Autochthonous human alveolar echinococcosis in a Hungarian patient

Dezsényi, Balázs; Strausz, Tamás; Makrai, Z.; Csomor, Judit; Danka, József; Kern, Peter; Rezza, Giovanni; Barth, Thomas F.E.; Casulli, Adriano

doi:10.1007/s15010-016-0918-7

Cited by 9 publications

(6 citation statements)

References 8 publications

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“…The first reported cases from neighbouring Belgium appeared nearly exclusively in Wallonia [ 55 , 56 ]. Also for the first time in Hungary, a case of AE was thought to be autochthonous in the south-west of the country [ 57 ]. Evidence of the disease was found for the first time in Poland and in five patients in north-eastern Romania by molecular genetic testing [ 58 , 59 ].…”

Section: Resultsmentioning

confidence: 99%

“…No Czech cases were registered between 1998 and 2006, however 20 cases in the period of 2007–2014 [ 62 ]. We can assume the further spread of the disease from the first molecular genetic evidence for the existence of human AE in Romania, as well as the first autochthonous case from south-western Hungary [ 57 , 59 ]. Despite some high estimated figures of more than 1000 new cases annually [ 5 ], there is a distinct lack of data from Russia.…”

Section: Discussionmentioning

confidence: 99%

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Worldwide literature on epidemiology of human alveolar echinococcosis: a systematic review of research published in the twenty-first century

et al. 2019

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Purpose Human alveolar echinococcosis (AE) is a potentially lethal zoonosis caused by the cestode Echinococcus multilocularis. The aim of this systematic review is to establish a comprehensive global AE literature overview taking into account the epidemiologically relevant AE research of the twenty-first century. Methods We systematically searched the global literature published from 2001 through 2018 via MEDLINE, EMBASE, the Russian databases eLIBRARY.RU, CyberLeninka, the Chinese databases CNKI, VIP, Journals.research.ac.ir (Farsi language-based), Jordan E-Library (Arab language-based) and supplementary Google Scholar, in accordance with the PRISMA guidelines. QGIS software was used for the mapping of the affected countries. Results We have listed 154 relevant publications in the final literature synopsis in consideration of our quality assessment. Including non-autochthonous cases, human AE was reported in 36 countries within the northern hemisphere from 2001 to 2018. The first publication of AE in Tajikistan,

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Worldwide literature on epidemiology of human alveolar echinococcosis: a systematic review of research published in the twenty-first century

et al. 2019

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“…6,7,41,42 In Europe, cases in the hitherto endemic area of Central Europe (France, Switzerland, Germany and Austria) are increasing in number. Moreover, the geographical distribution is expanding to countries previously considered AE-free like Poland, Slovakia, Hungary and the Baltic region, [43][44][45][46][47][48] challenging respective health care systems. 21 Key risk factors for acquiring AE in Europe are being a farmer, owning a dog or cat or having a kitchen garden.…”

Section: Key Pointmentioning

confidence: 99%

Parasites of the liver – epidemiology, diagnosis and clinical management in the European context

Peters¹,

Burkert²,

Grüner

2021

Journal of Hepatology

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Parasites in the liver cause significant global morbidity and mortality, as they can lead to recurrent cholangitis, cirrhosis, liver failure and cancer. Due to climate change and globalisation, their incidence is increasing, especially in Europe. The correct diagnosis of a hepatic parasite is often delayed because clinicians are unfamiliar with respective entities. Therefore, in this review, we aim to provide clinicians with a comprehensive clinical picture of hepatic parasites and to bring these neglected parasitic liver diseases to the wider attention of hepatology stakeholders in Europe and around the world.

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“…It is suggested that, due to this antigen, the metacestode of AE escapes the host immune response as shown in animal models [13][14][15] by modulating the T-cell response and activating a T-cell-independent B-cell reaction, which lacks antibody maturation. With conventional immunohistochemical staining of paraffin sections of archived paraffin material, staining with the antibody is highly sensitive and specific for AE [16]. Furthermore, this technique revealed an unknown feature of human AE that we called "small particles of E. multilocularis", i.e., spems [5,17,18].…”

Section: Immunohistological Findingsmentioning

confidence: 99%

Morphological Characteristics of Alveolar and Cystic Echinococcosis Lesions in Human Liver and Bone

Barth

Casulli

2021

Pathogens

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Among echinococcoses diseases of human interest, two have a global public health impact: cystic and alveolar echinococcosis caused by Echinococcus granulosus sensu lato and Echinococcus multilocularis, respectively. Cystic and alveolar echinococcosis are neglected infectious diseases epidemiologically and are clinically vastly different with distinct microscopic features. Because of the rareness of these zoonotic diseases, pathologists have limited diagnostic experience in the analysis of the lesions caused by Echinococcus tapeworms. Here, we describe the main microscopic features to be considered to characterize these lesions: laminated layer, central necrosis, growth pattern, and delineation from adjacent tissue. Moreover, immunohistology using monoclonal antibodies is of great diagnostic help in reaching a definitive diagnosis by identifying the laminated body and small particles of E. multilocularis (spems) and small particles of E. granulosus (spegs).

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Autochthonous human alveolar echinococcosis in a Hungarian patient

Cited by 9 publications

References 8 publications

Worldwide literature on epidemiology of human alveolar echinococcosis: a systematic review of research published in the twenty-first century

Worldwide literature on epidemiology of human alveolar echinococcosis: a systematic review of research published in the twenty-first century

Parasites of the liver – epidemiology, diagnosis and clinical management in the European context

Morphological Characteristics of Alveolar and Cystic Echinococcosis Lesions in Human Liver and Bone

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