2017
DOI: 10.1111/ijd.13827
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Autoantibodies to full body vascular cell junctions colocalize with MYZAP, ARVCF, desmoplakins I and II and p0071 in endemic pemphigus in Colombia, South America

Abstract: Immune response to these vascular antigens is likely altering endothelial cells and vessel shapes, thus disturbing hemodynamic flow. The flow alterations likely lead to inflammation and may play a role in the atherogenesis often seen in these patients.

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Cited by 3 publications
(2 citation statements)
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References 37 publications
(125 reference statements)
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“…We observed an autoimmune response to neural receptors in El Bagre-EPF patients’ oral mucosa and salivary glands; indeed, we have described autoreactivity to skin neurovascular structures and neural receptors in previous studies [ 27 , 28 ]. The neuronal/transmitter control of salivary glands is performed by both dopaminergic and serotonergic neurons and receptors [ 29 ].…”
Section: Discussionsupporting
confidence: 73%
“…We observed an autoimmune response to neural receptors in El Bagre-EPF patients’ oral mucosa and salivary glands; indeed, we have described autoreactivity to skin neurovascular structures and neural receptors in previous studies [ 27 , 28 ]. The neuronal/transmitter control of salivary glands is performed by both dopaminergic and serotonergic neurons and receptors [ 29 ].…”
Section: Discussionsupporting
confidence: 73%
“…We performed immunostaining of skin samples with anti-MYZAP antibodies in the family to evaluate if there was protein expression as it had been described in pemphigus patients. 2 A similar distribution of the MYZAP staining pattern was observed in all individuals, which was preferentially located in perivascular areas, but with a weaker expression in samples from carriers of biallelic variants (Figure B).…”
supporting
confidence: 66%