Autochthonous Case of Eosinophilic Meningitis Caused by <i>Angiostrongylus cantonensis</i>, France, 2016

Nguyen, Yann; Rossi, Benjamín; Argy, Nicolas; Baker, Catherine; Nickel, Beatrice; Marti, H R; Zarrouk, Virginie; Houzé, Sandrine; Fantin, Bruno; Lefort, A.

doi:10.3201/eid2306.161999

Cited by 30 publications

(26 citation statements)

References 9 publications

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“…However, to date, only a single autochthonous human case of angiostrongyliasis has been reported from France in 2016. Imported food could not be ruled out as a possible source of contamination, local active transmission could not be confirmed [12].…”

Section: Discussionmentioning

confidence: 99%

Angiostrongylus cantonensis in North African hedgehogs as vertebrate hosts, Mallorca, Spain, October 2018

et al. 2019

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In October 2018, two Atelerix algirus hedgehogs were admitted to the Wildlife Rehabilitation Hospital in Mallorca (Balearic Islands, Spain) with signs of acute neurological disease. Necropsy detected immature, fully developed nematodes in the subarachnoid space of both hedgehogs, including a gravid female worm. DNA-based molecular tools confirmed the nematode as Angiostrongylus cantonensis , an important aetiological agent of eosinophilic meningitis in humans. So far this zoonotic parasite in has not been reported in western European wildlife.

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Section: Discussionmentioning

confidence: 99%

Angiostrongylus cantonensis in North African hedgehogs as vertebrate hosts, Mallorca, Spain, October 2018

et al. 2019

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“…In order to enable complete comparison with the FAO/WHO ranking results, parasites not expected to be found in Europe, except as imported cases, such as Paragonimus spp., Heterophyidae and Spirometra spp., were included in the prioritisation. Workshop participants supplemented the list of parasites to be prioritised with Angiostrongylus cantonensis because of its potential future emergence in Europe given its presence on the Canary Islands [ 13 ] and since then the first autochthonous case was reported in France [ 14 ]. In addition, for the purpose of the European list, T. gondii was divided into its main clinical entities, congenital and acquired toxoplasmosis, according to transmission route to both allow for distinction based on the difference in transmission routes and comparisons with the global burden of food-borne disease study’s ranking based on DALY [ 5 ].…”

Section: Methodsmentioning

confidence: 99%

Prioritisation of food-borne parasites in Europe, 2016

et al. 2018

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Background and aimsPriority setting is a challenging task for public health professionals. To support health professionals with this and in following a recommendation from the Food and Agriculture Organization of the United Nations (FAO) and World Health Organization (WHO), 35 European parasitologists attended a workshop from 8–12 February 2016 to rank food-borne parasites (FBP) in terms of their importance for Europe and regions within Europe. Methods: Countries were divided into European regions according to those used by the European Society of Clinical Microbiology and Infectious Diseases. We used the same multicriteria decision analysis approach as the FAO/WHO, for comparison of results, and a modified version, for better regional representation. Twenty-five FBP were scored in subgroups, using predefined decision rules. Results: At the European level, Echinococcus multilocularis ranked first, followed by Toxoplasma gondii and Trichinella spiralis. At the regional level, E. multilocularis ranked highest in Northern and Eastern Europe, E. granulosus in South-Western and South-Eastern Europe, and T. gondii in Western Europe. Anisakidae, ranking 17th globally, appeared in each European region’s top 10. In contrast, Taenia solium, ranked highest globally but 10th for Europe. Conclusions: FBP of importance in Europe differ from those of importance globally, requiring targeted surveillance systems, intervention measures, and preparedness planning that differ across the world and across Europe.

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“…Humans and mice, non-permissive hosts, become infected by eating raw intermediate hosts, including Pomacea canaliculate and Ampullaria crossean [ 2 ]. In recent years, due to the wide spread of snails and slugs, the disease is no longer restricted to certain areas [ 3 , 4 ]. AC has become a major threat to both human beings and wildlife species globally.…”

Section: Introductionmentioning

confidence: 99%

Chi3l3: a potential key orchestrator of eosinophil recruitment in meningitis induced by Angiostrongylus cantonensis

Wan

Sun

et al. 2018

J Neuroinflammation

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BackgroundAngiostrongylus cantonensis, an important foodborne parasite, can induce serious eosinophilic meningitis in non-permissive hosts, such as mouse and human. However, the characteristics and mechanisms of the infection are still poorly understood. This study sought to determine the key molecules and its underlying mechanism in inducing brain eosinophilic infiltration caused by Angiostrongylus cantonensis.MethodsMathematical models were established for prediction of significantly changing genes and the functional associated protein with RNA-seq data in Angiostrongylus cantonensis infection. The expression level of Chi3l3, the predicted key molecule, was verified using Western blotting and real-time quantitative PCR. Critical cell source of Chi3l3 and its relationship with eosinophils were identified with flow cytometry, immunohistochemistry, and further verified by macrophage depletion using liposomal clodronate. The role of soluble antigens of Angiostrongylus cantonensis in eosinophilic response was identified with mice airway allergy model by intranasal administration of Alternaria alternate. The relationship between Chi3l3 and IL-13 was identified with flow cytometry, Western blotting, and Seahorse Bioscience extracellular flux analyzer.ResultsWe analyzed the skewed cytokine pattern in brains of Angiostrongylus cantonensis-infected mice and found Chi3l3 to be an important molecule, which increased sharply during the infection. The percentage of inflammatory macrophages, the main source of Chi3l3, also increased, in line with eosinophils percentage in the brain. Network analysis and mathematical modeling predirect a functional association between Chi3l3 and IL-13. Further experiments verified that the soluble antigen of Angiostrongylus cantonensis induce brain eosinophilic meningitis via aggravating a positive feedback loop between IL-13 and Chi3l3.ConclusionsWe present evidences in favor of a key role for macrophave-derived Chi3l3 molecule in the infection of Angiostrongylus cantonensis, which aggravates eosinophilic meningitis induced by Angiostrongylus cantonensis via a IL-13-mediated positive feedback loop. These reported results constitute a starting point for future research of angiostrongyliasis pathogenesis and imply that targeting chitinases and chitinase-like-proteins may be clinically beneficial in Angiostrongylus cantonensis-induced eosinophilic meningitis.Electronic supplementary materialThe online version of this article (10.1186/s12974-018-1071-2) contains supplementary material, which is available to authorized users.

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Autochthonous Case of Eosinophilic Meningitis Caused by Angiostrongylus cantonensis, France, 2016

Cited by 30 publications

References 9 publications

Angiostrongylus cantonensis in North African hedgehogs as vertebrate hosts, Mallorca, Spain, October 2018

Angiostrongylus cantonensis in North African hedgehogs as vertebrate hosts, Mallorca, Spain, October 2018

Prioritisation of food-borne parasites in Europe, 2016

Chi3l3: a potential key orchestrator of eosinophil recruitment in meningitis induced by Angiostrongylus cantonensis

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