Autoantibodies to Nonhistone Nuclear Antigens

Sharp, Gordon C.; Alspaugh, Margaret A.

doi:10.1007/978-1-4613-2493-5_7

Cited by 13 publications

(5 citation statements)

References 86 publications

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“…[1][2][3] They reported that almost all of these patients have arthralgia, and 60%-70% have arthritis that is nonerosive and nondeforming. 1 However, subsequent studies on the clinical and radiographic manifestations of MCTD have shown that more than 30% of patients have developed erosive arthritis and joints like those seen in patients with rheumatoid arthritis (RA).…”

Section: Introductionmentioning

confidence: 99%

Anticyclic citrullinated peptide antibodies in patients with mixed connective tissue disease

et al. 2004

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The clinical significance of anticyclic citrullinated peptide (CCP) antibodies in patients with mixed connective tissue disease (MCTD) was assessed. Altogether, 86 sera from MCTD patients, 96 from rheumatoid arthritis (RA) patients, 42 from systemic lupus erythematosus (SLE) patients, 23 from systemic sclerosis (SSc) patients, 21 from polymyositis/dermatomyositis (PM/DM) patients, and 17 from those with Sjögren's syndrome (SjS) were tested for anti-CCP antibodies using an enzyme-lined immunosorbent assay. Among the 96 RA patients, anti-CCP antibodies were detected in 85%, with the frequency being significantly higher than in MCTD, SLE, SSc, PM/DM, and SjS patients (9%, 14%, 13%, 14%, and 18%, respectively; P < 0.001). Among eight MCTD patients who fulfilled the diagnostic criteria for RA, only 50% had anti-CCP antibodies, and the prevalence was significantly lower than for all RA patients (p < 0.01). All eight patients who fulfilled the criteria for RA had overlap of SLE and SSc, except one patient, whereas the four anti-CCP-positive patients who did not fulfill the criteria for RA had SjS without overlapping features of SLE and SSc; moreover, most of their antibody titers were low. These results suggested that anti-CCP antibodies are associated with RA in MCTD patients, but careful diagnosis of RA is required if patients with low titers of anti-CCP antibodies lack overlapping SLE and SSc.

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Section: Introductionmentioning

confidence: 99%

Anticyclic citrullinated peptide antibodies in patients with mixed connective tissue disease

et al. 2004

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“…MCTD is characterized by overlapping of the symptoms of SLE, systemic sclerosis (SSc), and polymyositis (PM), as well as by the presence of anti-RNP antibodies (9). Such patients rarely develop antibodies t o dsDNA, and another disease marker would therefore be very helpful.…”

mentioning

confidence: 99%

Changes in anti–U1 RNA antibody levels correlate with disease activity in patients with systemic lupus erythematosus overlap syndrome

Hoet

Koornneef

Rooij

et al. 1992

Arthritis & Rheumatism

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Objective. To evaluate correlations between changes in a n t i 4 1 RNA antibody levels and disease activity in 9 patients with systemic lupus erythematosus (SLE) overlap syndrome who were prospectively followed up for at least 3 years.Methods. Anti-U1 RNA antibody levels were measured quantitatively, using a nitrocellulose filter binding assay. Disease activity was measured with a validated SLE activity index.Results. All 9 major disease exacerbations were associated with peaks in a n t i 4 1 RNA antibody level.Conclusion. These results seem to indicate that measuring a n t i 4 1 RNA antibody levels can be useful for monitoring disease activity.Sera from patients with connective tissue diseases often contain antibodies against proteins present in small nuclear ribonucleoprotein (snRNP) particles (1). These snRNPs contain a uridine-rich RNA and

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“…3A and 3B, lanes I) [6,8]. On immunoblots, the UI-70K protein is often seen as a triplet [28], whereas the VI-C band may have a very broad appearance, sometimes separating into at least two bands.…”

Section: Nuclear Antigensmentioning

confidence: 98%

“…Some other autoantibodies are found in more than one syndrome, e.g. anti-Ul RNP in mixed connective tissue disease (MCTD) [1,6] and SLE [7,8], anti-R060/SS-A and anti-La/SS-B in Sjogren's syndrome and SLE [9,10], and anti-histone in both SLE and drug-induced SLE [2]. Therefore, the determination of serological autoantibodies reactive with cellular antigens located in the nucleus or the cytoplasm can be helpful in the classification of patients with rheumatic diseases [11].…”

Section: Introductionmentioning

confidence: 99%