Autoantibodies Present in Hidradenitis Suppurativa Correlate with Disease Severity and Promote the Release of Proinflammatory Cytokines in Macrophages

Neutralizing Anti‒DNase 1 and ‒DNase 1L3 Antibodies Impair Neutrophil Extracellular Traps Degradation in Hidradenitis Suppurativa

“…The decreased capability of HS serum samples to degrade NETs may contribute to immunogenicity and trigger aberrant innate and adaptive immune responses and autoantibody generation in this disease. In support of this, we previously confirmed the presence of autoantibodies against DNA, nuclear proteins, and NET components in HS patients(Carmona- Rivera et al, 2021).…”

“…As we previously reported the presence of autoantibodies in HS patients (Carmona-Rivera et al, 2021), we hypothesized that HS patients may develop antibodies against nucleases, similar to what has been described in other diseases such as SLE (Hartl et al, 2021). The most abundant and efficient nucleases present in circulation are DNase 1 and DNase 1L3 (Napirei et al, 2005).…”

“…Of particular interest, B cells and plasma cells are present in HS skin lesions and these cells display an activated immunophenotype in circulation (Byrd et al, 2019, Frew et al, 2020, Gudjonsson et al, 2020. Immunoglobulin G (IgG) levels are elevated in sera from HS patients and antibodies against extracellular matrix, nuclear and citrullinated J o u r n a l P r e -p r o o f antigens are also prevalent in this disease (Carmona-Rivera et al, 2021). We hypothesized that antibodies against DNases are present in HS patients and may contribute to the impaired NET degradation exhibited in this condition.…”

Disease Association of Anti‒Carboxyethyl Lysine Autoantibodies in Hidradenitis Suppurativa

“…Although autoantibodies have been previously identified in HS, for example anti-nuclear antibodies and anti-cyclic citrullinated peptide (Byrd et al, 2019, Carmona-Rivera et al, 2022, Mulani et al, 2018, they have all been associated more markedly with other autoimmune diseases (i.e. SLE and RA, respectively).…”

Pyoderma Gangrenosum: An Updated Literature Review on Established and Emerging Pharmacological Treatments

“…The role of B cells in PG, if any, remains unknown. A broad autoantibody response, also against neutrophil extracellular traps, has been documented in serum and skin from patients with hidradenitis suppurativa, associating with immune complex generation and macrophage activation [ 133 ]. Similar mechanisms may occur in PG [ 21 ].…”