Autoantibodies to Prolactin-Secreting Cells of Human Pituitary

Bottazzo, G. F.; Florin-Christensen, A; Pouplard, A; Doniach, Deborah

doi:10.1016/s0140-6736(75)90004-5

Cited by 179 publications

(76 citation statements)

References 10 publications

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“…The endocrinological features seen at the end of this study were compatible with LAH, decreased response of TSH, GH and FSH and increased response of prolactin to the respective stimulating hypothalamic hormones. Several reports have suggested that LAH might have caused acquired isolated deficiency of pituitary hormones [1,[18][19][20][21][22]. Actually, several types of isolated pituitary hormone deficiency associated with LAH have been reported [13,[22][23][24][25][26].…”

Section: Discussionmentioning

confidence: 99%

Longitudinal Study of Patients with Idiopathic Isolated TSH Deficiency: Possible Progression of Pituitary Dysfunction in Lymphocytic Adenohypophysitis

et al. 2006

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Abstract. The relationship between isolated TSH deficiency and hypophysitis was studied. Six patients (five women and one man) with idiopathic isolated TSH deficiency were longitudinally investigated with an interval of 31 to 60 months. Clinical symptoms, laboratory results and endocrine function were investigated as well as pituitary magnetic resonance imaging (MRI) at the start and the end of the study. Clinically, initial symptoms due to hypothyroidism were ameliorated by the thyroid hormone replacement in all patients. Oligomenorrhea newly appeared during the study in three patients, although no other symptoms appeared. Serum fT3 and fT4 levels were within the reference ranges, and serum TSH level and its response to TRH stimulation remained low in all patients. Peak plasma GH level during GRH stimulation was significantly (p<0.03) decreased, at the end of the study as compared with the start. Peak plasma FSH level to LHRH stimulation was significantly (p<0.03) decreased as well as basal FSH level. In contrast, peak of prolactin during TRH stimulation was significantly (p<0.03) increased at the end of the study as compared with the start as well as basal prolactin level. Endocrine features at the end of the study were compatible with those of lymphocytic adenohypophysitis (LAH). MRI of the pituitary gland showed empty sella in one patient and slight swelling in two patients. These findings remained unchanged during the study period. One patient underwent pituitary biopsy, with histological examination showing atypical form of LAH. LAH can cause idiopathic isolated TSH deficiency and can functionally progress to combine dysfunction of the pituitary gland.

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Section: Discussionmentioning

confidence: 99%

Longitudinal Study of Patients with Idiopathic Isolated TSH Deficiency: Possible Progression of Pituitary Dysfunction in Lymphocytic Adenohypophysitis

et al. 2006

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“…Si l'apparition chez les bovins d'une destruction autoimmune de l'hypophyse n'a jamais, à notre connaissance, été décrite, une telle hypothèse peut néanmoins être étayée par d'autres exemples, en pathologie humaine et animale ; -une « hypophysite » a déjà été décrite chez l'homme [1,8]. Sa coexistence possible avec la présence d'auto-anticorps dirigés contre des types cellulaires précis de l'ante-hypophyse .permet d'envi sager la réalité d'une telle atteinte autoimmune au moins dans trois circonstances : 0 au cours de .certaines polyendocrinopathies [2] ; 0 au cours de certains déficits ante-hypophysaires surtout dis sociés [7] et du post-partum [10] ; 0 dans le diabète insulino-dépendant de type 1 [3,9] ; -on peut en rapprocher, dans le domaine de la pathologie animale, les hy.pophysites expérimentales obtenues par injection …”

Section: Discussionunclassified

Maladie de la hyène chez les bovins : une hypophysite d’origine autoimmune ? Résultats préliminaires d’une étude histologique et immunocytochimique

Pouplard¹,

Constantin²,

Espinasse³

et al. 1982

bavf

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Histological examinations on the hypophysis of animals suffering from Hyena's disease revealed the existence of a lymphocytic hypophysitis. This fact, together with the presence of antibodies directed against the cells of the anterior hypophysis in the serum of the same animals, indicates that the disease may be of auto-immune origin. However, the necessity remains to perform additional epidemiological endocrinological, immunological and immunogenetic studies in order to reveal the cause of Hyena's disease.

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“…have reported the prevalence of circulating antipituitary antibodies (APA) using different techniques in various autoimmune diseases [1][2][3][4][5][6][7][8]. As early as 1975, Bottazzo et al [1] showed the existence of APA to prolactin secretor cells of human pituitary in insulin-dependent diabetes mellitus, using an indirect fluorescent antibody technique [2].…”

Section: Several Investigatorsmentioning

confidence: 99%

“…As early as 1975, Bottazzo et al [1] showed the existence of APA to prolactin secretor cells of human pituitary in insulin-dependent diabetes mellitus, using an indirect fluorescent antibody technique [2]. In 1986, Sugiura et al [3] developed a sensitive assay for APA, based on avidin-biotin detection technique and rat pituitary antigens.…”

Section: Several Investigatorsmentioning

confidence: 99%

Detection of Antipituitary Antibodies in Patients with Autoimmune Thyroid Disease.

et al. 2001

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Abstract.The aim of the present study was to investigate the prevalence of antipituitary antibodies (APA) in patients with autoimmune thyroid disease as determined by Western blot analysis and enzyme-linked immunosorbent assay (ELISA).Results by Western blot analysis showed positivity for APA in serum of 22.4% of patients with Graves' disease (n= 143, p<0.05) and 18.5% of patients with Hashimoto's thyroiditis (n=54, p<0.05), which were significantly higher than 6.2% in healthy controls (n=97).Similar results were obtained with ELISA.

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Autoantibodies to Prolactin-Secreting Cells of Human Pituitary

Cited by 179 publications

References 10 publications

Longitudinal Study of Patients with Idiopathic Isolated TSH Deficiency: Possible Progression of Pituitary Dysfunction in Lymphocytic Adenohypophysitis

Longitudinal Study of Patients with Idiopathic Isolated TSH Deficiency: Possible Progression of Pituitary Dysfunction in Lymphocytic Adenohypophysitis

Maladie de la hyène chez les bovins : une hypophysite d’origine autoimmune ? Résultats préliminaires d’une étude histologique et immunocytochimique

Detection of Antipituitary Antibodies in Patients with Autoimmune Thyroid Disease.

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