Autobiographical Memory in Healthy Aging: a Decade-long Longitudinal Study

Frankenberg, C.; Knebel, Maren; Degen, Christina; Siebert, Jelena; Wahl, Hans‐Werner; Schröder, Johannes

doi:10.1080/13825585.2020.1859082

Cited by 13 publications

(10 citation statements)

References 48 publications

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“…As all forms of knowledge (e.g., semantic, episodic, autobiographical) emerges from simulation, a consequence of this hypothesis is that memory deficits in older people should not be limited to newly learned knowledge. Coherently, older adults also recall less specific perceptual or spatiotemporal details in autobiographical memory tasks (very long-term memory see, Frankenberg et al, 2021 ). A better understanding of the changes requires to study the neurophysiological mechanisms underlying memory in the MTL (the hippocampus and surrounding cortex) and the effect of age on them.…”

Section: Sensory-perceptual Decline and Low-resolution Representation In Agingmentioning

confidence: 99%

“…Their memory difficulties are then not limited to a given memory system, but rather occur due to the alteration of mechanisms involved in the emergence of specific knowledge. Thus, not only do older adults have less detailed specific knowledge in episodic tasks (specific knowledge, Greene and Naveh-Benjamin, 2020 ; Frankenberg et al, 2021 ), but they also less benefit from distinctiveness (see Smith, 2006 ) due to a more generic (categorial) and less distinct processing ( Koutstaal and Schacter, 1997 ; Smith, 2006 ).…”

Section: Distinctiveness Of Memory Traces On Other Cognitive Domainsmentioning

confidence: 99%

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Low-Resolution Neurocognitive Aging and Cognition: An Embodied Perspective

Mille

Brambati

Izaute

et al. 2021

Front. Syst. Neurosci.

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Consistent with embodied cognition, a growing evidence in young adults show that sensorimotor processing is at the core of cognition. Considering that this approach predicts direct interaction between sensorimotor processing and cognition, embodied cognition may thus be particularly relevant to study aging, since this population is characterized by concomitant changes in sensorimotor and cognitive processing. The present perspective aims at showing the value and interest to explore normal aging throughout embodiment by focusing on the neurophysiological and cognitive changes occurring in aging. To this end, we report some of the neurophysiological substrates underpinning the perceptual and memory interactions in older adults, from the low and high perceptual processing to the conjunction in the medial temporal lobe. We then explore how these changes could explain more broadly the cognitive changes associated with aging in terms of losses and gains.

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Section: Sensory-perceptual Decline and Low-resolution Representation In Agingmentioning

confidence: 99%

Section: Distinctiveness Of Memory Traces On Other Cognitive Domainsmentioning

confidence: 99%

Low-Resolution Neurocognitive Aging and Cognition: An Embodied Perspective

Mille

Brambati

Izaute

et al. 2021

Front. Syst. Neurosci.

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“…The control for delusional memories was guaranteed via consultation of staff members and review of patients' case notes and psychiatric reports. Psychometric properties of the semi-structured autobiographical interview (Cronbach's α = .572-.863; interrater reliability: .954-.979) were established in previous studies of our group (Ahlsdorf, 2009;Frankenberg et al, 2021).…”

Section: Assessment Of Autobiographical Memory and Additional Neurops...mentioning

confidence: 72%

Autobiographical memory impairment in chronic schizophrenia: Significance and clinical correlates

Herold

Lässer

Schröder

2022

Journal of Neuropsychology

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Previous studies of autobiographical memory (AM) in schizophrenia yielded a reduction of specificity, richness of details and conscious recollection, which indicate both, quantitative and qualitative AM changes. However, their associations with psychopathological symptoms and neuropsychological deficits were not resolved. Therefore, we sought to investigate AM with respect to psychopathology and neuropsychology in patients with chronic schizophrenia to rule out the influence of different courses of the disease. AM of four lifetime periods was examined in 75 patients and 50 healthy controls by using a semi-structured interview.

