Autoantigenic properties of the aminoacyl tRNA synthetase family in idiopathic inflammatory myopathies

Preger, Charlotta; Notarnicola, A.; Hellström, Cecilia; Wigren, Edvard; Fernandes‐Cerqueira, Cátia; Kvarnström, Marika; Wahren‐Herlenius, Marie; Idborg, Helena; Lundberg, Ingrid E.; Persson, Helena; Gräslund, S.; Jakobsson, Per‐Johan

doi:10.1016/j.jaut.2022.102951

Cited by 8 publications

(7 citation statements)

References 63 publications

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“…Recently, a summary of studies analyzing the performance of LIA for the detection of anti-OJ antibodies concluded poor performance of LIA for the detection of anti-OJ [25]. Poor performance was also observed in a recent study by Preger et al [55 ▪▪ ] as well as by Vulsteke et al [24] who detected anti-OJ antibodies via IP-MS in a serum that was negative by LIA.…”

Section: Anti-oj Elucidatedmentioning

confidence: 88%

Update on autoantibodies and related biomarkers in autoimmune inflammatory myopathies

Choi,

Satoh,

Fritzler

2023

Current Opinion in Rheumatology

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Purpose of review This manuscript reviews recently published advances in the identification of autoimmune inflammatory myopathies (AIM)-specific and AIM-related autoantibodies considered of value in the workup of patients suspected of having AIM. Newer autoantibodies, developments, and advances in the methodology of testing, the gaps and pitfalls in using these assays as diagnostic biomarkers, and the importance of considering overlap diseases and unique clinical AIM phenotypes are discussed. Recent findings Summary The spectrum of autoantibodies and related biomarkers in AIM continues to expand. Many of these have clear clinical implications in regard to subsets and overlap conditions of AIM, associated malignancy and pathological findings.

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Section: Anti-oj Elucidatedmentioning

confidence: 88%

Update on autoantibodies and related biomarkers in autoimmune inflammatory myopathies

Choi,

Satoh,

Fritzler

2023

Current Opinion in Rheumatology

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“…Along the same line, the group of Karolinska has uncovered the presence of serum immune-reactivity toward practically all aminoacyl tRNA synthetases in patients with IM. Although the relevance of these findings is yet to be clarified, it appears that closing the serological gap of the ARS syndrome could increase sensitivity for IPAF diagnosis ( 31 ).…”

Section: Discussionmentioning

confidence: 99%

Fine-tuning characterization of patients with interstitial pneumonia and an underlying autoimmune disease in real-world practice: We get closer with Nailfold videocapillaroscopy

Romero-Bueno

Rodríguez-Nieto²,

Miras³

et al. 2023

Front. Med.

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ObjectivesTo assess performance of interstitial pneumonia (IP) with autoimmune features (IPAF) criteria in clinical practice and describe the utility of additional workup in identifying patients with underlying connective tissue diseases (CTD).MethodsWe set a retrospective study of our patients with autoimmune IP, who were allocated to CTD-IP, IPAF or undifferentiated autoimmune IP (uAIP) subgroups according to the updated classification criteria. Presence of the process-related variables comprising IPAF defining domains was scrutinized in all patients, and, when available, the results of nailfold videocapillaroscopy (NVC) were recorded.ResultsThirty nine out of 118 patients, accounting for 71% of former undifferentiated cases, fulfilled IPAF criteria. Arthritis and Raynaud’s phenomenon were prevalent in this subgroup. While systemic sclerosis-specific autoantibodies were restricted to CTD-IP patients, anti-tRNA synthetase antibodies were also present in IPAF. In contrast, rheumatoid factor, anti-Ro antibodies and ANA nucleolar patterns could be found in all subgroups. Usual interstitial pneumonia (UIP) / possible UIP were the most frequently observed radiographic patterns Therefore, the presence of thoracic multicompartimental findings as also performance of open lung biopsies were useful in characterizing as IPAF those UIP cases lacking a clinical domain. Interestingly, we could observe NVC abnormalities in 54% of IPAF and 36% of uAIP tested patients, even though many of them did not report Raynaud’s phenomenon.ConclusionBesides application of IPAF criteria, distribution of IPAF defining variables along with NVC exams help identify more homogeneous phenotypic subgroups of autoimmune IP of potential relevance beyond clinical diagnosis.

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“…Besides, a recent Swedish study showed that almost all cytoplasmic aminoacyl tRNA synthetases (ARS) can act as autoantigens, leading to the discovery of autoantibodies against nine novel ARS (82). Notably, autoantibodies targeting new ARS were found in some previously seronegative IIM patients, with crucial diagnostic and prognostic implications (82). Although their true clinical value has yet to be defined, as they are common to other autoimmune disorders, antibodies to valosin-containing protein (anti-VCP) were detected in 26.0% of patients with sporadic IBM with a significant specificity (87.2%) but low sensitivity (26.0%) (83).…”

Section: Autoantibodiesmentioning

confidence: 99%

Idiopathic inflammatory myopathies: one year in review 2023

Conticini,

Dourado,

Bottazzi

et al. 2024

Clinical and Experimental Rheumatology

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Idiopathic inflammatory myopathies are a group of rare, autoimmune, diseases typically involving striate muscle and also variously affecting several other systems or organs, such as joints, skin, lungs, heart and gastrointestinal tract. IIM are mainly characterised by subacute onset and chronic course and are burdened by significant morbidity and mortality. Despite the rarity of these conditions, several efforts have been undertaken in the last years to better understand their pathogenesis, as well as to achieve a more precise classification and to define the optimal therapeutic approach. The aim of this review is to provide an up-to-date digest of the most relevant studies published on this topic over the last year.

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Autoantigenic properties of the aminoacyl tRNA synthetase family in idiopathic inflammatory myopathies

Cited by 8 publications

References 63 publications

Update on autoantibodies and related biomarkers in autoimmune inflammatory myopathies

Update on autoantibodies and related biomarkers in autoimmune inflammatory myopathies

Fine-tuning characterization of patients with interstitial pneumonia and an underlying autoimmune disease in real-world practice: We get closer with Nailfold videocapillaroscopy

Idiopathic inflammatory myopathies: one year in review 2023

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