Autoantibodies to the high-affinity IgE receptor in children with chronic urticaria

Toit, George Du; Prescott, Ruth; Lawrence, Patricia; Johar, Asmah; Brown, Geraldine; Weinberg, Eugene; Motala, C.; Potter, Paul

doi:10.1016/s1081-1206(10)61245-8

Cited by 83 publications

(79 citation statements)

References 19 publications

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“…Our results were found compatible with the frequencies of CAU reported in the literature (40% and 47%) (23,24).…”

Section: Discussionsupporting

confidence: 93%

High-dose anti-histamine use and risk factors in children with urticaria

Uysal¹,

Avcıl²,

Erge³

2016

Turk Pediatri Ars

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Aim: The drugs of choice in the treatment of urticaria in children are H1-antihistamines. The aim of the study was to evaluate children with urticaria and define risk factors for requirement of high-dose H1-antihistamines in children with urticaria. Material and Methods:The medical data of children who were diagnosed as having urticaria admitted to our outpatient clinic between January 2014 and January 2016 were searched. The medical histories, concomitant atopic diseases, parental atopy histories, medications, treatment responses, blood eosinophil and basophil counts, and serum total IgE levels were recorded. In addition, the urticaria activity score for seven days, autoimmune antibody tests, and skin prick test results were evaluated in children with chronic urticaria. Results:The numbers of the children with acute and chronic urticaria were 138 and 92, respectively. The age of the children with chronic urticaria was higher than that of those with acute urticaria (p<0.0001). There was no difference between the two groups in terms of blood eosinophil and basophil counts, and serum total IgE levels (p>0.05). There was a negative correlation between blood eosinophil count and the UAS7 score in children with chronic urticaria (r=-0.276, p=0.011). Chronic urticaria and requirement of high dose H1-antihistamines were significant in children aged ≥10 years (p<0.001, p=0.015). High UAS7 score (OR: 1.09; CI 95%: [1.03-1.15]) and basopenia (OR: 6.77; CI 95%: [2.01-22.75]) were associated with the requirement of high-dose H1-AH in children with chronic urticaria. Conclusion:The requirement of high-dose H1-antihistamines was higher with children's increasing age. Disease severity and basopenia were risk factors for the requirement of high-dose H1-antihistamines. (Turk Pediatri Ars 2016; 51: 198-203)

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“…Our results were found compatible with the frequencies of CAU reported in the literature (40% and 47%) (23,24).…”

Section: Discussionsupporting

confidence: 93%

High-dose anti-histamine use and risk factors in children with urticaria

Uysal¹,

Avcıl²,

Erge³

2016

Turk Pediatri Ars

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“…A positive weal and flare reaction is considered indicative of circulating autoantibodies to the high-affinity IgE receptor on the mast cell in CU patients [67]. The ASST is poorly tolerated by younger children due to the discomfort associated with intradermal injections performed in the absence of topical anaesthetic creams [18]. The role of the basophil histamine release assay (BRA) in the clinical management of CU remains unclear.…”

Section: Investigationsmentioning

confidence: 99%

“…Most are spontaneous with physical factors such as pressure or cold exposure being the most commonly diagnosed precipitating factors. 31-47% of children with CU have an autoimmune aetiology with a positive ASST [18,19]. About 4% of children with CU have positive antithyroid antibodies, the majority of these are euthyroid [101] (Table 2).…”

Section: Aetiology and Mechanismsmentioning

confidence: 99%

BSACI guideline for the management of chronic urticaria and angioedema

Powell

Leech

Till

et al. 2015

Clin Experimental Allergy

248

221

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SummaryThis guidance for the management of patients with chronic urticaria and angioedema has been prepared by the Standards of Care Committee of the British Society for Allergy and Clinical Immunology (BSACI). The guideline is based on evidence as well as on expert opinion and is aimed at both adult physicians and paediatricians practising in allergy. The recommendations are evidence graded. During the development of these guidelines, all BSACI members were included in the consultation process using a Web-based system. Their comments and suggestions were carefully considered by the Standards of Care Committee. Where evidence was lacking, a consensus was reached by the experts on the committee. Included in this management guideline are clinical classification, aetiology, diagnosis, investigations, treatment guidance with special sections on children with urticaria and the use of antihistamines in women who are pregnant or breastfeeding. Finally, we have made recommendations for potential areas of future research.

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“…IgE has been frequently associated with CU (25). IL-4 causes a switch to IgE production through B-cell differentiation; however, IFN-γ inhibits that switch, preventing the production of specific IgE (26).…”

Section: Discussionmentioning

confidence: 99%

Effects of the polysaccharide nucleic acid fraction of bacillus Calmette-Guérin on the production of interleukin-2 and interleukin-10 in the peripheral blood lymphocytes of patients with chronic idiopathic urticaria

Autoantibodies to the high-affinity IgE receptor in children with chronic urticaria

Cited by 83 publications

References 19 publications

High-dose anti-histamine use and risk factors in children with urticaria

High-dose anti-histamine use and risk factors in children with urticaria

BSACI guideline for the management of chronic urticaria and angioedema

Effects of the polysaccharide nucleic acid fraction of bacillus Calmette-Guérin on the production of interleukin-2 and interleukin-10 in the peripheral blood lymphocytes of patients with chronic idiopathic urticaria

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