Autocatalytic deposition of nickel

Dennis, J.K.; Such, T.E.

doi:10.1016/b978-0-408-01124-2.50015-2

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…[ 268 ] The cytosolic phospholipase A2 α (cPLA2 α ), a Ca 2+ ‐dependent cytosolic enzyme, controls AA release from PUFAs. [ 269,270 ] Cerebral ischemia‐induced influx of Ca 2+ activates cPLA2 α to enhance LPO. cPLA2 α is increased after cerebral ischemia, and its knockdown can significantly decrease LPO and brain injury.…”

Section: Ferroptosis In Neurological Diseasesmentioning

confidence: 99%

Pharmacological Inhibition of Ferroptosis as a Therapeutic Target for Neurodegenerative Diseases and Strokes

Wang

et al. 2023

Advanced Science

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Emerging evidence suggests that ferroptosis, a unique regulated cell death modality that is morphologically and mechanistically different from other forms of cell death, plays a vital role in the pathophysiological process of neurodegenerative diseases, and strokes. Accumulating evidence supports ferroptosis as a critical factor of neurodegenerative diseases and strokes, and pharmacological inhibition of ferroptosis as a therapeutic target for these diseases. In this review article, the core mechanisms of ferroptosis are overviewed and the roles of ferroptosis in neurodegenerative diseases and strokes are described. Finally, the emerging findings in treating neurodegenerative diseases and strokes through pharmacological inhibition of ferroptosis are described. This review demonstrates that pharmacological inhibition of ferroptosis by bioactive small‐molecule compounds (ferroptosis inhibitors) could be effective for treatments of these diseases, and highlights a potential promising therapeutic avenue that could be used to prevent neurodegenerative diseases and strokes. This review article will shed light on developing novel therapeutic regimens by pharmacological inhibition of ferroptosis to slow down the progression of these diseases in the future.

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Section: Ferroptosis In Neurological Diseasesmentioning

confidence: 99%