Autochthonous<i>Nocardia cerradoensis</i>Infection in Humans, Spain, 2011 and 2014

Ercibengoa, María; Pérez-Trallero, Emilio; Marimón, José María

doi:10.3201/eid2201.150771

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…It is a gram-positive, slightly acid-fast actinomycete originally isolated from soil. Recently, disseminated infection has been described in immunosuppressed people (Piau et al, 2015, Ercibengoa et al, 2016. It was suspected to be opportunistic in this case since the same probes previously failed to detect this organism in four otherwise healthy squirrels that had died due to trauma (personal communication, K. Stevenson).…”

Section: Discussionmentioning

confidence: 88%

Atypical Histiocytosis in Red Squirrels ( Sciurus vulgaris )

Smith

Stevenson

Del-Pozo

et al. 2017

Journal of Comparative Pathology

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Four red squirrels (Sciurus vulgaris) were subjected to necropsy examination over a 3-year period as part of a broader surveillance study. The squirrels presented with cutaneous, subcutaneous and/or internal swellings and nodules that consisted microscopically of sheets of atypical round cells and multinucleated giant cells. There was moderate anisokaryosis with rare mitoses. Nuclei ranged from oval to indented or C-shaped and some were bizarre, twisted or multilobulated. Many giant cells also had a bizarre morphology, with anisokaryosis within individual cells. Giant cell nuclei were often multilobulated, ring-shaped or segmented. Affected internal organs varied depending on the squirrel, but included lymph node, kidney, intestinal tract and lungs. Representative lesions from each of the four squirrels were negative for acid-fast organisms. Formalin-fixed tissues from all four squirrels and ethanol-fixed tissue from one animal were negative for Mycobacterium by polymerase chain reaction. Immunohistochemically, the majority of mononuclear and multinucleated giant cells in all four squirrels strongly expressed vimentin and class II molecules of the major histocompatibility complex. Otherwise, the atypical mononuclear and multinucleated cells were negative for CD3, Pax-5, Mac387, CD18 and E-cadherin. Based on the combination of cellular morphology, arrangement and immunophenotype, a novel form of atypical histiocytosis is considered most likely in these squirrels, although the exact origin and triggering factors remain uncertain.

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Section: Discussionmentioning

confidence: 88%

Atypical Histiocytosis in Red Squirrels ( Sciurus vulgaris )

Smith

Stevenson

Del-Pozo

et al. 2017

Journal of Comparative Pathology

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“…Nocardia cerradoensis was initially described in Brazilian soil ( 1 ); as a pathogen it was first noticed causing disseminated infection in a patient who had received a kidney graft ( 2 ). Although N. cerradoensis has been proposed as an emerging global pathogen ( 3 ), no genome of an N. cerradoensis clinical strain has previously been sequenced. Here, we describe the draft genome sequence of N. cerradoensis CNM20130759, isolated from a postinfiltration cutaneous infection on the knee of a 52-year-old immunocompetent woman ( 4 ).…”

Section: Genome Announcementmentioning

confidence: 99%

First Draft Genome Sequence of a Clinical Strain of Nocardia cerradoensis

et al. 2017

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“…Nocardia cerradoensis is a newly and rare species identified after 2000, with a clinical preference for skin and soft tissues 14 . Although pulmonary nocardiosis is the most common presentation, CNS can be involved in 44% of cases; being isolated in only 9% of cases 15,16 . In CNS nocardiosis, the disease may be clinically silent, and if symptoms thought to be due to mass lesions rather than infection may be misdiagnosed as a neoplasm initially, especially given the rarity of nocardiosis 1,17 .…”

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confidence: 99%

“…14 Although pulmonary nocardiosis is the most common presentation, CNS can be involved in 44% of cases; being isolated in only 9% of cases. 15,16 In CNS nocardiosis, the disease may be clinically silent, and if symptoms thought to be due to mass lesions rather than infection may be misdiagnosed as a neoplasm initially, especially given the rarity of nocardiosis. 1,17 Moreover, Nocardia infection on FDG PET/CT can mimic metastases in other locations, as adrenal gland.…”

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confidence: 99%

Brain Nocardiosis Defined by 18F-Fluorocholine PET/CT

et al. 2023

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Nocardia infection (nocardiosis) is usually acquired by inhalation; so pulmonary nocardiosis is the most common clinical presentation. Extrapulmonary localization occurs through hematogenous dissemination or contiguous spread. Nocardia can involve the central nervous system in a very reduced number of patients, mainly in immunocompromised. We present a case of a 56-year-old woman with a history of aggressive systemic mastocytosis, treated with chemotherapy 1 year ago. Patient reported intense headache, disorientation, and blurry vision without other symptoms being diagnosed with a rare brain nocardiosis by Nocardia cerradoensis. Neither bacteremia nor pulmonary involvement was detected. Brain PET/CT illustrated 18F-fluorocholine avidity on brain abscesses.

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AutochthonousNocardia cerradoensisInfection in Humans, Spain, 2011 and 2014

Cited by 4 publications

References 9 publications

Atypical Histiocytosis in Red Squirrels ( Sciurus vulgaris )

Atypical Histiocytosis in Red Squirrels ( Sciurus vulgaris )

First Draft Genome Sequence of a Clinical Strain of Nocardia cerradoensis

Brain Nocardiosis Defined by 18F-Fluorocholine PET/CT

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