Autoantibodies to Reticulin in Patients With Idiopathic Steatorrhœa, Cœliac Disease, and Crohn's Disease, and Their Relation to Immunoglobulins and Dietary Antibodies

Alp, Mete; Wright, Ralph

doi:10.1016/s0140-6736(71)92249-5

Cited by 86 publications

(49 citation statements)

References 13 publications

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“…The IF staining pattern observed closely resembled the staining pattern given by silver impregnation of reticular fibres [Gormori, 1937] in the same tissues, and this type of ARA was subsequently designated the R1 type by Rizzetto and Doniach [1973]. The association between circulating Rl-ARA and untreated gluten sensitive enteropathy is well es tablished [Seah et al, 1971[Seah et al, , 1973Alp and Wright, 1971;Brown et al, 1973;Lancaster-Smith et al, 1975], and the fact that the R 1 -ARA disappears from the cir culation within weeks of starting a strict gluten-free diet (GFD) [Alp and Wright, 1971;Seah et al, 1973;Unsworth et al, 1981a] and reappears soon after glu ten challenge [Alp and Wright, 1971;Unsworth et al, 1981a], suggests that gluten ingestion by predisposed individuals provokes Rl-ARA production. The fact that children with non-gluten sensitive enteropathies do not have circulating Rl-ARA [Unsworth et al, 1983] suggests that small intestinal villous atrophy alone does not cause reticulin autosensitisation.…”

Section: Introductionsupporting

confidence: 57%

“…In support of the first suggestion, Seah et al [1973] claimed that Frazer's fraction III (Fill) derived from BDH gluten, absorbed R1 ARA reactivity from the majority of the sera tested. However, this is disput ed by others [Alp and Wright, 1971;Brown et al, 1973;Magalhaes et al, 1974] who failed to show any ab sorption of R1 ARA activity with F ill or with a range of other wheat protein preparations. It should be not ed, however, that none of these investigators tried to absorb anti-gliadin antibody (AGA) with reticulin, mainly because purified reticulin is not available.…”

Section: Introductionmentioning

confidence: 88%

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Studies on the Significance of the R1 Anti-Reticulin Antibody Associated with Gluten Sensitivity

Unsworth

Walker-Smith²,

McCarthy

et al. 1985

Int Arch Allergy Immunol

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The R1 type anti-reticulin antibody (ARA) is closely associated with gluten-sensitive enteropathy. It disappears from the circulation within a few weeks of starting on a gluten-free diet and often reappears following gluten challenge. It is not clear how gluten ingestion leads to the production of the ARA. We have investigated four possibilities. (1) The ARA is simply a food antibody generated against meats in the diet. (2) The ARA is an anti-gluten antibody which cross-reacts with reticulin. (3) Gluten binds to gut reticulin in vivo rendering reticulin autoimmunogenic. (4) Immune complexes of gluten and anti-gluten antibody bind to reticulin (by virtue of the affinity that gluten has for reticulin) to give the appearance of an ARA in immunofluorescence tests. Our results do not support any of these possible explanations, and the significance of the ARA remains obscure.

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Section: Introductionsupporting

confidence: 57%

Section: Introductionmentioning

confidence: 88%

Studies on the Significance of the R1 Anti-Reticulin Antibody Associated with Gluten Sensitivity

Unsworth

Walker-Smith²,

McCarthy

et al. 1985

Int Arch Allergy Immunol

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“…Alp and Wright (1971) found this antibody in 3700 of adult coeliacs and demonstrated an association with dietary gluten which we were able to confirm by this present study. The significance of antibodies against reticulin is obscure.…”

Section: Discussionsupporting

confidence: 87%

Coeliac disease and autoimmunity

Lancaster-Smith

Swarbrick

Perrin

et al. 1974

Postgraduate Medical Journal

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Summary Among fifty-seven patients with proven coeliac disease three also had thyrotoxicosis, two insulin dependant diabetes, three fibrosing alveolitis and one each had vitiligo, rheumatoid arthritis and cryptogenic cirrhosis. Autoantibodies were demonstrated in twelve of thirty-one patients tested, seven of these twelve had one of the above associated conditions. Antireticulin antibodies were found in seven of twenty-three patients tested, and there was a significant association with dietary gluten. These findings appear to support that coeliac disease is associated with disturbed immunity and that a predisposition to autoimmunity may exist.

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“…Stromal reticulin in the connective tissue was investigated also by IF, using sera obtained from patients with the malabsorption syndrome (Alp and Wright, 1971), containing antibodies to reticulin (courtesy of Dr. A. Fagraens). All sera were kept frozen (-70 ~ C) until the cervical tissues were examined.…”

Section: Lmmunofluorescence (If)mentioning

confidence: 99%

The basement membrane in experimentally induced atypias and carcinoma of the uterine cervix in mice

Rubio

Biberfeld

1979

Virchows Arch. A Path. Anat. and Histol.

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Basement membrane-specific antigens of the squamous epithelium of the uterine cervix were investigated in 19 normal mice, in 7 mice with cervical atypia and in 3 mice with invasive carcinoma. Cervical atypia and carcinoma were induced by local application of benzo(a)pyrene. Basement membrane-specific antigens were demonstrated by immunofluorescence with sera from patients with bullous pemphigoid. Both normal squamous cervical epithelium and atypical cervical epithelium showed the presence of a continuous, clearly delineated basement membrane. Clusters of invasive squamous carcinoma were also surrounded by a fluorescent basement membrane which, however, appear fragmented or discontinuous. The results suggest that the ability of cervical squamous cells to secrete basement membrane antigens is not completely lost during carcinogenesis, thus substantiating our previous observations in the cervix of human subjects.

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Autoantibodies to Reticulin in Patients With Idiopathic Steatorrhœa, Cœliac Disease, and Crohn's Disease, and Their Relation to Immunoglobulins and Dietary Antibodies

Cited by 86 publications

References 13 publications

Studies on the Significance of the R1 Anti-Reticulin Antibody Associated with Gluten Sensitivity

Studies on the Significance of the R1 Anti-Reticulin Antibody Associated with Gluten Sensitivity

Coeliac disease and autoimmunity

The basement membrane in experimentally induced atypias and carcinoma of the uterine cervix in mice

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