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“…To integrate the E-AGI into the routine diagnostic testing, the interview was abbreviated to three of the original five different lifetime periods: primary school, early adulthood, and recent 5 years. Further methodological details, including the psychometric properties of the E-AGI, have been described in previous studies ( 1 , 4 ).…”

Section: Methodsmentioning

confidence: 99%

“…Autobiographical memory (AM) refers to a form of declarative, long-term memory comprising knowledge of a person's own past. Changes in AM are typically observed in healthy aging, e.g., by a reduction of specificity and temporo-spatial or perceptual details ( 1 ). However, pronounced losses of AM, including important events of one's own past, form one of the clinical hallmarks of Alzheimer's disease (AD) ( 2 ) and may affect central components of the subjective sense of identity ( 3 ), which illustrates the particular importance of AM.…”

Section: Introductionmentioning

confidence: 99%

Neural Correlates of Autobiographical Memory: Evidence From a Positron Emission Tomography Study in Patients With Mild Cognitive Impairment and Alzheimer's Disease

et al. 2021

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Background: Autobiographical memory (AM) changes are the hallmark of Alzheimer's disease (AD) and mild cognitive impairment (MCI). In recent neuroimaging studies, AM changes have been associated with numerous cerebral sites, such as the frontal cortices, the mesial temporal lobe, or the posterior cingulum. Regional glucose uptake in these sites was investigated for underlying subdimensions using factor analysis. Subsequently, the factors were examined with respect to AM performance in a subgroup of patients.Methods: Data from 109 memory clinic referrals, who presented with MCI (n = 60), mild AD (n = 49), or were cognitively intact, were analyzed. The glucose metabolic rates determined by positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) in 34 cerebral sites important for AM were investigated for underlying subdimensions by calculating factor analysis with varimax rotation. Subsequently, the respective factor scores were correlated with the episodic and semantic AM performance of 22 patients, which was measured with a semi-structured interview assessing episodic memories (characterized by event-related emotional, sensory, contextual, and spatial–temporal details) and personal semantic knowledge from three periods of life (primary school, early adulthood, and recent years).Results: Factor analysis identified seven factors explaining 69% of the variance. While patients with MCI and AD showed lower values than controls on the factors frontal cortex, mesial temporal substructures, and occipital cortex, patients with MCI presented with increased values on the factors posterior cingulum and left temporo-prefrontal areas. The factors anterior cingulum and right temporal cortex showed only minor, non-significant group differences. Solely, the factor mesial temporal substructures was significantly correlated with both episodic memories (r = 0.424, p < 0.05) and personal semantic knowledge (r = 0.547, p < 0.01) in patients with MCI/AD.Conclusions: The factor structure identified corresponds by large to the morphological and functional interrelations of the respective sites. While reduced glucose uptake on the factors frontal cortex, mesial temporal substructures, and occipital cortex in the patient group may correspond to neurodegenerative changes, increased values on the factors posterior cingulum and left temporo-prefrontal areas in MCI may result from compensatory efforts. Interestingly, changes of the mesial temporal substructures were correlated with both semantic and episodic AM. Our findings suggest that AM deficits do not only reflect neurodegenerative changes but also refer to compensatory mechanisms as they involve both quantitative losses of specific memories and qualitative changes with a semantization of memories.

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Autobiographical Memory in Healthy Aging: a Decade-long Longitudinal Study

Cited by 13 publications

References 48 publications

Low-Resolution Neurocognitive Aging and Cognition: An Embodied Perspective

Low-Resolution Neurocognitive Aging and Cognition: An Embodied Perspective

Autobiographical memory impairment in chronic schizophrenia: Significance and clinical correlates

Neural Correlates of Autobiographical Memory: Evidence From a Positron Emission Tomography Study in Patients With Mild Cognitive Impairment and Alzheimer's Disease

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