Autoantibodies to parietal cells as predictors of atrophic body gastritis: A five-year prospective study in patients with autoimmune thyroid diseases

Clustering of additional autoimmunity behaves differently in Hashimoto's patients compared with Graves' patients

“…In our study, 20% of both Hashimoto's and Graves' disease patients showed gastric autoimmunity, comparable to previous reports in adults (24), while in children, even higher percentages have been found (25). Moreover, we found a prevalence of vitamin B12 deficiency of 9.7 and 8.3% in Hashimoto's and Graves' disease respectively.…”

Hashimoto's Thyroiditis and Entero-Chromaffin-like Cell Hyperplasia: Early Detection and Somatostatin Analogue Treatment

“…This apparent discrepancy might be attributed to variable accuracy of diagnostic methods. In some studies, diagnosis of AIG was based only on the positivity of PCA (1,8). We performed EGOS only on selected HT patients with hypergastrinemia, increased CgA serum levels, and PCA positivity.…”

“…The association of AIG with autoimmune thyroid diseases (AlTO) is well known, but its prevalence varies widely in literature reports, depending on the type of patient studied, the diagnostic accuracy and the immunological methods used for the detection of AIG-associated autoantibodies (5)(6)(7). The prevalence of serum PCA in AlTO was estimated to vary between 24 and 29%, being slightly higher in Graves' disease patients than in HT patients (1,8). Gastric endocrine cancers (EC) are considered rare, underdiagnosed tumors, that account for approximately for 0.1-0.6 % of all carcinomas of the stomach, and frequently metastasize to lymph nodes and the liver even in the early stages of the disease, therefore early detection and therapeutic effort are essential for improving the prognosis (9,10).…”

“…The autoimmune attack to the parietal cells results in decreased acid secretion and hypergastrinemia (1). Hypergastrinemia promotes the growth of the ECL cells of the oxyntic mucosa so that diffusion to micronodular ECL cell hyperplasia develops and, after a latent period of many years, carcinoid and multiple ECL tumors in 10% of the cases (2,3).…”

“…(PCA) directed against the proton pump (H+/ K+ ATPase) (1). The autoimmune attack to the parietal cells results in decreased acid secretion and hypergastrinemia (1).…”