Autoantibodies to SS-A/Ro in infants with congenital heart block

Reed, Barbara R.; Lee, Lela A.; Harmon, Catherine; Wolfe, R. W.; Wiggins, James W.; Peebles, Carol; Weston, William L.

doi:10.1016/s0022-3476(83)80707-0

Cited by 118 publications

(34 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…AntiRo antibodies are present in 30-50% of lupus patients, and, when present in pregnant women (in association with anti-La responses), are associated with congenital heart block in offspring. 30 In many instances, somatic mutation may play an important role in the development of pathogenic, highaffinity autoantibody responses 3,31 and some mutated, high-affinity anti-self antibodies demonstrate lower affinity for antigen when 'revertant' mutations are introduced. The inhibitory influence of RN86 upon phagocytic uptake of apoptotic cells is particularly relevant, given the fact that the antibody does not appear to carry significantly mutated V regions, although the junctional changes that the antibody exhibits would no doubt influence antigenic recognition.…”

Section: Reactivity Of the Immunizing Antibody (Rn86) Is Shown For Rementioning

confidence: 99%

Anti-idiotype-mediated epitope spreading and diminished phagocytosis by a human monoclonal antibody recognizing late-stage apoptotic cells

et al. 2006

View full text Add to dashboard Cite

Apoptotic cells are considered an important auto-antigenic source in diseases such as systemic lupus erythematosus (SLE). A human monoclonal antibody demonstrating exquisite specificity towards late-stage apoptotic cells was generated from an SLE patient. Polyreactive recognition of ribonucleoproteins Ro52 and Ro60 was observed. The antibody significantly diminished the phagocytosis of apoptotic cells and a concomitant decrease in transforming growth factor-b (TGF-b) secretion was observed. Light and heavy chain sequencing revealed the antibody to be in essentially germline configuration. Elicited anti-idiotypic antibodies bound distinct self-antigens and showed augmented reactivity towards apoptotic cells as well. Thus, near-germline encoded antibodies recognizing antigens externalized during the process of apoptosis can mediate a variety of potentially pathogenic effects; decreases in the phagocytic uptake of dying cells would constitute a disease-perpetuating event and stimulation of the idiotypic network could lead to intermolecular epitope spreading, increasing the range of molecular targets.

show abstract

Section: Reactivity Of the Immunizing Antibody (Rn86) Is Shown For Rementioning

confidence: 99%

Anti-idiotype-mediated epitope spreading and diminished phagocytosis by a human monoclonal antibody recognizing late-stage apoptotic cells

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Finally, the typical association of maternal antibodies to Ro(SS-A) has been described for CHB in 1983 [4,5], whereas another syndrome, cutaneous NLE, has been described in 1981 [6,7] (table 1). Discoid LE in a newborn infant with subsequent development of SLE in the mother 3 1981 Association of NLE with antibodies to Ro/SS-A 6, 7 1983 Association of CHB with anti-Ro/SS-A antibodies 4, 5 …”

Section: Introductionmentioning

confidence: 99%

Significance of Autoantibodies in Neonatal Lupus Erythematosus

Dörner

Feist²,

Chaoui³

et al. 2000

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Autoantibodies produced by the mother and transported into the fetal circulation are of significant importance in the diagnosis of neonatal lupus syndromes. These humoral autoimmune findings provide an unique opportunity to assess the pathogenic role of autoantibodies against the Ro(SS-A)/La(SS-B) complex, most notably for congenital heart block. Current knowledge about the involved autoantibody-autoantigen systems, including recent therapeutic concepts of these autoimmune syndromes, is summarized.

show abstract

“…Congenital heart block is well known to frequently occur in infants born to mothers with anti-Ro antibody [14]. In adult SLE patients, myocarditis and conduction defects are reportedly more frequently in anti-Ro antibodypositive individuals than in anti-Ro antibody-negative patients [15].…”

Section: Discussionmentioning

confidence: 99%

Development of various arrhythmias and conduction disturbances following corticosteroid therapy for systemic lupus erythematosus with antiphospholipid syndrome

et al. 2010

View full text Add to dashboard Cite

A 45-year-old Chinese woman with active systemic lupus erythematosus, lupus anticoagulant positive, was admitted to our hospital. Electrocardiography on admission was normal. Though anti-Sjögren's syndrome A (anti SS-A/Ro) antibodies were negative and ultrasound cardiographic findings were normal, she developed various arrhythmias/conduction disturbances shortly after starting corticosteroid. Nearly all were resolved with continuous corticosteroid and aspirin therapy before discharge. Vasculitis, the presence of antiphospholipid antibodies, and platelet aggregation due to corticosteroid were possible mechanisms underlying the arrhythmias/conduction disturbances.

show abstract

Autoantibodies to SS-A/Ro in infants with congenital heart block

Cited by 118 publications

References 17 publications

Anti-idiotype-mediated epitope spreading and diminished phagocytosis by a human monoclonal antibody recognizing late-stage apoptotic cells

Anti-idiotype-mediated epitope spreading and diminished phagocytosis by a human monoclonal antibody recognizing late-stage apoptotic cells

Significance of Autoantibodies in Neonatal Lupus Erythematosus

Development of various arrhythmias and conduction disturbances following corticosteroid therapy for systemic lupus erythematosus with antiphospholipid syndrome

Contact Info

Product

Resources

About