Autocrine Motility Factor Receptor Expression Implies an Unfavourable Prognosis in Resected Stage I Pulmonary Adenocarcinomas

Kaynak, Kamil; Kara, Murat; B, Öz; B, Akgoz; M, Sar; A, Raz

doi:10.1080/00015458.2005.11679740

Cited by 16 publications

(10 citation statements)

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“…In a study of hepatocellular cancer cells, Wang et al reported that the patients with high expression of AMFR had higher recurrence or metastasis and shorter survival periods than those with low expression of AMFR (7). Kaynak et al also put forward that AMFR expression was a possible prognostic factor for survival and had a correlation with clinicopathological features and the 3-year survival rates of AMFR-positive and AMFR-negative patients were 47.3% and 84.6%, respectively, in stage I pulmonary adenocarcinoma (9). In this study, we examined that AMFR and its downstream target ROCK-2 were expressed in two ESCC cell lines at both mRNA and protein levels.…”

Section: Discussionmentioning

confidence: 88%

“…Aberrant expression of AMFR has been observed in many cancers and its expression level is correlated with the metastasis ability of cancer cells (7)(8)(9)(10). In a study of hepatocellular cancer cells, Wang et al reported that the patients with high expression of AMFR had higher recurrence or metastasis and shorter survival periods than those with low expression of AMFR (7).…”

Section: Discussionmentioning

confidence: 99%

“…Overexpression of AMFR has been observed in many human cancers including breast, hepatocellular, and pulmonary cancers (7)(8)(9)(10). Furthermore, aberrant activated AMFR signaling pathway also plays an important role in adjusting cell motility and invasion.…”

Section: Introductionmentioning

confidence: 99%

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Autocrine Motility Factor Receptor Signaling Pathway Promotes Cell Invasion via Activation of ROCK-2 in Esophageal Squamous Cell Cancer Cells

Wang¹,

Hou²,

Xue³

et al. 2010

Cancer Investigation

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Aberrant overexpression of autocrine motility factor and its receptor (AMFR) is observed in many cancers but not in esophageal squamous cell cancer (ESCC). In this study, upregulated rho-associated protein kinase 2, p-cofilin and intracellular adhesion molecule-1, and downregulated E-cadherin were found in ESCC cells transfected with the plasmid pcDNA 3.1-AMFR-C, while opposite results were observed in ESCC cells transfected with siRNA against AMFR. Additionally, an elevated invasion of ESCC cells by AMFR was reversed by rho-associated protein kinase 2 inhibitor Y-27632, suggesting that AMFR pathway promotes invasion of ESCC cells and may be a potential target for ESCC therapy.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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Autocrine Motility Factor Receptor Signaling Pathway Promotes Cell Invasion via Activation of ROCK-2 in Esophageal Squamous Cell Cancer Cells

Wang¹,

Hou²,

Xue³

et al. 2010

Cancer Investigation

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“…Kho et al affirmed that in human breast carcinoma the interaction of AMF with HER2 triggers HER2 phosphorylation and metalloprotease-mediated ectodomain shedding, activating PI3K and MAPK signaling and hinders trastuzumab effect (Kho et al, 2013 ). Several studies reported the overexpression of AMFR in different types of human cancer, including esophageal carcinoma, breast carcinoma, pulmonary cancer and melanoma (Tímár et al, 2002 ; Kaynak et al, 2005 ; Kojic et al, 2007 ; Wang et al, 2010a ).…”

Section: Introductionmentioning

confidence: 99%

Betulinic Acid Exerts Cytotoxic Activity Against Multidrug-Resistant Tumor Cells via Targeting Autocrine Motility Factor Receptor (AMFR)

