replication of complex structures. We predict that tissue engineering strategies will offer a significant alternative to the management of GP injuries.

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“…77 Chondrocytes from the growth plate may be isolated, cultured and expanded in vitro and used to prevent bone bridge formation. 78,79 However, no report has used autologous chondrocytes from the growth plate for cartilage repair, primarily due to potential severe complications.…”

Section: Autologous Cartilage/costa-derived Chondrocyte Implantationmentioning

confidence: 99%

Autologous costal chondral transplantation and costa-derived chondrocyte implantation: emerging surgical techniques

Gao

et al. 2019

Therapeutic Advances in Musculoskeletal

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It is a great challenge to cure symptomatic lesions and considerable defects of hyaline cartilage due to its complex structure and poor self-repair capacity. If left untreated, unmatured degeneration will cause significant complications. Surgical intervention to repair cartilage may prevent progressive joint degeneration. A series of surgical techniques, including biological augmentation, microfracture and bone marrow stimulation, autologous chondrocyte implantation (ACI), and allogenic and autogenic chondral/osteochondral transplantation, have been used for various indications. However, the limited repairing capacity and the potential pitfalls of these techniques cannot be ignored. Increasing evidence has shown promising outcomes from ACI and cartilage transplantation. Nevertheless, the morbidity of autologous donor sites and limited resource of allogeneic bone have considerably restricted the wide application of these surgical techniques. Costal cartilage, which preserves permanent chondrocytes and the natural osteochondral junction, is an ideal candidate for the restoration of cartilage defects. Several in vitro and in vivo studies have shown good performance of costal cartilage transplantation. Although costal cartilage is a classic donor in plastic and cosmetic surgery, it is rarely used in skeletal cartilage restoration. In this review, we introduce the fundamental properties of costal cartilage and summarize costa-derived chondrocyte implantation and costal chondral/osteochondral transplantation. We will also discuss the pitfalls and pearls of costal cartilage transplantation. Costal chondral/osteochondral transplantation and costa-based chondrocytotherapy might be up-and-coming surgical techniques for recalcitrant cartilage lesions.

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Autogenous cultured growth plate chondrocyte transplantation in the treatment of physeal injury in rabbits

Cited by 15 publications

References 23 publications

Longitudinal Bone Growth Stimulating Effect of Allium macrostemon in Adolescent Female Rats

Longitudinal Bone Growth Stimulating Effect of Allium macrostemon in Adolescent Female Rats

Enlightenment of Growth Plate Regeneration Based on Cartilage Repair Theory: A Review

Autologous costal chondral transplantation and costa-derived chondrocyte implantation: emerging surgical techniques

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