Abstract:Objectives. Studies have demonstrated that B cells play important roles in systemic sclerosis (SSc), especially through the gCD19/CD22 autoimmune loop h. In this study, we examined the presence and functional property of circulating autoantibodies reacting with CD22.
Methods. Serum samples from 10 tight skin (TSK/+) mice and 50 SSc patients were assessed for anti-CD22 autoantibodies by enzyme-linked immunosorbent assays using recombinant mouse or human CD22. The association between anti-CD22 ant… Show more
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