et al. 2018

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Betulinic acid (BetA) is a naturally occurring pentacyclic triterpene isolated from the outer bark of white-barked birch trees and many other medicinal plants. Here, we studied betulinic acid's cytotoxic activity against drug-resistant tumor cell lines. P-glycoprotein (MDR1/ABCB1) and BCRP (ABCG2) are known ATP-binding cassette (ABC) drug transporters that mediating MDR. ABCB5 is a close relative to ABCB1, which also mediates MDR. Constitutive activation of the EGF receptor is tightly linked to the development of chemotherapeutic resistance. BetA inhibited P-gp, BCRP, ABCB5 and mutation activated EGFR overexpressing cells with similar efficacy as their drug-sensitive parental counterparts. Furthermore, the mRNA expressions of ABCB1, BCRP, ABCB5 and EGFR were not related to the 50% inhibition concentrations (IC50) for BetA in a panel of 60 cell lines of the National Cancer Institute (NCI), USA. In addition to well-established MDR mechanisms, we attempted to identify other molecular mechanisms that play a role in mediating BetA's cytotoxic activity. For this reason, we performed COMPARE and hierarchical cluster analyses of the transcriptome-wide microarray-based mRNA expression of the NCI cell lines panel. Various genes significantly correlating to BetA's activity were involved in different biological processes, e.g., cell cycle regulation, microtubule formation, signal transduction, transcriptional regulation, chromatin remodeling, cell adhesion, tumor suppression, ubiquitination and proteasome degradation. Immunoblotting and in silico analyses revealed that the inhibition of AMFR activity might be one of the mechanisms for BetA to overcome MDR phenotypes. In conclusion, BetA may have therapeutic potential for the treatment of refractory tumors.

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“…Similar results were seen in other studies also, where high expression of AMFR was found to be implicated in mediating invasion of lung and oral squamous cell carcinomas and promoting their metastatic capabilities (Niinaka et al, 2002 ; Takanami et al, 2002 ; Takanami and Takeuchi, 2003 ). A positive association between AMFR and metastasis was observed in melanoma cells also (Tímár et al, 2002 ); whereas, in pulmonary adenocarcinoma patients, AMFR positive subjects have shown a lower post-surgery survival rate, as compared to those having no significant AMFR expression (Kaynak et al, 2005 ).…”

Section: The Multiple Roles Of Gp78 In Cellular Proliferation: Novel mentioning

confidence: 99%

Gp78 E3 Ubiquitin Ligase: Essential Functions and Contributions in Proteostasis

Joshi

Upadhyay

Kumar

et al. 2017

Front. Cell. Neurosci.

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As per the requirement of metabolism and fitness, normal cellular functions are controlled by several proteins, and their interactive molecular and signaling events at multiple levels. Protein quality control (PQC) mechanisms ensure the correct folding and proper utilization of these proteins to avoid their misfolding and aggregation. To maintain the optimum environment of complex proteome PQC system employs various E3 ubiquitin ligases for the selective degradation of aberrant proteins. Glycoprotein 78 (Gp78) is an E3 ubiquitin ligase that prevents multifactorial deleterious accumulation of different misfolded proteins via endoplasmic reticulum-associated degradation (ERAD). However, the precise role of Gp78 under stress conditions to avoid bulk misfolded aggregation is unclear, which can act as a crucial resource to establish the dynamic nature of the proteome. Present article systematically explains the detailed molecular characterization of Gp78 and also addresses its various cellular physiological functions, which could be crucial to achieving protein homeostasis. Here, we comprehensively represent the current findings of Gp78, which shows its PQC roles in different physiological functions and diseases; and thereby propose novel opportunities to better understand the unsolved questions for therapeutic interventions linked with different protein misfolding disorders.

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Autocrine Motility Factor Receptor Expression Implies an Unfavourable Prognosis in Resected Stage I Pulmonary Adenocarcinomas

Abstract: AMFR expression predicts an unfavourable surgical outcome in patients with stage I pulmonary adenocarcinomas.

Cited by 16 publications

References 0 publications

Autocrine Motility Factor Receptor Signaling Pathway Promotes Cell Invasion via Activation of ROCK-2 in Esophageal Squamous Cell Cancer Cells

Autocrine Motility Factor Receptor Signaling Pathway Promotes Cell Invasion via Activation of ROCK-2 in Esophageal Squamous Cell Cancer Cells

Betulinic Acid Exerts Cytotoxic Activity Against Multidrug-Resistant Tumor Cells via Targeting Autocrine Motility Factor Receptor (AMFR)

Gp78 E3 Ubiquitin Ligase: Essential Functions and Contributions in Proteostasis

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