Autoclaved Autograft Bone Combined With Vascularized Bone and Bone Marrow

Taguchi, Yasushi; Pereira, Barry P.; Kour, A. K.; Pho, R. W. H.; Lee, Yoke-Sun

doi:10.1097/00003086-199511000-00035

Cited by 18 publications

(20 citation statements)

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“…Dean et al 20 found that polymethylmethacrylate discs coated with bone-marrow-impregnated poly (DL-lactic-co-glycolic acid) (PLGA) foam demonstrated increased bone formation at 3 and 6 weeks, in critical-size defects in the rabbit model, as compared with noncoated preformed polymethylmethacrylate discs. Other authors have investigated the use of bone marrow to enhance revitalization of autoclaved bone grafts 21,22 or hydroxyapatite scaffolds. 23 Based on this, the main objectives of this project were to study the osteoinductive potential of PCL scaffolds in regenerating orbital defects in pigs, and to test that the osteoinductivity could be enhanced by coating of these scaffolds with bone-marrow aspirate.…”

Section: Introductionmentioning

confidence: 99%

In vivo efficacy of bone‐marrow‐coated polycaprolactone scaffolds for the reconstruction of orbital defects in the pig

et al. 2003

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Alloplastic materials offer a number of advantages over bone autografts in the reconstruction of craniofacial defects. These include: lack of donor site morbidity, unlimited quantities of available material, and the possibility to conform exactly to the defect. An ideal bioresorbable material would degrade slowly, and have osteoconductive properties to allow replacement and remodeling by osseous tissue. This is seldom observed, the materials instead being replaced by fibrous tissue. Polycaprolactone (PCL), an FDA-approved bioresorbable polymer, has several properties that might make it suitable for reconstruction of craniofacial defects. The technique of fused deposition modeling (FDM) allows for the fabrication of highly reproducible bioresorbable 3D scaffolds. The nature of the fully interconnected pore network might enhance vascular ingrowth and osteoconductive properties. It was hypothesized that coating the scaffolds in bone marrow might enhance bone formation due to the osteoinductive nature of the bone-marrow mesenchymal cells. This study aimed to test these hypotheses in the pig model. Defects measuring 2 x 2 cm were surgically created in each orbit of eight Yorkshire pigs. The orbits were divided into three groups: Group 1 (n=4), no reconstruction (control); Group 2 (n=6), reconstruction with no coated PCL scaffolds; and Group 3 (n=6) reconstruction with bone-marrow-coated PCL scaffolds. The results were evaluated at 3 months by histological and histomorphometric analyses. The defects in Group 1 were covered with fibrous scar tissue. The shape of the reconstructed area was insufficient. The defects in Groups 2 and 3 were reconstructed correctly. In Group 2 the noncoated scaffolds showed 4.5% of new bone formation compared with 14.1% in Group 3, which is statistically significant (p<0.05). The entirely interconnected 3D polycaprolactone scaffold seems to be a promising material. It induces the bone ingrowth required for reconstructing craniofacial and orbital defects. Further long-term evaluations of these PCL scaffolds must be made in order to confirm these conclusions.

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Section: Introductionmentioning

confidence: 99%

In vivo efficacy of bone‐marrow‐coated polycaprolactone scaffolds for the reconstruction of orbital defects in the pig

et al. 2003

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“…The advantages of an autoclaved bone graft are that the graft corresponds to the size and contour of the defect, there is no rejection by the host, and it is easy to obtain as it is the subject's own tissue. The disadvantages of autoclaved bone are that it takes a long time to revascularize and incorporate into bone, and the bone itself is brittle and it becomes mechanically weaker for resorption [13]. Therefore, vascularized fibular grafts were added to the autoclaved autogeneous graft, and excellent results, both oncologically and functionally, were obtained.…”

Section: Discussionmentioning

confidence: 99%

Preservation of the knee joint in limb salvage of osteosarcoma in the proximal tibia

Amitani

Yamazaki

Sonoda

et al. 1998

International Orthopaedics

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“…The control group (n=10) and 30 rats which were ovariectomized and treated with daily heparin administration underwent a secondary surgical operation as described by Taguchi et al [18] and Uchida et al [19] Both tibiae of the rats were prepared for surgery as described above and a fracture model was created by drilling a hole in proximal tibial metaphysis.…”

Section: Second Surgical Proceduresmentioning

confidence: 99%

Histological and biomechanical effects of zoledronate on fracture healing in an osteoporotic rat tibia model

Türker

Aslan²,

Çirpar

et al. 2016

Eklem Hastalik Cerrahisi

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Autoclaved Autograft Bone Combined With Vascularized Bone and Bone Marrow

Cited by 18 publications

References 0 publications

In vivo efficacy of bone‐marrow‐coated polycaprolactone scaffolds for the reconstruction of orbital defects in the pig

In vivo efficacy of bone‐marrow‐coated polycaprolactone scaffolds for the reconstruction of orbital defects in the pig

Preservation of the knee joint in limb salvage of osteosarcoma in the proximal tibia

Histological and biomechanical effects of zoledronate on fracture healing in an osteoporotic rat tibia model

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